ID A0A286Y4K8_CAVPO Unreviewed; 1470 AA.
AC A0A286Y4K8;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=SH3 and multiple ankyrin repeat domains 2 {ECO:0000313|Ensembl:ENSCPOP00000032767.1};
GN Name=SHANK2 {ECO:0000313|Ensembl:ENSCPOP00000032767.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000032767.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000032767.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000032767.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Postsynaptic density
CC {ECO:0000256|ARBA:ARBA00034105}.
CC -!- SIMILARITY: Belongs to the SHANK family.
CC {ECO:0000256|ARBA:ARBA00010508}.
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DR EMBL; AAKN02038588; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02038589; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003468379.1; XM_003468331.3.
DR Ensembl; ENSCPOT00000048078.1; ENSCPOP00000032767.1; ENSCPOG00000009737.4.
DR GeneID; 100732196; -.
DR KEGG; cpoc:100732196; -.
DR CTD; 22941; -.
DR VEuPathDB; HostDB:ENSCPOG00000009737; -.
DR GeneTree; ENSGT00940000153561; -.
DR OrthoDB; 2247290at2759; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000009737; Expressed in frontal cortex and 11 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0120025; C:plasma membrane bounded cell projection; IEA:UniProt.
DR GO; GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
DR GO; GO:0050808; P:synapse organization; IEA:UniProt.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd09506; SAM_Shank1_2_3; 1.
DR CDD; cd11983; SH3_Shank2; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR24135; SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN; 1.
DR PANTHER; PTHR24135:SF17; SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN 2; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00454; SAM; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 147..206
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 247..341
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1407..1470
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 71..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 499..529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 653..912
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 942..994
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1052..1149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1195..1215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1254..1337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1376..1397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 505..529
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 656..679
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 808..822
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 893..912
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1062..1097
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1124..1148
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1197..1211
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1281..1332
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1381..1397
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1470 AA; 158659 MW; 41DD6A4F192CF714 CRC64;
MKSLLNAFTK KEVPFREAPA YSNRRRRPPN TLAAPRVLLR SNSDNNLHAG APEWAVCSAA
TAHRSLSPQL LQQVPSKPDG TVKSIPSYVP GPRSRSPSLN RLGGTGEDGK RPQPHWHVGP
PLTPGANKGS LSAFEYPGPK RKLYSAVPGR LFVVVKPYQP QVDGEIPLHR GDRVKVLSIG
EGGFWEGSAR GHIGWFPADC VEEVQCKPKD GQAETRADRS KKLFRHYTVG SYDSLDASGD
CIIEEKTVVL QKKDNEGFGF VLRGAKADTP IEEFTPTPAF PALQYLESVD EGGVAWQAGL
RTGDFLIEVN NENVVKVGHR QVVNMIRQGG NHLILKVVTV TRNLDPDDTA RKKAPPPPKR
APTTALTLRS KSMTAELEEL VDKAAVRKKK DKPEEIVPAP KPSRTAENVA VESRVATIKQ
RPTSRCFPAV SDMNSVYERQ GIAVMTPTVP GSPKGPFLGL PRGTMRRQKS IDSRIFLSGI
TEEERQFLAP PMLKFTRSLS MPDTSEDIPP PPQSVPPSPP PPSPTTYNCP KSPTPRVYGT
IKPAFNPNSA AKVSPATRSD TVATMMREKG MFYRRELDRY SLDSEDLYSR NAPPQATFRT
KRGQMPENPY SEVGKIASKA VYVPAKPARR KGMLVKQSNV EDSPEKTCSI PIPTIIVKEP
STSSSGKSSQ GSSMEIDPQV TEPPGQLRPD DSLTVSSPFA AAIAGAVRDR EKRLEARRNS
PAFLSTDLGD EDVGLGPPIP RVRPSKFPEE GGFGDEDGSE QLVSPTPGAS PREPENHFMG
SGEAGAQAEA GRPLNSASKA KGPEGSTAAP PKSSSTASPE NYVHPLTGRL LDPSSPLALA
LSARDRALKE SQQGPKGEAP KADLNKPLYI DTKMRPSVEA GFPPVTRQNT RGPLRRQETE
NKYELDLSKD RRGEDKKNML INIVDTAQQK TAGLLMVHTV DATKTGGPLE EEEEREDVDI
KPDNLPSTVP EGVSETEGAL QISAAPEPTT TPGRTIVAAG SMEEAVVLPF RIPPPPLASV
DLDEDFIFTE PLPPPLEFAN SFDIPDDRAA SVPALTDLAK QKKSDTPPSP SWNAGQPASS
TDSKKPASLS NCLPTSFLPP PESFDAVTDS GIEEVDSRSS SDHHLETTST ISTVSSISTL
SSEGGESMDT CTVYADGQAF VVDKPPVPPK PKMKPIIHKS NALYQDALLE EDVDSFVIPP
PAPPPPPGST QPGMAKVIQP RTSKLWGDVT EVKSPILSGP KANVISELNS ILQQMNREKS
AKPGEGLDSP AGAKSASLPP RSLEVMSTVS GTRSTTVTFT VRPGTSQPIT LQSRPPDYES
RTSGTRRAPS PVVSPTEMNK EILPTPLSAA AASPSPTLSD VFSLPSQSPA GDLFGLNPAG
RSRSPSPSIL QQPISNKPFT TKPVHLWTKP DVADWLESLN LGEHKETFMD NEIDGSHLPN
LQKEDLIDLG VTRVGHRMNI ERALKQLLDR
//
