ID A0A286Y3A2_CAVPO Unreviewed; 453 AA.
AC A0A286Y3A2;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Keratin 35 {ECO:0000313|Ensembl:ENSCPOP00000032032.1};
GN Name=KRT35 {ECO:0000313|Ensembl:ENSCPOP00000032032.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000032032.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000032032.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000032032.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR EMBL; AAKN02042410; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003467017.1; XM_003466969.2.
DR AlphaFoldDB; A0A286Y3A2; -.
DR STRING; 10141.ENSCPOP00000032032; -.
DR Ensembl; ENSCPOT00000033398.1; ENSCPOP00000032032.1; ENSCPOG00000030708.1.
DR GeneID; 100712730; -.
DR KEGG; cpoc:100712730; -.
DR CTD; 3886; -.
DR VEuPathDB; HostDB:ENSCPOG00000030708; -.
DR GeneTree; ENSGT00940000161787; -.
DR InParanoid; A0A286Y3A2; -.
DR OMA; SYRVASC; -.
DR OrthoDB; 4640531at2759; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000030708; Expressed in zone of skin and 2 other cell types or tissues.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; INTERMEDIATE FILAMENT; 1.
DR PANTHER; PTHR23239:SF193; KERATIN, TYPE I CUTICULAR HA5; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR SUPFAM; SSF46579; Prefoldin; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 95..406
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 99..169
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 205..324
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 357..391
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 453 AA; 50521 MW; 6528D5CE00D65CD6 CRC64;
MASKCHKASF SSGSLKSPAG AASGSTRVAT MYSSSSCKLS HGPRSFSVCP AGLGRSSYGA
ASCLPGPYFP TGSFATSYSV AGGSWFGEGE LTGSEKETMQ FLNERLASYL EKVRQLEREN
AELEGRIRDW CEQQVPYMRP DYQSYFQAIE ELQKKILSNK AENARLVVQI DNAKLAADDF
RTKYETELSL RQLVESDING LRRILDDLTL CKSDLEAQVE SLKEELLCLK KNHEEEVNSL
RCQLGDRLNV EVDAAPPVDL NRVLNEMRCQ YETLVENNRR EAEDWFDTQT EELNKQVVSS
SEQLQSYQAE IIELRRTVNA LEIELQAQHS TRDALESSLM ETESRYSAQL AQVQHLIINV
ESQLAEIRGD LERQNEEYQV LLDVRARLEG EINTYRGLLE SEDSKLPCNP CAADLSPSKS
CLPCLPAASC SSVTARTTGS PRPVYVPCSG GRF
//
