ID A0A286XXD0_CAVPO Unreviewed; 3843 AA.
AC A0A286XXD0;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Bassoon presynaptic cytomatrix protein {ECO:0000313|Ensembl:ENSCPOP00000030130.1};
GN Name=BSN {ECO:0000313|Ensembl:ENSCPOP00000030130.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000030130.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000030130.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000030130.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Presynaptic active zone
CC {ECO:0000256|ARBA:ARBA00034101}.
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DR EMBL; AAKN02012901; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02012902; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02012903; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 10141.ENSCPOP00000030130; -.
DR Ensembl; ENSCPOT00000038876.1; ENSCPOP00000030130.1; ENSCPOG00000040726.1.
DR VEuPathDB; HostDB:ENSCPOG00000040726; -.
DR eggNOG; ENOG502QSYS; Eukaryota.
DR GeneTree; ENSGT00620000087961; -.
DR InParanoid; A0A286XXD0; -.
DR OMA; AHYYSDS; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000040726; Expressed in frontal cortex and 3 other cell types or tissues.
DR GO; GO:0030424; C:axon; IEA:Ensembl.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0098683; C:cochlear hair cell ribbon synapse; IEA:Ensembl.
DR GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR GO; GO:0098982; C:GABA-ergic synapse; IEA:Ensembl.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0044306; C:neuron projection terminus; IEA:Ensembl.
DR GO; GO:0014069; C:postsynaptic density; IEA:Ensembl.
DR GO; GO:0098831; C:presynaptic active zone cytoplasmic component; IEA:Ensembl.
DR GO; GO:0098685; C:Schaffer collateral - CA1 synapse; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0098882; F:structural constituent of presynaptic active zone; IEA:Ensembl.
DR GO; GO:0099526; P:presynapse to nucleus signaling pathway; IEA:Ensembl.
DR GO; GO:0035418; P:protein localization to synapse; IEA:Ensembl.
DR GO; GO:0098693; P:regulation of synaptic vesicle cycle; IEA:Ensembl.
DR GO; GO:0097091; P:synaptic vesicle clustering; IEA:Ensembl.
DR CDD; cd15773; FYVE1_BSN; 1.
DR CDD; cd15772; FYVE2_BSN_PCLO; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR030627; Bsn_FYVE_dom.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR008899; Znf_piccolo.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR14113; PICCOLO/BASSOON; 1.
DR PANTHER; PTHR14113:SF1; PROTEIN BASSOON; 1.
DR Pfam; PF05715; zf-piccolo; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 2.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 162..219
FT /note="Zinc finger piccolo-type"
FT /evidence="ECO:0000259|Pfam:PF05715"
FT DOMAIN 378..435
FT /note="Zinc finger piccolo-type"
FT /evidence="ECO:0000259|Pfam:PF05715"
FT REGION 1..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 224..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 284..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 439..846
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 861..1167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1187..1300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1316..1456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1489..1527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1834..1888
