ID A0A286Y1E0_CAVPO Unreviewed; 901 AA.
AC A0A286Y1E0;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Exosome component 10 {ECO:0000313|Ensembl:ENSCPOP00000031644.1};
GN Name=EXOSC10 {ECO:0000313|Ensembl:ENSCPOP00000031644.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000031644.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000031644.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000031644.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the exosome component 10/RRP6 family.
CC {ECO:0000256|ARBA:ARBA00043957}.
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DR EMBL; AAKN02028879; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A286Y1E0; -.
DR STRING; 10141.ENSCPOP00000031644; -.
DR Ensembl; ENSCPOT00000036370.1; ENSCPOP00000031644.1; ENSCPOG00000011628.4.
DR VEuPathDB; HostDB:ENSCPOG00000011628; -.
DR eggNOG; KOG2206; Eukaryota.
DR GeneTree; ENSGT00390000015408; -.
DR InParanoid; A0A286Y1E0; -.
DR OMA; NIMRPQM; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000011628; Expressed in testis and 13 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0000791; C:euchromatin; IEA:Ensembl.
DR GO; GO:0000176; C:nuclear exosome (RNase complex); IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0032040; C:small-subunit processome; IEA:Ensembl.
DR GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IEA:Ensembl.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0071034; P:CUT catabolic process; IEA:Ensembl.
DR GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:InterPro.
DR GO; GO:0071044; P:histone mRNA catabolic process; IEA:Ensembl.
DR GO; GO:0032211; P:negative regulation of telomere maintenance via telomerase; IEA:Ensembl.
DR GO; GO:0071028; P:nuclear mRNA surveillance; IEA:Ensembl.
DR GO; GO:0071035; P:nuclear polyadenylation-dependent rRNA catabolic process; IEA:Ensembl.
DR GO; GO:1905746; P:positive regulation of mRNA cis splicing, via spliceosome; IEA:Ensembl.
DR GO; GO:1904872; P:regulation of telomerase RNA localization to Cajal body; IEA:Ensembl.
DR GO; GO:0042274; P:ribosomal small subunit biogenesis; IEA:Ensembl.
DR CDD; cd06147; Rrp6p_like_exo; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR012588; Exosome-assoc_fac_Rrp6_N.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR045092; Rrp6-like.
DR InterPro; IPR049559; Rrp6p-like_exo.
DR PANTHER; PTHR12124:SF47; EXOSOME COMPONENT 10; 1.
DR PANTHER; PTHR12124; POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF08066; PMC2NT; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SMART; SM00341; HRDC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Exosome {ECO:0000256|ARBA:ARBA00022835};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552}.
FT DOMAIN 519..599
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 229..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 794..901
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..248
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 794..826
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 901 AA; 102685 MW; 3132FD4F506475F7 CRC64;
MRDPQTLARR AARAGKMAAP SPQELKSQAV PSATKPDGEM VLPGFPDADS FVKFALGSVV
AVTKASGGLP QFGDEYDFYR SFPGFQAFCE TQGDRLLQCM SRVMQYHGCR SNIKDRSKVT
ELEDKFDLLV DTNDVILERV GILLDEAAGL NKHQQPVLPA GLQVPKTIVS SWNRKAGEYG
KKAKSETFRL LHAKNIIRPQ LKFREKIDNS NTPFLPKIFI KPNAQKPLPQ VLSKERRERP
QDRPEDLDVP PALADFIHQQ RTQQIEQDMF AHPYQYELDH FTPSESVLQK PQPQLYRPVE
ETPCHFVSSL DELVELNEKL LRCEEFAVDL EHHSYRSFLG LTCLMQISTR TEDFLVDTLE
LRSEMYILNE SLTNPAIVKV FHGADSDIEW LQKDFGLYVV NMFDTHQAAR LLNLGRHSLD
HLLRLYCGVE SNKQYQLADW RVRPLPEEML SYARDDTHYL LYIYDKMRLD LWERGNEQPV
QLQVVWQRSR DICLKKFVKP IFTDESYLEL YRKQKKHLNS QQLTAFQLLF AWRDKTARRE
DESYGYVLPN HMMLKIAEEL PKEPQGIIAC CNPVPPLVRQ QINEMHLLIQ QAREMPLLKS
ETAAGVKKSG PLPDIERLEN VLFGPHDCSH APPDSYPVTP TAGPVPAWKQ ASLFADPREE
TLLDTQCLLA TAVITVFDEP SAEENGNTPL TAAQKRARNI MESFENPFRM FLPSLEHRAH
ISQAAKFDPS SKIYEISNRW KLASQVQVQK EAKETAKKKA AEQTAAREQA KEEYKATAGQ
AISVRQQAVL ENAAKKRERT TSDPRATEQK QEKRLKTARK PKAPAPPEKE FTPYDYSQSD
FKAFTGDGKS RPSSQFDPNK QTAAGKKCAA AKKPKQSAGA KSVSFPTGKS DRGFRHNWPK
R
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