ID A0A286Y133_CAVPO Unreviewed; 1152 AA.
AC A0A286Y133;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=BAI1 associated protein 3 {ECO:0000313|Ensembl:ENSCPOP00000031536.1};
GN Name=BAIAP3 {ECO:0000313|Ensembl:ENSCPOP00000031536.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000031536.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000031536.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000031536.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the unc-13 family.
CC {ECO:0000256|ARBA:ARBA00005823}.
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DR EMBL; AAKN02007396; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003478487.1; XM_003478439.3.
DR AlphaFoldDB; A0A286Y133; -.
DR STRING; 10141.ENSCPOP00000031536; -.
DR Ensembl; ENSCPOT00000043266.1; ENSCPOP00000031536.1; ENSCPOG00000010436.4.
DR GeneID; 100722487; -.
DR KEGG; cpoc:100722487; -.
DR CTD; 8938; -.
DR VEuPathDB; HostDB:ENSCPOG00000010436; -.
DR eggNOG; KOG1328; Eukaryota.
DR GeneTree; ENSGT00730000110939; -.
DR InParanoid; A0A286Y133; -.
DR OMA; WLAEAMN; -.
DR OrthoDB; 3059697at2759; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000010436; Expressed in pituitary gland and 3 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0098982; C:GABA-ergic synapse; IEA:Ensembl.
DR GO; GO:0031902; C:late endosome membrane; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0098793; C:presynapse; IEA:GOC.
DR GO; GO:0055038; C:recycling endosome membrane; IEA:Ensembl.
DR GO; GO:0032588; C:trans-Golgi network membrane; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
DR GO; GO:0005543; F:phospholipid binding; IEA:Ensembl.
DR GO; GO:0019905; F:syntaxin binding; IEA:Ensembl.
DR GO; GO:1990502; P:dense core granule maturation; IEA:Ensembl.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0035774; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Ensembl.
DR GO; GO:0001956; P:positive regulation of neurotransmitter secretion; IEA:Ensembl.
DR GO; GO:0050795; P:regulation of behavior; IEA:Ensembl.
DR GO; GO:1905413; P:regulation of dense core granule exocytosis; IEA:Ensembl.
DR GO; GO:0032228; P:regulation of synaptic transmission, GABAergic; IEA:Ensembl.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:Ensembl.
DR CDD; cd08676; C2A_Munc13-like; 1.
DR CDD; cd04009; C2B_Munc13-like; 1.
DR Gene3D; 1.10.357.50; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR010439; MUN_dom.
DR InterPro; IPR014770; Munc13_1.
DR InterPro; IPR014772; Munc13_dom-2.
DR PANTHER; PTHR45999:SF1; BAI1-ASSOCIATED PROTEIN 3; 1.
DR PANTHER; PTHR45999; UNC-13-4A, ISOFORM B; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF06292; MUN; 1.
DR SMART; SM00239; C2; 2.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS51258; MHD1; 1.
DR PROSITE; PS51259; MHD2; 1.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 141..300
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 628..749
FT /note="MHD1"
FT /evidence="ECO:0000259|PROSITE:PS51258"
FT DOMAIN 853..961
FT /note="MHD2"
FT /evidence="ECO:0000259|PROSITE:PS51259"
FT DOMAIN 975..1101
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 20..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 195..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1152 AA; 129561 MW; E6858166B357B61F CRC64;
MSTLLEIKSS VLRQVQVCPS FRRKTEPEPG STSADSQEPT TGIWKPEDGM EFFAHMRLIL
KKEEGRQGLP CPEVLLRSGS PAPAEPVDPN RGLRALTQEE VEMLYEEALY TVLHRAGTMG
PDQVEDEEIL LGYLQQVFGT SPEEHTEAIE RVKKAKAPTY TLKVSVMRAK NLLAKDPNGF
SDPYCMLSIL PASATPQEQS GQKEQRFSFR KSSKHSSPLP AKCIRVTEVK SSTLNPVWKE
HFLFEIEDVN TDQLHLDIWD HDDDVSLAEA CRKLNEVIGF KGMSRYFKQI VKSARANGTA
GPTEDHTDDF LGCLNIPVRE VPVAGADRWF KLEPRSSASR VQGDCHLVLK LITTQRDTVM
SHRGRSGFQS YLLLLSRILQ FEHHAQESSS RSWHGEFSRP GSTILCLHGA QSNLSPLQLA
ILHWQVSSHH HQTCTLDYSY LLGLLEDMQA HWEEAASLPQ DQEESLADSF SAFSEYGLQL
LHQLRDYFPA TNSTAIYRLE LLLKCLDKLQ LFQPSFEICP FETELNVDVT AALKRGNREW
YNRLLNSKSP REQSGPQRLP GLVELADIIY EDLQACYGIY ASLFHGILKV DFFTLTFRQL
ERLLAEEAWV LTEELSPKMT VQVASGLLEL YLTLADTQRF WSCIPGRDGR SLALAGIHTP
FLPAVKIWLQ MLRDQVKWRL QGAVDVDTLE PVDASSKHSS SAATASLCFS HIQELWVHLA
WPDPAQAQGL GTQLSQDMCG AALFYTELLR KKVDTQPRAV DEAVSEPLCV VLNNVELVRR
ASGQALRGLA WPEGIGGVET TLPRALLSCT QALEEDLEHE AHTVTAHLTS KMVADIRKYM
QHISLSPDSI QNDEAIAPLM KYLDEKLALL NASLVKENLS RVLEALWELL LQAILQALGG
NSDVSADFYG RFHFTLEALV SFFHAEGQGL PLESLKDGSY KRLEEELRLH KCSTRECIEQ
FYLDKLKQRS LEQNRFGRLS VRCYYEAAEQ RLAVEVLHAA DLLPLDTNGL SDPFVIVELG
PPHLFPLVRS QRTQVKARTL HPVYDELFHF SVSAEACRRR GACVLFTVMD HDWLSTNDFA
GEAALGLSGV SGILRPQVGG GMRAGQPIIL HLRRPRAQVR SALRMLEGRT NKEAQEFVKK
LKELEKYMEA DP
//
