ID A0A286XZP1_CAVPO Unreviewed; 2507 AA.
AC A0A286XZP1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Collagen type VI alpha 3 chain {ECO:0000313|Ensembl:ENSCPOP00000031028.1};
GN Name=COL6A3 {ECO:0000313|Ensembl:ENSCPOP00000031028.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000031028.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000031028.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000031028.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Collagen VI acts as a cell-binding protein.
CC {ECO:0000256|ARBA:ARBA00043858}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the type VI collagen family.
CC {ECO:0000256|ARBA:ARBA00044000}.
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DR EMBL; AAKN02019275; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 10141.ENSCPOP00000031028; -.
DR Ensembl; ENSCPOT00000031744.1; ENSCPOP00000031028.1; ENSCPOG00000011331.4.
DR VEuPathDB; HostDB:ENSCPOG00000011331; -.
DR GeneTree; ENSGT00940000156462; -.
DR InParanoid; A0A286XZP1; -.
DR OMA; KGGRQAN; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000011331; Expressed in uterine cervix and 12 other cell types or tissues.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0031012; C:extracellular matrix; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0042383; C:sarcolemma; IEA:Ensembl.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0043491; P:phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:0009411; P:response to UV; IEA:Ensembl.
DR CDD; cd00063; FN3; 1.
DR CDD; cd22629; Kunitz_collagen_alpha3_VI; 1.
DR CDD; cd01481; vWA_collagen_alpha3-VI-like; 3.
DR CDD; cd01450; vWFA_subfamily_ECM; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 4.10.410.10; Pancreatic trypsin inhibitor Kunitz domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 9.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR InterPro; IPR041900; vWA_collagen_alpha3-VI-like.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR22588:SF5; COLLAGEN ALPHA-6(VI) CHAIN; 1.
DR PANTHER; PTHR22588; UNCHARACTERIZED; 1.
DR Pfam; PF01391; Collagen; 2.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF00014; Kunitz_BPTI; 1.
DR Pfam; PF00092; VWA; 8.
DR PRINTS; PR00759; BASICPTASE.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00131; KU; 1.
DR SMART; SM00327; VWA; 9.
DR SUPFAM; SSF57362; BPTI-like; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF53300; vWA-like; 9.
DR PROSITE; PS00280; BPTI_KUNITZ_1; 1.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50234; VWFA; 9.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Collagen {ECO:0000256|ARBA:ARBA00023119};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 3..178
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 203..375
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 392..568
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 595..766
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 796..969
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 998..1171
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1197..1383
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1752..1931
