ID A0A286Y8J7_DANRE Unreviewed; 2675 AA.
AC A0A286Y8J7;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 10-FEB-2021, entry version 16.
DE SubName: Full=Centromere protein F {ECO:0000313|Ensembl:ENSDARP00000143468};
GN Name=cenpf {ECO:0000313|Ensembl:ENSDARP00000143468,
GN ECO:0000313|ZFIN:ZDB-GENE-041111-205};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000143468, ECO:0000313|Proteomes:UP000000437};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000143468, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000143468,
RC ECO:0000313|Proteomes:UP000000437};
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000143468}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000143468};
RG Ensembl;
RL Submitted (OCT-2017) to UniProtKB.
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DR EMBL; BX936381; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSDART00000176858; ENSDARP00000143468; ENSDARG00000055133.
DR ZFIN; ZDB-GENE-041111-205; cenpf.
DR GeneTree; ENSGT00730000111187; -.
DR OMA; YNAQLVQ; -.
DR Proteomes; UP000000437; Chromosome 17.
DR ExpressionAtlas; A0A286Y8J7; baseline.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:InterPro.
DR GO; GO:0070840; F:dynein complex binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:InterPro.
DR GO; GO:0008134; F:transcription factor binding; IEA:InterPro.
DR GO; GO:0060271; P:cilium assembly; IMP:ZFIN.
DR InterPro; IPR043513; Cenp-F.
DR InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR InterPro; IPR018463; Centromere_CenpF_N.
DR PANTHER; PTHR18874; PTHR18874; 2.
DR Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR Pfam; PF10473; CENP-F_leu_zip; 2.
DR Pfam; PF10481; CENP-F_N; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Proteomics identification {ECO:0000213|PeptideAtlas:A0A286Y8J7};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 1..295
FT /note="CENP-F_N"
FT /evidence="ECO:0000259|Pfam:PF10481"
FT DOMAIN 1674..1814
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 1912..2050
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2529..2573
FT /note="CENP-F_C_Rb_bdg"
FT /evidence="ECO:0000259|Pfam:PF10490"
FT REGION 47..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 126..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 208..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 366..390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1433..1452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2402..2540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2582..2627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2642..2675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 161..181
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 268..330
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 536..577
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 585..605
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 609..675
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 708..742
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 792..826
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 841..882
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 918..976
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1015..1070
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1082..1109
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1145..1214
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1236..1277
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1306..1392
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1499..1537
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1606..1656
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1678..1726
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1755..1845
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1888..2027
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2070..2090