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2196..2280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2428..2571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2732..2776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3083..3136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3152..3285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3333..3470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3482..3818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2357..2387
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2853..2890
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 51..69
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 225..240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..512
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..551
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 590..630
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 693..711
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 712..740
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 872..900
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 901..926
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 927..945
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 972..1013
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1028..1042
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1068..1100
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1227..1255
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1279..1300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1316..1351
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1384..1456
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1489..1516
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1844..1864
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2263..2280
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2439..2453
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2460..2480
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2495..2525
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2556..2571
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2732..2768
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3083..3105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3112..3136
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3195..3221
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3368..3388
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3449..3470
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3485..3510
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3521..3549
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3563..3590
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3610..3625
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3659..3751
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3843 AA; 411385 MW; F4A865E19129E51C CRC64;
MGNEASLEGG AGDGPLSPGG AGPSSGRPPS APSGGGQLPA AAVATRATSG PPGPGPGPGP
GPGPGLGPRP DRLDPKEPSG SQRAASPTPK QASATAPSRE SSRETRPQGP AGQEADGPRR
TLQVDSRTQR SGRSPSVSPD RGSTPTSPYS VPQIAPLPSS TLCPICKTSD LTSTPSQPNF
NTCTQCHNKV CNQCGFNPNP HLTQVKEWLC LNCQMQRALG MDMTTAPRSK SQQQLHSPAL
SPAHSPAKQP LGKPEQEQSR GPGAPQLGSR QAETFRATSV LGPAQASALP EVEKVSPQPS
FPTKPSTAEH RPPVGETPAK SATTMPCGLG DTEQTQEGLT GKLFGLGASL LTQHGKVEHQ
AAPKTAAKPK TMPKEKATCP LCQAELNMGS KGPANYNTCT TCKLQVCNLC GFNPTPHLVE
KTDWLCLNCQ TKRLLEGSLG EQSPLPLPTS QQPPIGVPHR AAGSAPLKSK GTQGLGQPSG
PLPAKASPQP TKASPQPTKA SPLSTKASPQ AKPFKASESG KTPISAQERK TGVPAKAEPI
PKPPPETTLP PGTPKVKSGM KKIERASPAV KAVPEASKSG EAEEPMGKSY SQDLSRSPQS
LSDTGYSSDG ISSSQSEITG VVQQEVEQLD SAGVTGPCPP SPSELHKVGS SMQPLLEAQA
