ID A0A286Y4B4_CAVPO Unreviewed; 731 AA.
AC A0A286Y4B4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=RAP1 GTPase activating protein 2 {ECO:0000313|Ensembl:ENSCPOP00000032346.1};
GN Name=RAP1GAP2 {ECO:0000313|Ensembl:ENSCPOP00000032346.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000032346.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000032346.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000032346.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02033256; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02033257; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_013007652.1; XM_013152198.1.
DR AlphaFoldDB; A0A286Y4B4; -.
DR Ensembl; ENSCPOT00000036542.1; ENSCPOP00000032346.1; ENSCPOG00000000079.4.
DR VEuPathDB; HostDB:ENSCPOG00000000079; -.
DR GeneTree; ENSGT00940000160935; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000000079; Expressed in frontal cortex and 11 other cell types or tissues.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15711:SF17; RAP1 GTPASE-ACTIVATING PROTEIN 2; 1.
DR Pfam; PF21022; Rap-GAP_dimer; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW ProRule:PRU00165}; Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 248..464
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 554..731
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 575..616
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 632..650
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 659..689
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 731 AA; 80508 MW; 9643377F17EA42A6 CRC64;
MFGRKRSVSF GGFGWIDKTM LAGLKVKKQE LANSSDVTLP DQPLSPPLTA PPTMKSAEFF
EMLEKMQGIK LEEQRPGPQK NKDDYIPYPS IDEVVEKGGP YPLIILPQFG GYWIEDPENV
GTPTSLGSSI CEEEEEDGLS PNTFGYKLEC KGEARAYRRH FLGKDHLNFY CTGSSLGNLI
LSIKCEEVEG IEYLRIILRS KLKTVHERIP LAGLSKLPSV PQIAKAFCDD AVGLKFNPVL
YPKASQMIVS YDEHDVNNTF KFGVIYQKAR QTLEEELFWN NEESPAFKEF LDLLGDTITL
QDFKGFRGGL DVTHGQTGVE SVYTTFRDRE IMFHVSTKLP FTEGDAQQLQ RKRHIGNDIV
AIIFQEENTP FVPDMIASNF LHAYIVVQVE SPGTEIPSYK VSVTAREDVP AFGPPLPNPP
VFQKGPEFRE FLLTKLTNAE NACCKSDKFA KLEDRTRAAL LDNLHDELHM HTQAMLGLGP
EEDKFENGGH GGFLESFKRA IRVRSHSMET MVGGQRKLHG GGIPGSLSGG IVHNSMEVTK
TTFSPPVAVA TVKNQSRSPI KRRSGLFPRL HTGSEGQGDS RTRCDSASST PKTPDGAHSS
QEIKSETSSN PSSPEICPNK EKPFIKLKEN GRANISRSSS STSSFSSTAG EGEAMEDCDS
GSSQPSTTSP FKQDVFFYSQ SSSSESPGMG AAATPIIMSR SPTDAKSRNS PRSNLKFRFD
KLSHASSSGG H
//