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2098..2129
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2137..2157
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2165..2199
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2239..2266
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 49..70
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..156
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..228
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 366..386
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2402..2418
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2419..2458
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2459..2474
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2526..2540
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2650..2675
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2675 AA; 307391 MW; 0EBDF2913C2ACBE8 CRC64;
MSWAVEEWKD GLPAKALQKI QEIEAQLDKL KKERQQKQFQ MDSLEATLQK QKQKMDSEKS
EASALKRENQ SLVESCEHLE KARQKLTHDI QTKEQQVNYL EGQLNSFKKQ TDRLEQEVKK
YKHELERSQT SHASEIQQLS TPQKTFATPA TPNHWQQDSK ITDLQEKYNR EVEERKKLEA
EIKVMHVKLL NQSSVSHKDI ARQQTGSSIF PWQQDQKSSH QSLPVMETPS RRRNGASGMP
WSYDDTPIKP HQQFTSGAPS DTVGSQQMEQ LKNINQDLRS KVSELELRLQ AHEKDMKNQI
NKFSEIQSQL EMAKKDVAEK DKLLNKSRDE LTKATGQYEQ SVSKCSAFEI KLKQVTEEMN
CQRHNAESMH RSLEQKIKDQ ERESQKELAQ LQSSYQALDQ QFTQVKNKTS MEIQQAKKDH
NVLQSEMDKV TALKNRLEKE LEELKQKLLR SEQALQASQV KEAETKKKFE EMQREKNTLN
CQLDQGMKRV KQLEDEKQNT EQILAKNRMM VDDLKVKTQT QNEELTELRK KMDHQSVSSA
QELENLKKTL IEAEAKNMKT QAELQKLVHD VELKENKICA VEKENEELKM TSNSCQKELA
EMKKEYDALL QWKTEKEQLI NNAESNRNEL LAKVADLEKD KDNLSNAHGD LQKKMQDLEN
EKIGLSGQID SLKGELLVKC VELEEKGRVY EELQQQFGET KIKHKKEMDN LNQQITLTQG
KVSELEAKLL QETSKLEGME QAHGQLLAEY ESACILAMSK DSIIEMNKTE IVHLQESFTL
RDQELEKFKV EKDILAKECE DRLAQNKELE QQKLNTETSL MEVLAKFTLL ESDLRCQKDL
NAEIQGKYDE LSKIKEDLVE KVSSLEKREK DLINEVESLL QKNKSLCSLE EQFNCLVAEA
EETRSSLEKV KELQVQTTTE LENQKTIAEN LAIDLEEEKK KALSIKQENT QLKVKQEEIE
NKANDLFEKY ESLQKLHDAV CQENANHLKE ISIVTEALAE KDAMAERIAL IKTELETSNN
LSATLKNSLE NLQTQFDSSV ELISSLEKKL HDMSDEKSLL EISIKELTER HNKESEVYVS
ELETHIKKHK SLEEHISVLE TELQNKSLET KTASEKLEVT TQEMIKLKQD FSLSENKLSV
VTDSNKKVAK ELEDMKQNVF LQEQEMEGLR LALSDLKNQE AAKSCEIETL KEKLQKAQSE
HAKTSETLNE KNINMSKIKV QLEMLQMDLE DNENCINAFD AQVEELQGNV SILEAKLSES
EAQRSNLESK LESVKEDYVK SSLEVSQLSA CLEESQKEQQ SRSVLVAELE SLRVIHEQLK
VSLEQENCKQ ANLEAMYTNL MDQKLKLESE IQELKADTQG SQKQIDQLKQ ANDRLASQIA
EQQIHIEQLQ SEKNLADTLN KEQTSGGNDQ DICEMPFANT SLLPFEEDTA ILGMSSPKGK
HDSQEEPKTP LSAEEDYKDF ALQEQMQNKS SDIEDMSHVL KETVRTMEEQ TAIQIEQLKL
QHATELQSME EQMLNIKNEL EAKLKEEKQH TEILSSQLEA TMQQLQELDI ASSSLLAADT
SQNMGKFASG AQDDLIHHTE QSNSTLGIIT ESEHSNLETE TLKEVLRKRE EELLHLQSQF
EVLESEMENE KLNKHIGELK EEIDSLTLQL QTSNCQLTDV MEMMESLEMA KGEWNEKFFQ
IESELKRVRS EKANLEKHIL SMEADIEEMQ EQKQKQEAEL ETARRTNCSL EQQLNITMAE
GGRLKEELIL CTDERESETH SLMKLKEKAD LLEKRETDTK ELIKELEDDI RVGKKQNEVA
SDQISVLLKE KEQLIQQSQN LENKIVLLNE DNERLLSELN DIKHNDSFTS RETENMSSKI
HSLEDENVRL SQSLEMSLLE KGEIASRLIS TQEEVAQMRQ GIEKLKVRIE SDERKKNHMS
QLLKAAQRKA DVLQDNIEKL EREKELSEQN LEDAILQAET AKAELEEIQA ETQDLTKKIE
EMTSELKDLK EEKYKLEQEL DQKNKLIEEL QLSIQEASVK LKSAEEATLN QEQMIKDFQF
KVGAMEEELR LFQTEVESKE VKALELASHL LSLESENKEF AQRVLEYERS QEELHSSNQS
LLKDFESKQQ ELSEENTQLR SQIAELQALS LIREEQDEEL QKDKVELQST IAQLEEKTQM
QSTKMEVMQN SISSLEINIQ QLEGQLDAMK LMNVELTGKL NSLQESSLHL ETQHKQELCE
AKEIQNALEI NQNLLTCQLQ ESQKQIEEYK FSLEALAAEK DGLQKSISVI QESHDVQLKE
NNMRHEENLK RTQQQLEVEL NALKENILVA EKNAAQYQSD LESIKSQNAE KDSALKELQN
KWENCQKEKA ELDSKITRLS KEKDSAMSKI NLWMKSCKQL ENEKQTLQEE LQQQGQEIET
LKASKEQAEG SSSSGALQEE LEELKEALEE KSREADDSMD RYCSLMVKVH KLEDSNESLK
NQLKQLSTQT KTPKSRRSLR SETSDLENSN PEGVTSGKRQ RAIDDTPNKA QEALHNITKR
LKAAAATPKA KQDDEDFRPE GLPELVQKGF ADIPVGEMSP FIVRRTTAQR CSPRLAARTT
AVLQSSGSAE HPAQISMQTA EGRTPNTVQK PKATPSRNVP LLSTLTNSPL KNSCERLAPV
IEQKISRRSR SFKNSPQTSE QVTASPKQND NCQVQ
//
