ID A0A286XZB5_CAVPO Unreviewed; 1254 AA.
AC A0A286XZB5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCPOP00000030889.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000030889.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000030889.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000030889.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the vinculin/alpha-catenin family.
CC {ECO:0000256|ARBA:ARBA00008376}.
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DR EMBL; AAKN02046998; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02046999; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A286XZB5; -.
DR STRING; 10141.ENSCPOP00000030889; -.
DR Ensembl; ENSCPOT00000037661.1; ENSCPOP00000030889.1; ENSCPOG00000030726.1.
DR VEuPathDB; HostDB:ENSCPOG00000030726; -.
DR GeneTree; ENSGT01030000234543; -.
DR InParanoid; A0A286XZB5; -.
DR OMA; HEVCQKW; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR GO; GO:0005911; C:cell-cell junction; IEA:UniProt.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR Gene3D; 1.20.120.230; Alpha-catenin/vinculin-like; 2.
DR Gene3D; 1.20.120.810; Vinculin, Vh2 four-helix bundle; 2.
DR InterPro; IPR036723; Alpha-catenin/vinculin-like_sf.
DR InterPro; IPR006077; Vinculin/catenin.
DR PANTHER; PTHR18914; ALPHA CATENIN; 1.
DR PANTHER; PTHR18914:SF30; VINCULIN_ALPHA-CATENIN FAMILY MEMBER 1; 1.
DR Pfam; PF01044; Vinculin; 2.
DR SUPFAM; SSF47220; alpha-catenin/vinculin-like; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT REGION 180..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 350..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 42..76
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 350..364
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1254 AA; 138324 MW; 3AB1F779E1E7299B CRC64;
MESFLFDDIG CMIQNKAIER IISSMTVQLC HLLISVEMKD VNNKAFASLE KMAEELAEAS
EEFVQVAERL AEDAEEWFRE EMQLVAQSLI QSGRNIRVVA GKLHLQPGCQ YHWEELVTTA
QQILVDTTKV LLLEDAVTAR KVVQAAGWCT TRLDALEAAD GTTSLRGPWA DLAAAMLHLG
PPDGPGAARA PGPRRSPAAV LPAHPEPRRA PGAAGARRRG PGSWSVHPAP AAAAPAAGDA
GVRGAERRPD GRAPGGRGLA LPAPGRLLRA PERRHLVARC ARLLQLHGAG VRRPDGTYGP
LRIETGQQRL DPGKKCAALW AATEALSQGV RAGLLRRILD TFTDTSSPLR SLVHATQATP
PGRSSGDGEH SRRSLQLLLA AFQDQAKQML HVAQLVLVHC PGHQTGGNME AAMAHVWELV
VSIRQLFSQG YQGSGRDWSP AALQDLLGAW VWASERLLAC FDDVLDIPEF LRVSIQDMIK
HLDFFAWALK SAESREFSRS VAYLQGRATH IVQVMSRFVG QNRDPIFRNG LRVLIRQLEQ
SASVLGIAAE HGSSGYSSHD TDVFLTMAKN LIYSAQQVQE GLEGTNHPDI LSPLRHQVHR
FDIGRGWPYF ILSALQDPTS PELKYQKGPE LGEHEQGIPW PSMERLSHLW IPDIHAQRRD
LLALTTSKAI LSVESQGHQA VTSAGTNALQ QDLAAGAASE APAGEEPLGS KRTELQEVLM
LAPSDIDLTK ELSQRITDRR NRLPETTVQL PERTRKSKQA LVALAGDWYL LCQQLFCYNP
TIGLQRNIAV FMELQQNLAL MVQLAAKRPV YLDKKSPDST GYPEMLLQMQ GQLEKTEIHA
KQLLDQVLAS DGLQAPKSWE DNVEDGCLLW SVAVQDLIQS MERFSKRQSL FLLPLRQAVK
DQQGLQEGLA HIADVSQRLQ EAARLSGLLC GDEQVKGEVS FQCREVHVVR DALLDVAQIL
VSSPRPSPSL STRFDLLCLE LTLRAKALMD YLSTINADYE HTFHGAVCPR KESSLERMVS
GIQAVQGIIA RDQESESCQE DLLMALESIL ILTKEVAQRI PGFQEHPEEL GLYMLDCLRC
EWAAKAHHAV AQLQAWKGGH PKAWRFLAQC LKNAEEPVRI PEQDAIWIQL QCEEGTAGAS
AGARVDSNVR DSRVLTPYPL PAAEPQRPCA LAEQLYPEGR SADSENTITR IARETTGRRY
ELSTSVRKIA ASGQNFTRLV CIIAKNCVDQ RCSQELLYMV EQILTVSNQL HIIS
//
