ID A0A286Y2V3_CAVPO Unreviewed; 657 AA.
AC A0A286Y2V3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Mitogen-activated protein kinase kinase kinase 3 {ECO:0000313|Ensembl:ENSCPOP00000031840.1};
GN Name=MAP3K3 {ECO:0000313|Ensembl:ENSCPOP00000031840.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000031840.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000031840.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000031840.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02045207; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005002027.1; XM_005001970.2.
DR AlphaFoldDB; A0A286Y2V3; -.
DR STRING; 10141.ENSCPOP00000031840; -.
DR Ensembl; ENSCPOT00000037135.1; ENSCPOP00000031840.1; ENSCPOG00000022367.2.
DR GeneID; 100731994; -.
DR KEGG; cpoc:100731994; -.
DR CTD; 4215; -.
DR VEuPathDB; HostDB:ENSCPOG00000022367; -.
DR GeneTree; ENSGT00940000158767; -.
DR InParanoid; A0A286Y2V3; -.
DR OMA; ITTSPCA; -.
DR OrthoDB; 145974at2759; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000022367; Expressed in uterine cervix and 13 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0001568; P:blood vessel development; IEA:Ensembl.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:Ensembl.
DR GO; GO:2000773; P:negative regulation of cellular senescence; IEA:Ensembl.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0090050; P:positive regulation of cell migration involved in sprouting angiogenesis; IEA:Ensembl.
DR GO; GO:0071864; P:positive regulation of cell proliferation in bone marrow; IEA:Ensembl.
DR GO; GO:1900745; P:positive regulation of p38MAPK cascade; IEA:Ensembl.
DR CDD; cd06405; PB1_Mekk2_3; 1.
DR CDD; cd06625; STKc_MEKK3_like; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000270; PB1_dom.
DR InterPro; IPR034879; PB1_MEKK2/3.
DR InterPro; IPR000719; Prot_kinase_dom.
DR PANTHER; PTHR48016; MAP KINASE KINASE KINASE SSK2-RELATED-RELATED; 1.
DR PANTHER; PTHR48016:SF50; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19; 1.
DR Pfam; PF00564; PB1; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00666; PB1; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF54277; CAD & PB1 domains; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51745; PB1; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Transferase {ECO:0000256|ARBA:ARBA00022777}.
FT DOMAIN 75..154
FT /note="PB1"
FT /evidence="ECO:0000259|PROSITE:PS51745"
FT DOMAIN 393..653
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 22..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 155..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 249..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..42
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 249..284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 657 AA; 73966 MW; 6875A78C481E52E3 CRC64;
MDEQEALDSI MKDLVALQMS RRPRVSGYET MKNKDTSHPN RQKKHSSSSS ALLNSPTITT
SSCAGASEKK KFLSDVRIKF EHNGERRIIA FSRPVRYEDV ELKVAKVFGQ PLDLHYMNNE
LSILLKNQDD LDKAIDILDR SSSMKSLRIL LLSQDRNDTS SSPHSGVSKQ VRIKASQSAG
DINTIYQPPE PRSRHLSVSS QNPGRSSPPP GYVPERQQHI ARQGSYTSIN SEGEFIPETS
EQCMLDPLSS AENSLSGSCQ SLDRSADSPS FRKSRMSRAQ SFPDNRQEYS DRETQLYDKG
VKGGTYPRRY HVSVHHKDYN DGRRTFPRIR RHQGNLFTLV PSSRSLSTNG ENMGLAVQYL
DPRGRLRSAD SENTLSVQER NVPTKSPSAP INWRRGKLLG QGAFGRVYLC YDVDTGRELA
SKQVQFDPDS PETSKEVSAL ECEIQLLKNL QHERIVQYYG CLRDRAEKTL TIFMEYMPGG
SVKDQLKAYG ALTESVTRKY TRQILEGMSY LHSNMIVHRD IKGANILRDS AGNVKLGDFG
ASKRLQTICM SGTGMRSVTG TPYWMSPEVI SGEGYGRKAD VWSLGCTVVE MLTEKPPWAE
YEAMAAIFKI ATQPTNPQLP SHISEHGRDF LRRIFVEAHQ RPSAEELLTH HFAQLVY
//
