ID A0A286Y3T5_CAVPO Unreviewed; 129 AA.
AC A0A286Y3T5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=TNF receptor superfamily member 12A {ECO:0000313|Ensembl:ENSCPOP00000032502.1};
GN Name=TNFRSF12A {ECO:0000313|Ensembl:ENSCPOP00000032502.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000032502.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000032502.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000032502.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02007412; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003477744.1; XM_003477696.2.
DR AlphaFoldDB; A0A286Y3T5; -.
DR STRING; 10141.ENSCPOP00000032502; -.
DR Ensembl; ENSCPOT00000034068.1; ENSCPOP00000032502.1; ENSCPOG00000008467.4.
DR GeneID; 100735594; -.
DR KEGG; cpoc:100735594; -.
DR CTD; 51330; -.
DR VEuPathDB; HostDB:ENSCPOG00000008467; -.
DR eggNOG; ENOG502SFZC; Eukaryota.
DR GeneTree; ENSGT00390000001948; -.
DR InParanoid; A0A286Y3T5; -.
DR OMA; HSDFCRG; -.
DR OrthoDB; 4612315at2759; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000008467; Expressed in thyroid gland and 12 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0061041; P:regulation of wound healing; IEA:Ensembl.
DR CDD; cd13413; TNFRSF12A; 1.
DR Gene3D; 4.10.400.20; -; 1.
DR InterPro; IPR022316; TNFR_12.
DR PANTHER; PTHR32037; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 12A; 1.
DR PANTHER; PTHR32037:SF2; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 12A; 1.
DR Pfam; PF12191; stn_TNFRSF12A; 1.
DR PRINTS; PR01962; TNFACTORR12.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..129
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011717607"
FT TRANSMEM 78..101
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 129 AA; 13820 MW; CB22E8BF6557F2D1 CRC64;
MAVGWLRWLL RLLVLGLMLA LPRAAAGEQA PGTAPCSRGS SWSADLDKCM DCASCPTRPH
SDFCRGCAAT PPAPFQLLWP ILGGALSLAL VLALLSGFLV WRRCRRREKF TTPIEETGGE
GCPGVALIQ
//
