ID A0A286Y5M8_CAVPO Unreviewed; 121 AA.
AC A0A286Y5M8;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Eukaryotic translation initiation factor 4E binding protein 2 {ECO:0000313|Ensembl:ENSCPOP00000033134.1};
GN Name=EIF4EBP2 {ECO:0000313|Ensembl:ENSCPOP00000033134.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000033134.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000033134.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000033134.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the eIF4E-binding protein family.
CC {ECO:0000256|ARBA:ARBA00005480}.
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DR EMBL; AAKN02021224; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02021225; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A286Y5M8; -.
DR STRING; 10141.ENSCPOP00000033134; -.
DR Ensembl; ENSCPOT00000046943.1; ENSCPOP00000033134.1; ENSCPOG00000039594.1.
DR VEuPathDB; HostDB:ENSCPOG00000039594; -.
DR eggNOG; ENOG502S44S; Eukaryota.
DR GeneTree; ENSGT00940000155342; -.
DR InParanoid; A0A286Y5M8; -.
DR OMA; PMMTRKI; -.
DR OrthoDB; 2911937at2759; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000039594; Expressed in uterine cervix and 13 other cell types or tissues.
DR GO; GO:0071598; C:neuronal ribonucleoprotein granule; IEA:Ensembl.
DR GO; GO:0008190; F:eukaryotic initiation factor 4E binding; IEA:Ensembl.
DR GO; GO:0030371; F:translation repressor activity; IEA:Ensembl.
DR GO; GO:0008286; P:insulin receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0007613; P:memory; IEA:Ensembl.
DR GO; GO:0045947; P:negative regulation of translational initiation; IEA:Ensembl.
DR GO; GO:0048167; P:regulation of synaptic plasticity; IEA:Ensembl.
DR GO; GO:0035176; P:social behavior; IEA:Ensembl.
DR GO; GO:0031929; P:TOR signaling; IEA:Ensembl.
DR InterPro; IPR008606; EIF4EBP.
DR PANTHER; PTHR12669; EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN; 1.
DR PANTHER; PTHR12669:SF4; EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 2; 1.
DR Pfam; PF05456; eIF_4EBP; 1.
PE 3: Inferred from homology;
KW Protein synthesis inhibitor {ECO:0000256|ARBA:ARBA00023193};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845}.
FT REGION 99..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..121
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 121 AA; 13439 MW; 1D7D7B3239EEC42E CRC64;
MFFVRRERPP SPAQSRAIPT RTVPISDAAQ LPHDYCTTPG GTLFSTTPGG TRIIYDRKFL
LDRRNSPMAQ TPPCHLPNIP GVTSPGTLIE DSKVEVNNLN NLNNHDRKHA VGDDSQFEMD
I
//