VAPSAEWSKL PCRITSEEQK QRPHSLSIMP EAFDSDEELE DILEEDEDSL EWGHQQEQRD
TAESSDDFGS QLRHDYVEDS SEGGLSPLPP QPPLRAAELT DEEFMRQQIL EMSAEEDNLE
EDDTAASGHG LAKHGTQKGS SGTRPRPESG QEPARRLPHN ATTGYEELLT EGGPTESTDS
GGGVLQGGLR RFKTIELNSS GSYSHELDLG QGPDASLDRE PELEMESLTG SPEDRSRGEH
SSTLPASTPS YTSGTSPTSL SSLEEDSDSS PSRRQRLEEA KQQRKARHRS HGPLLPTIED
SSEEEELREE EELLREQEKM REVEQQRIRS TARKTRRDKE ELRAQRRRER SKTPPSNLSP
IEDASPTEEL RQAAEMEELH RSSCSEYSPS PSLDSEAEAL DSGPSRLYKS GSEYNLPTFM
SLYSPTEMPL GSSTPPSSGR PLKSAEEAYE EMMRKAELLQ RQQSQVGGGH GPHGGPSQPT
DPRSQGSFEY QKAPDHDYGK TAQPVPEGTA ASLGTAVYQE ILQTSQSIAR MQQASSQDVA
FPEDKKPEKQ FLNADSAYMD PMKQNGGPLT PGTSPTQLAA PVSFTTSTSS DSSGGRVIPD
VRVTQHFAKE PQDPLKLHSS PAFPSSGSKE VGTSFSQGPG TPAITAVAPW YMTPTIPAAS
ESTPSLSSTT YSYGQSPSTA NYGSQTEELP KASSGPAAGS RAAREKALSR TDGEAGPPHV
SRGYSYFTGS SPPLSPSSPS ESPTFSTAKL GPRATVEFST QTPSPTPSLD MPWSPGTPTS
TSMVAQGTQT PHRPSTPHLV WQQTSHEAPF MVITLASDAS SQTGVVHASA STSPLCSPTD
SQPTPRSYSQ TMPPSVSQLP SEPPDFPRAP SAGVEGPLAL YSWGTLPAEN ISLCRISSVP
GTSRVEPGPR PPGSAVVDLR TAVKPTPIIL TDQGMDLTSL AVEARKYGLA LDPVPGRQST
AVQPLVINLN AQEQTHAFLG TATTVSITMA SSVLMAQQKQ PMVYGDPFQS RLDFGQGSGS
PVCLAQVKQV EQAVQTAPYR SGSRGRPREA KFARYNLPNQ VAPLARRDVL ITQMGTTQSI
SLKPGPVSEP SAEPHRAIPA ELRAHALPSA RKPHAVVVQM GEGTAGTVTT LLPEEPASAL
DLTGMRPESQ LACCDMVYKF PFGSSCTGTF HPTPSAPAKS MADTALPGQS SGPLYSSRDP
ETSEPPTYPQ GIVGPRPHEE QRPYPQGLPG RLYSSMSDTN LAEVGVNYQA HRLGHLFQGP
RRDSAMDLSS LKHSYSLGFA DGRYLGQGLQ YGSFTDLRHP TDLLIHPLPM RRYSSVSNIY
SDHRFGPRGE AGGFQEASLA QYSATTAREI SRMCAALNSM DQYGGRHASG GTGPDLVQYQ
PQHGPGLSAP QGLDPLRPGL LGNPTFPEGH PSPRNLAQYA PVASQGTAVR QLLPSTATVR
AADGMIYSTI NTPIAATLPI TTQPASVLRP MVRSGIYRPY VSGGATAVPL TSLTRVPMIA
PRVPLGPAGL YRYPAPSRFP ISSSVPPAEG PVYLGKPAAK APGSGPPARP ELPAGAAREE
PQSTAPPAVV KESVAAAASA PLPGQKPPGD GAAAGGGSVV LGRPGHEKEE ASQEERQRKQ
QEQLLQLERE RVELEKLRQM RLQEELERER VELQRHREEE QLLVQRELQE LQTIKHHVLQ
QQQEERQAQF ALQREQLAQQ RLQLEQIQQL QQQLQQQLEE QKQRQKAPFP VACEAPGRGP
PPAASELAQN GQYWPPLTHT AFLAVAGPEG PGQSREPMLH RSLPSSASDM SLQTEEPWEA
GRSGIKKRHS MPRLRDACEP ESAPEPCVVR RIADSSVQTD DEDGEGRYLL TRRRRTRRST
DCSVQTDDED NAEWEQPVRR RRSRLSRHSD SGSDSKHDAT ASSSTAASTA RAMSSVGIQT
ISDCSVQTEP DQLPRVSPAI HITAATDPKV EIVRYISAPE KTGHGESLAC QTEPDGQVQG
MAGPQLVGPT AISPYLPGIQ IVTPGPLGRF EKKKPDPLEI GYQAHLPLES LSQLVSRQPP
KSPQVLYSPV SPLSPHRLLD TSFASSERLN KAHVSPQKHF TTDSALRQQT LPRPMKTLQR
SLSDPKPLSP TAEESAKERF SLYQHQGGLG SQVSALPPNG LARKVKRTLP SPPPEEAHLP
LAGQAPPQLY AASLLQRGLV GPTTIPATKA SLLRELDRDL RLVEHESTKL RKKQAELDEE
EKEIDAKLKY LELGITQRKE SLAKDRGGRE CSPLRSLGAH RDYLSDSELN QLRLQGCTTP
AGQYSGFPAS AAAPATTSAP TAFQQPRFPP PAPQYTAGNI GPTQNELLAH QAPTYSGPSM
YPTPAFPPSS TYPTEPGLPN QQAFCPSGHY AAPTPMPTTQ STLMPIPADS RASQKPRQTS
LADLEQKVPT NYEVITTPVV AMSSAPSETS YSGPAVSSSY EQGKTPELPR ASDRGNVSQS
PVPTYPSDSH YTSLEQNVPR NYVMIDDISE LTKDSTVPDS QRLEPLGPGS SGRPGKEPGE
PGVLEGPTLP CCYTRGEEES EEDSYDSRGK AGHHHRSMES NGRPTSSHYY SDSDYRHGAR
VEKYGPGPVG PKHPSKSLAP AAVSSKRSKH RKQGMEQKIS KFSPIEEAKD VESDLASYPP
SAVSSNLASR GRKFQDEITY GLKKNVYEQQ RYYGVSSRDA AEEDERMYGG SSRSRIASAY
SGEKLSSHDF SGRGKGYERE REAVERLQKA GSKPSSLSMA HGRARPPMRS QASEEESPVS
PLGRPRPIGG TLPPGDTCAQ FCSSHSMPDV QEHVKDGPRA HSYKREEGYI LDDSHCVVSD
SEAYHLGQEE TDWFDKPRDA RSDRFRHHGG HAVSSSQKRG PARHSYHDYD EPPEEGLWSH
DEVGPGRHAP AKEHRHHSEH GRHTGRHAGE EPGRRTAKSH VRDSGRHEGR PHSQPSSAQA
MLKKGQPGYP SPTDYSQPSR APTAYHHTSD SKKGSRQAHS GPVVLQPKPE PQALPQGRQA
APGLQQSQPP PSRQMASGAA LRQPQMQQQQ QQQQQQQQQP GLGQQPPQQA LSQARPQQQS
QPAARGPASG ASQPTGKPQP GSMTATGSQP AGPPRAEQAD GSKVTTKPPQ QGRAPQAQPT
PGPGPAGMKA GARPGGPPGA APGQPGAEGE SVLSKILPGG AAEQAGKLTE AVSAFGKKFS
SFW
//
