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Database: UniProt
Entry: A0A286YF46
LinkDB: A0A286YF46
Original site: A0A286YF46 
ID   SCGR5_HUMAN             Reviewed;          85 AA.
AC   A0A286YF46;
DT   10-OCT-2018, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2017, sequence version 1.
DT   16-JAN-2019, entry version 6.
DE   RecName: Full=Small cysteine and glycine repeat-containing protein 5 {ECO:0000305};
DE   AltName: Full=Keratin-associated protein 28-5 {ECO:0000303|PubMed:18721477};
GN   Name=SCYGR5 {ECO:0000312|HGNC:HGNC:34224};
GN   Synonyms=KRTAP28-5 {ECO:0000303|PubMed:18721477};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2]
RP   FAMILY CHARACTERIZATION.
RX   PubMed=18721477; DOI=10.1186/1471-2148-8-241;
RA   Wu D.D., Irwin D.M., Zhang Y.P.;
RT   "Molecular evolution of the keratin associated protein gene family in
RT   mammals, role in the evolution of mammalian hair.";
RL   BMC Evol. Biol. 8:241-241(2008).
CC   -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments
CC       are embedded in an interfilamentous matrix, consisting of hair
CC       keratin-associated proteins (KRTAP), which are essential for the
CC       formation of a rigid and resistant hair shaft through their
CC       extensive disulfide bond cross-linking with abundant cysteine
CC       residues of hair keratins. The matrix proteins include the high-
CC       sulfur and high-glycine-tyrosine keratins. {ECO:0000305}.
CC   -!- MISCELLANEOUS: Human have a similar number of genes as other
CC       primates despite the relative hairlessness of humans.
CC       {ECO:0000303|PubMed:18721477}.
CC   -!- SIMILARITY: Belongs to the KRTAP type 28 family.
CC       {ECO:0000305|PubMed:18721477}.
DR   EMBL; AC064853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   BioMuta; ENSG00000284667; -.
DR   Ensembl; ENST00000641976; ENSP00000493101; ENSG00000284667.
DR   GeneCards; SCYGR5; -.
DR   HGNC; HGNC:34224; SCYGR5.
DR   GeneTree; ENSGT00910000147673; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Complete proteome; Keratin; Reference proteome; Repeat.
FT   CHAIN         1     85       Small cysteine and glycine repeat-
FT                                containing protein 5.
FT                                /FTId=PRO_0000445145.
FT   REGION        4     69       10 X 2 AA repeats of CG. {ECO:0000305}.
FT   COMPBIAS      2     21       Gly-rich. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00008}.
FT   COMPBIAS      3     85       Cys-rich. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00005}.
SQ   SEQUENCE   85 AA;  8201 MW;  4C0D5D13F856CC8F CRC64;
     MGCCGCGGCG GCGGGCGGGC GSCTTCRCYR VGCCSSCCPC CRGCCGGCCS TPVICCCRRT
     CCSCGCGCGK GCCQQKGCCQ KQCCC
//
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