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1969..2165
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 2320..2415
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2442..2492
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT REGION 1405..1718
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2507 AA; 270120 MW; F138758858383D22 CRC64;
KRDIVFLVDG SSKLGLANFN AIRDFIGKVI QRLEIGQDLI QVAVAQYADT VKPEFYFNTY
PSKREAINAV RRMKPMEGPA LNTGSALDFV RDNLFTSSVG SRAAEGIPKL LVLITGGKSL
DPVSQPAQEL KRSGILALAV GNKVADPAEL EEIAFDSSLV FIPNEFRAVP LQGVLPSLLS
PLRTLSGTTE GREVPLAQPG KRDILFLFDG SANLVGQFPA VRDFLYKIID ELDVKPDGIR
VAVAQYSDDV RLESRFNEHM TKPEILNLVK RMKIKTGKML NLGYALDFAQ RYIFVKTMGS
RIEDGVMQVL VLLVAGKSSD SVDVPARNLK QSGVIPFVFQ AKNADPAELE QIVLSPVFIL
AAESLPKIGE LQPQIVNLLK SAYDGGASGE KDVVFLIDGS EGVRSGFGLL KDFMERLVQS
LDVGPDRVRV AVVQYSDRTR PEFYLNSFMD QQGVISAIRR LSLLGGPTPN TGAALDFVLK
NILTRSAGSR MEDGVPQLLI VLTAERSGDD VRGPSAVLKR GGAVPIGIGI GNADISEMQT
ISFIPDFAVA IPNFRELGTV QQVVSERVIQ LSREELSRLQ PIFPAPTSPG GNKRDVVFLI
DGSQAASPEF QYIRGFIERL VDYLDVGFDT TRVAVIQFSG DPKVEFLLNA HSSKDEVQNA
VRRLRPKGGT QVNVGSALEY VSRNIFKRPL GSRIEEGVPQ FLVLISSGKS NDEVDDSAVE
LKQFGVAPFI VGRNADREEM VKISLSPEYV FSVSSFRELP SLEQRLLTPI TTLTAQQIRQ
ILASTTYPPP ESDAADIVFL IDSSDGVRSE GLVHIRDFVS RIVQRLSIGP SKVRIGLVQF
SNEVFPEFLL KTHRSQAAVL AAIRRLRFRG GAPLNVGKAL EYVAKNLFVK SAGSRIEDGV
PQHLVLLLGG KSQDDVSGFA RIITSSGIAS LGIGSRNVDQ TELQMITNDP RLVFTVREFK
DLPSIEERVI GSFGSSGITP APPAFTPFVS RPEKKKADIV FLLDGSINFR RDNFQEVLRF
VSEIVDTVYE EGDSIQVGLV QYNSDPTDEF FLKDFSSKRQ IIDAINKVVY KGGRHANTRV
GLQHLQLNHF IPEAGSRLDQ RVPQIAFVIT GGKSVEDAQD VSLALTQRGV KVFAVGVRNI
DSEEVGKIAS NSATAFRVGN VQELSELSEQ VLETLHDAMH ETLCPGVADV SKACNLDVIL
GFDGSRDQNV FAAQRGFESK VDTILSRISQ MQAISCSGSQ MPTVRVSVVA NGPSGPVEAF
NFDEYQPEQF EKFLSMRSQH PYVLTADTLK IYQNKFRQSS PDSVKVVIHF TDGADGDLAD
LHRASEALRE EGVHALILVG LERVVDLERL AHLEFGRGFL YDRPLRLNLL DLDYELAEQL
DNVAERACCG VPCKCSGERG DRGPIGSIGP KGISGEDGYR GYPGDEGGPG ERGPPGVNGT
QGFQGCPGQR GVKVHWTGGV DSEEGGELGE IGLDGLDGED VSGPPFSKPS ASGPKDSSGR
QLGPTGDKGA RGDVGIRGDP GDSGLDSQQK GPKGETGDIG PMGLPGRDGV SGSPGEPGKS
GGFGRRGPSG AKGNRGGPGQ AGFPGEQGTR GAQGPPGLIG PPGLSGEQGI PGPRGGGGIV
GAPGERGRAG PLGRKGEPGD PGPKGGLGNP GPRGETVRGQ VPRGSTERDG RERGFPGYPG
PKGTPGEPGA DGGPGPKGIR GRRGNSGPPG IVGQKGDPGY PGPSVSICPQ CALIQSIKDK
CRPLECPVFP TELAFALDTS EGVTQDIFSR MRDMVLSIVG NLTIAESNCP RGARVAVVTY
NNEVTTEIRF ADSRRKSALL DSIKNLQVAL TSKQQSLETA MSFVARNTFK RVRSGFLMRK
VAVFFSNRPT RATPQLREAV LKLSDAGITP LFLTSQEDRP LVNALQINNT AVGHVLVLPA
RNDLSNFLKN VLTCHVCLDI CNIDPSCGFG SWRPSFRDRR AAGSNSDIDL AFILDSSETT
SLFQFNEMKK YIGYVVRQLD LSPDPGVSQH LARVAVVQHA PSATLGNASA PPARVELSLT
DYGSKEKLLA FLGRGVRQLQ GTRALGSTIE YTIQNVFEST TNPRDLKVLV LMLTGEVRGE
ELEVAQRAIL WAKCKGYFFV VLGIGRKVNV KETYGFASEP NDVFFKLVDD STELNEEPLL
RFGRLLPSFV GSENAFYLSP DIKKQCDWFQ EDQPAKNGVK FGHKQVNVPN NVTLSVTTKP
MTITKPVTTT TKSATIVNLP SAKPAPANPA ASKPVAVNPA AMKPPVAVSP GAEKPVAANP
GAEKPIAMNP GAAKSVAANP PVLKPVAGNP AAAKPISAQP PVPEVQVSEV TEHSARLRWE
RPEPPSSYFY DLTVTSAHDQ SLVLRQNLTV TERVLSGLRA GQTYYVVVVC YLRSQVRAVF
RGTFSTKKSQ PPPPPPARPA SSASINLVVK TEPLAFTGTD ICKLPRDDGT CRDFVLRWYY
DTKTESCARF WYGGCGGNEN RFDSQQNCEK LCASALPKPG VINVMGT
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