ID A0A286YA23_DANRE Unreviewed; 1259 AA.
AC A0A286YA23; A0A8M6YZS8;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 2.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Cell adhesion molecule L1-like b {ECO:0000313|Ensembl:ENSDARP00000144053};
DE SubName: Full=Neural cell adhesion molecule L1-like protein isoform X5 {ECO:0000313|RefSeq:XP_017212180.2};
GN Name=chl1b {ECO:0000313|Ensembl:ENSDARP00000144053,
GN ECO:0000313|RefSeq:XP_017212180.2,
GN ECO:0000313|ZFIN:ZDB-GENE-091105-1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000144053};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000144053, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000144053};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000144053}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000144053};
RG Ensembl;
RL Submitted (OCT-2017) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_017212180.2}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_017212180.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily.
CC L1/neurofascin/NgCAM family. {ECO:0000256|ARBA:ARBA00008588}.
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DR EMBL; BX322791; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CU075711; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; FO904890; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; LO017920; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; LO018660; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_017212180.2; XM_017356691.2.
DR PaxDb; 7955-ENSDARP00000103349; -.
DR Ensembl; ENSDART00000175473; ENSDARP00000144053; ENSDARG00000103109.
DR Ensembl; ENSDART00000175473.2; ENSDARP00000144053.2; ENSDARG00000103109.3.
DR AGR; ZFIN:ZDB-GENE-091105-1; -.
DR ZFIN; ZDB-GENE-091105-1; chl1b.
DR eggNOG; KOG3513; Eukaryota.
DR Proteomes; UP000000437; Chromosome 6.
DR Bgee; ENSDARG00000103109; Expressed in brain and 16 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 5.
DR Gene3D; 2.60.40.10; Immunoglobulins; 11.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR026966; Neurofascin/L1/NrCAM_C.
DR PANTHER; PTHR44170:SF51; NEURAL CELL ADHESION MOLECULE L1-LIKE PROTEIN ISOFORM X1; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF13882; Bravo_FIGEY; 1.
DR Pfam; PF00041; fn3; 4.
DR Pfam; PF07679; I-set; 4.
DR Pfam; PF13927; Ig_3; 1.
DR SMART; SM00060; FN3; 5.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 5.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS50835; IG_LIKE; 6.
PE 1: Evidence at protein level;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A286YA23};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..1259
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041060974"
FT TRANSMEM 1138..1159
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 42..133
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 137..230
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 259..347
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 352..439
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 445..532
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 536..629
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 634..729
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 734..827
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 832..934
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 938..1034
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 713..735
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1195..1225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 713..727
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1259 AA; 140583 MW; F6EF63CD9930001C CRC64;
MRLLRKTLLL LAACLNMSSR YQTNALEIPL DVLERMNMEQ LPTITEYSPA SLIAFPFEES
FPVKCEATGN PEPEFRWTKN GQDFDPYQDT RLITLDDSGT FIIPNTGNLT EFQGIYRCFA
TNKLGTAMSE EIEFIIPNVP KFPKEIIDPI EVMEGQSVIL ECNPPTGIPP LQIYWMTISL
QHIEQDERVS VGLNGNLYFS NTVETDSRRD YCCFAAFPRI RTIVQKTAMS MVVKSNKLMK
DSSSGSGRGY ANSLLERKPS LLAPTGMESH TRLVKGEDLQ LECIAEGFPT PKVEWVKIGF
NKLPERVVVE SHGKLLTVEM VNEEDEGKYM CRAKNPHGEV VHHFHVTVEE PPEFEIEPQS
QLVTIGADVL IKCVVKGNPQ PTVGWRVNGR PLNEVPTSNR KILKDGTISI HNANPENSAV
YQCEATNKHG TILANANIMI MNIQPLILTE NNLQYMAVEG KSVVMHCKVF SSPASSITWS
KADSANAVEG ERFTVHQNGS LEIHNVMKED MGEYSCFAQN TEGKVAIAAT LEVKDPTRIV
DPPRDLRVLA GTTIQFSCQP EFDPSFGDDF EVLWEKDGIA LNGSEDGRYI LEDGVLEIIN
VSFGDQGFYA CVARTPVDQD VAVAQLSVVD VPDPPEDVIL SEHNGRSVKL QWTPGDDHNS
SITEFVLEFE ESQHEPGSWR EMMRVPGNHH SAPLKLYGHV DYRFRVSAIN EVGKGRPSQS
TERYKTPASA PDKNPENIKI EAHLPHEMDI NWEPLSPIEH NGPGLEYKVS YRRHGSDEDW
TERMVKRHSF LVKNTPTFVL YEIKIQAKNH AGWGPDPKII TAYSGEDFPS AAPDDVAVEV
LNNTMVKVRW EHVHKDKIHG HLGGYRVSWW RLRSLLDSKK THGDKHTLTF SGERNHAVVT
GLKPFSEYSL IVMAFNSRGN GPGSHSVNFK TPEGVPGQAA AFSATNIQKH KVTLTWSPPV
DANGVLIGYI LQYQLINNTE ELGPLMTLNI SADSNKQHLE NLEALSKYKF YLRCCTRVGC
GPAVSEERTT VPEATVLNIS TSVSHNYANI SWIPGTEQTE SELYVAFMNN REGNWKISDM
LNSSKTFHII EGLEPGTEYT VRLMTKSWVD NSSIFEDVIR TRAKGLASIH GSISNQGWFI
GLMCAIALLT LIVLIACFVN RNKGGKYSVK EKEDLHPDLE SQGINDDTFC EYSDNDEKPL
KSSQHSLNGD LKGGDSGDSM VDYCDEDAHF NEDGSFIGEY SGRKDRASME IKGNNQSTA
//
