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Database: UniProt
Entry: A0A286YF60
LinkDB: A0A286YF60
Original site: A0A286YF60 
ID   SCGR3_HUMAN             Reviewed;         100 AA.
AC   A0A286YF60;
DT   10-OCT-2018, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2017, sequence version 1.
DT   10-APR-2019, entry version 7.
DE   RecName: Full=Small cysteine and glycine repeat-containing protein 3 {ECO:0000305};
DE   AltName: Full=Keratin-associated protein 28-3 {ECO:0000303|PubMed:18721477};
GN   Name=SCYGR3 {ECO:0000312|HGNC:HGNC:34222};
GN   Synonyms=KRTAP28-3 {ECO:0000303|PubMed:18721477};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2]
RP   FAMILY CHARACTERIZATION.
RX   PubMed=18721477; DOI=10.1186/1471-2148-8-241;
RA   Wu D.D., Irwin D.M., Zhang Y.P.;
RT   "Molecular evolution of the keratin associated protein gene family in
RT   mammals, role in the evolution of mammalian hair.";
RL   BMC Evol. Biol. 8:241-241(2008).
CC   -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments
CC       are embedded in an interfilamentous matrix, consisting of hair
CC       keratin-associated proteins (KRTAP), which are essential for the
CC       formation of a rigid and resistant hair shaft through their
CC       extensive disulfide bond cross-linking with abundant cysteine
CC       residues of hair keratins. The matrix proteins include the high-
CC       sulfur and high-glycine-tyrosine keratins. {ECO:0000305}.
CC   -!- MISCELLANEOUS: Human have a similar number of genes as other
CC       primates despite the relative hairlessness of humans.
CC       {ECO:0000303|PubMed:18721477}.
CC   -!- SIMILARITY: Belongs to the KRTAP type 28 family.
CC       {ECO:0000305|PubMed:18721477}.
DR   EMBL; AC064853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   BioMuta; ENSG00000284704; -.
DR   Ensembl; ENST00000642029; ENSP00000493170; ENSG00000284704.
DR   GeneCards; SCYGR3; -.
DR   HGNC; HGNC:34222; SCYGR3.
DR   GeneTree; ENSGT00950000183380; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Complete proteome; Keratin; Reference proteome; Repeat.
FT   CHAIN         1    100       Small cysteine and glycine repeat-
FT                                containing protein 3.
FT                                /FTId=PRO_0000445143.
FT   REGION        4     82       13 X 2 AA repeats of CG. {ECO:0000305}.
FT   COMPBIAS      2     36       Gly-rich. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00008}.
FT   COMPBIAS      3    100       Cys-rich. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00005}.
SQ   SEQUENCE   100 AA;  9511 MW;  7785E95F5067EBD5 CRC64;
     MGCCGCGSCG GCGGGCGGCG GGCGGGCGGG CGGVCGSCTT CRCYRVGCCS SCCPCCRGCC
     GGCCSTPVIC CCRRTCRSCG CGCRKGCCQQ KCCCQKQCCC
//
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