ID A0A286Y248_CAVPO Unreviewed; 724 AA.
AC A0A286Y248;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=GRB2 associated binding protein 1 {ECO:0000313|Ensembl:ENSCPOP00000031615.1};
GN Name=GAB1 {ECO:0000313|Ensembl:ENSCPOP00000031615.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000031615.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000031615.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000031615.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GAB family. {ECO:0000256|ARBA:ARBA00029462}.
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DR EMBL; AAKN02011859; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02011860; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003476897.1; XM_003476849.3.
DR AlphaFoldDB; A0A286Y248; -.
DR Ensembl; ENSCPOT00000031485.1; ENSCPOP00000031615.1; ENSCPOG00000031770.1.
DR GeneID; 100730023; -.
DR CTD; 2549; -.
DR VEuPathDB; HostDB:ENSCPOG00000031770; -.
DR GeneTree; ENSGT00940000156801; -.
DR OrthoDB; 2904117at2759; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000031770; Expressed in heart left ventricle and 12 other cell types or tissues.
DR CDD; cd01266; PH_Gab1_Gab2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR046355; Gab1-4-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR45960; GRB2-ASSOCIATED-BINDING PROTEIN; 1.
DR PANTHER; PTHR45960:SF5; GRB2-ASSOCIATED-BINDING PROTEIN 1; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 5..116
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 194..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 320..363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 491..686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 701..724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..230
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 519..564
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 598..643
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 652..668
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 724 AA; 80047 MW; 719E95AA2D7D6D48 CRC64;
MSGGEVVCSG WLRKSPPEKK LKRYAWKRRW FVLRSGRLTG DPDVLEYYKN DHAKKPIRII
DLNLCQQVDA GLTFNKKEFE NSYIFDINTI DRIFYLVADS EEEMNKWVRC ICDICGFNPT
EEDPVKPPST SLQAPADPAF AINVAASCTQ AEPTSAALPL PYQLISLPPH PEPLGIQDDP
QDYLLLINCQ SKKPEPTRTH ADSAKSTSSE TDCNDNVPPH KNPASSQSKH GVNGFFQQQV
MYDSLPSRAT SVSVDSSLYK LPRSYSHDVL PKESPSSTEA DGELYVFNTP SGTSSVETQM
RHISVSYDIP PTPGNTYQIP RTFPEGTLGQ TSKLDALPDI PPPRPPKPHP THDRSPVETC
SIPHGALDTD SSYCIPTAGM PPSRSNTIST VDLNKLRKDA GSQDCYDIPR TFPSDRSSSL
EGFHNHFKIK NVLTVGSVSS EELDENYVPM NPNSPPRQHS SSFTEPIQEA NYVPMTPGTF
DFSSFGMQVP PPAHMGFRSS PKTPPRRPVP VADCEPPPVD RNLKPDRKGQ SPKILRPKPH
GLERTDSQTI GDFPTRRKAK PAPLEIKPLP EWEELQAPVR SPITRSFARD SSRFPISPRP
DSVHSTTSSS DSHDSEENYV PMNPNLSSEE PNLFGSNSLD GGSSPMIKPK GDKQVEYLDL
DLDSGKSTPP RKQKSSGSGS SVADERVDYV VVDQQKTLAL KSTREAWTDG RQSTESETPT
KSVK
//
