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Database: UniProt
Entry: A0A286Y206_CAVPO
LinkDB: A0A286Y206_CAVPO
Original site: A0A286Y206_CAVPO 
ID   A0A286Y206_CAVPO        Unreviewed;      1640 AA.
AC   A0A286Y206;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   05-JUN-2019, entry version 13.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCPOP00000031861};
GN   Name=Rapgef2 {ECO:0000313|Ensembl:ENSCPOP00000031861};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Caviidae; Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000031861, ECO:0000313|Proteomes:UP000005447};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000031861, ECO:0000313|Proteomes:UP000005447}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000031861,
RC   ECO:0000313|Proteomes:UP000005447};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000031861}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000031861};
RG   Ensembl;
RL   Submitted (OCT-2017) to UniProtKB.
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DR   EMBL; AAKN02012077; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02012078; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02012079; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02012080; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSCPOT00000036101; ENSCPOP00000031861; ENSCPOG00000031894.
DR   GeneTree; ENSGT00940000156418; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0017034; F:Rap guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0042127; P:regulation of cell population proliferation; IEA:InterPro.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 2.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 2.60.120.10; -; 2.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR030739; RapGEF2.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23113; PTHR23113; 1.
DR   PANTHER; PTHR23113:SF217; PTHR23113:SF217; 1.
DR   Pfam; PF00595; PDZ; 1.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00100; cNMP; 2.
DR   SMART; SM00228; PDZ; 1.
DR   SMART; SM00314; RA; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF48366; SSF48366; 1.
DR   SUPFAM; SSF50156; SSF50156; 1.
DR   SUPFAM; SSF51206; SSF51206; 2.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 2.
DR   PROSITE; PS50106; PDZ; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-
KW   ProRule:PRU00168, ECO:0000256|SAAS:SAAS01081641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT   DOMAIN        3     50       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
FT   DOMAIN      262    362       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
FT   DOMAIN      394    507       N-terminal Ras-GEF. {ECO:0000259|PROSITE:
FT                                PS50212}.
FT   DOMAIN      512    582       PDZ. {ECO:0000259|PROSITE:PS50106}.
FT   DOMAIN      733    819       Ras-associating. {ECO:0000259|PROSITE:
FT                                PS50200}.
FT   DOMAIN      844   1071       Ras-GEF. {ECO:0000259|PROSITE:PS50009}.
FT   REGION      165    228       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A286Y206}.
FT   REGION     1129   1175       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A286Y206}.
FT   REGION     1218   1279       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A286Y206}.
FT   REGION     1349   1383       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A286Y206}.
FT   REGION     1428   1640       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A286Y206}.
FT   COILED      355    375       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS    165    192       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A286Y206}.
FT   COMPBIAS    208    223       Acidic. {ECO:0000256|MobiDB-lite:
FT                                A0A286Y206}.
FT   COMPBIAS   1231   1279       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A286Y206}.
FT   COMPBIAS   1369   1383       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A286Y206}.
FT   COMPBIAS   1429   1453       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A286Y206}.
FT   COMPBIAS   1464   1478       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                A0A286Y206}.
SQ   SEQUENCE   1640 AA;  183058 MW;  25E35786CE4613AB CRC64;
     MEALSNLREH QLRLMCETVR YERHEANEVL YYPDDIGTCW YILLSGSVFI KESMFLPRSS
     FGKRSAGSFR RGCECIVLEP SEMIVVDYMD ENEEYFQRQA SHRQSRRRFR KINQKGERQT
     IIDTVDPYPM GKPPLPRGYH TECTKSQLPA DFTKLHLTDS LHPQVTHVSS SHSGCSITSD
     SGSSSLSDIY QATESEAGDM DLSGLPETAV DSEDDDDEED IERASDPLMS RDVVRDCLEK
     DPIDRTDDDI EQLLEFMHQL PAFANMTMSV RRELCAVMVF AVVERAGTIV LNDGEELDSW
     SVILNGSVEV TYPDGKAEIL CMGNSFGVSP TMDKEYMKGV MRTKVDDCQF VCIAQQDYCR
     ILNQVEKNMQ KVEEEGEIVM VKEHRELDRT GTRKGHIVIK GTSERLTMHL VEEHSVVDPT
     FIEDFLLTYR TFLSSPMEVG KKLLEWFNDP TLRDKVTRVV LLWVNNHFND FEGDPAMTRF
     LEEFENNLER EKMGGHLRLL NIACAAKAKR RLMTLTKPCR EAPLPFLLLG GSEKGFGIFV
     DSVDPGSKAA EAGLKRGDQI LEVNGQNFEN IQLSKAMEIL RNNTHLSITV KTNLFVFKEL
     LTRLSEEKRN GAPHLPKIGD IKKASRYSIP DLAVDVEQVI GLEKVNKKSK ANTVGGRNKL
     KKILDKTRIS ILPQKPYNDI GIGQSQDDSI VGLRQTKHIP AALPVSGTLS SSNPDLLQSH
     HRILDFSATP DLPDQVLRVF KADQQSRYIM ISKDTTAKEV VIQAIREFAI TATPDQYSLC
     EVSVTPEGVI KQRRLPDQLS KLADRIQLSG RYYLKNNMET ETLCSDEDAQ ELLRESQISL
     LQLSTVEVST QLSMRNFELF RNIEPTEYID DLFKLRSKTS CANLKMFEEV INQETFWVAS
     EILRETNQLK RMKIIKHFIK IALHCRECKN FNSMFAIISG LNLAPVARLR TTWEKLPNKY
     EKLFQDLQDL FDPSRNMAKY RNVLNSQNLQ PPIIPLFPVI KKDLTFLHEG NDSKVDGLVN
     FEKLRMIAKE IRHVGRMASV NMDPALMFRT RKKKWRSLGS LSQGSANAAV LDVAQTGGHK
     KRVRRSSFLN AKKLYEDAQM ARKVKQYLSN LELEMDEESL QTLSLQCEPA SSTLPKNPGD
     KKPVKSETSP VAPRAGTQQK AQLQPPPQPQ PVQKLGQGLQ VPAVSLYPSR KKVPVKDLPP
     FGINSPQALK KILSLSEEGS LERHRKQAED TLSSASSQLS SPPTSPQSSP RKGYTLAPSG
     TVDNFSDSGH SEISSRSSIV SNSSFDSVPV ALHEERRQRH SVSLVESGLG VGRAERRTVL
     EPDQYSLGSY AATAEARGMF ATATVLTSPS AEELSQDQGD RASLDAADSG RGSWTSCSSG
     SHDNIQTIQH QRSWETLPFG HAPCDYPGDP TGLWAAGGHL DHTMFAEHGQ KGSRQNPSRE
     SLEQAQSRAS WASPTGYWGE DAEGDTGTIK RRGGKDVSLE AESGSSLAPA PTEEPKAGTV
     PAHGAATSSA AKGLVARKEG RYREPPPTPP GYVGIPISDF EAPPHPARRP PDYTVALQRS
     RMVARPAEVS SSAPGSRQGS RPQWHKLGEA DPRLAPYQAQ GFSTEEDGRC GRRRWGSAGP
     GWARMGRFHL VGKLPEQGRP
//
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