ID A0A286Y3V1_CAVPO Unreviewed; 733 AA.
AC A0A286Y3V1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=RAP1 GTPase activating protein 2 {ECO:0000313|Ensembl:ENSCPOP00000032384.1};
GN Name=RAP1GAP2 {ECO:0000313|Ensembl:ENSCPOP00000032384.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000032384.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000032384.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000032384.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02033256; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02033257; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_013007651.1; XM_013152197.1.
DR AlphaFoldDB; A0A286Y3V1; -.
DR Ensembl; ENSCPOT00000036143.1; ENSCPOP00000032384.1; ENSCPOG00000000079.4.
DR VEuPathDB; HostDB:ENSCPOG00000000079; -.
DR GeneTree; ENSGT00940000160935; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000000079; Expressed in frontal cortex and 11 other cell types or tissues.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15711:SF17; RAP1 GTPASE-ACTIVATING PROTEIN 2; 1.
DR Pfam; PF21022; Rap-GAP_dimer; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW ProRule:PRU00165}; Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 250..466
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 23..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 556..733
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 577..618
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 634..652
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 661..691
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 733 AA; 80783 MW; 44298AF8315508ED CRC64;
MHLPKAGIRA AVVLIGLLHK SRKQNKEKRK QELANSSDVT LPDQPLSPPL TAPPTMKSAE
FFEMLEKMQG IKLEEQRPGP QKNKDDYIPY PSIDEVVEKG GPYPLIILPQ FGGYWIEDPE
NVGTPTSLGS SICEEEEEDG LSPNTFGYKL ECKGEARAYR RHFLGKDHLN FYCTGSSLGN
LILSIKCEEV EGIEYLRIIL RSKLKTVHER IPLAGLSKLP SVPQIAKAFC DDAVGLKFNP
VLYPKASQMI VSYDEHDVNN TFKFGVIYQK ARQTLEEELF WNNEESPAFK EFLDLLGDTI
TLQDFKGFRG GLDVTHGQTG VESVYTTFRD REIMFHVSTK LPFTEGDAQQ LQRKRHIGND
IVAIIFQEEN TPFVPDMIAS NFLHAYIVVQ VESPGTEIPS YKVSVTARED VPAFGPPLPN
PPVFQKGPEF REFLLTKLTN AENACCKSDK FAKLEDRTRA ALLDNLHDEL HMHTQAMLGL
GPEEDKFENG GHGGFLESFK RAIRVRSHSM ETMVGGQRKL HGGGIPGSLS GGIVHNSMEV
TKTTFSPPVA VATVKNQSRS PIKRRSGLFP RLHTGSEGQG DSRTRCDSAS STPKTPDGAH
SSQEIKSETS SNPSSPEICP NKEKPFIKLK ENGRANISRS SSSTSSFSST AGEGEAMEDC
DSGSSQPSTT SPFKQDVFFY SQSSSSESPG MGAAATPIIM SRSPTDAKSR NSPRSNLKFR
FDKLSHASSS GGH
//
