ID SCGR3_HUMAN Reviewed; 100 AA.
AC A0A286YF60;
DT 10-OCT-2018, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Small cysteine and glycine repeat-containing protein 3 {ECO:0000305};
DE AltName: Full=Keratin-associated protein 28-3 {ECO:0000303|PubMed:18721477};
GN Name=SCYGR3 {ECO:0000312|HGNC:HGNC:34222};
GN Synonyms=KRTAP28-3 {ECO:0000303|PubMed:18721477};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2]
RP FAMILY CHARACTERIZATION.
RX PubMed=18721477; DOI=10.1186/1471-2148-8-241;
RA Wu D.D., Irwin D.M., Zhang Y.P.;
RT "Molecular evolution of the keratin associated protein gene family in
RT mammals, role in the evolution of mammalian hair.";
RL BMC Evol. Biol. 8:241-241(2008).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins. {ECO:0000305}.
CC -!- MISCELLANEOUS: Human have a similar number of genes as other primates
CC despite the relative hairlessness of humans.
CC {ECO:0000303|PubMed:18721477}.
CC -!- SIMILARITY: Belongs to the KRTAP type 28 family.
CC {ECO:0000305|PubMed:18721477}.
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DR EMBL; AC064853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS92954.1; -.
DR AlphaFoldDB; A0A286YF60; -.
DR BioMuta; ENSG00000284704; -.
DR MassIVE; A0A286YF60; -.
DR PeptideAtlas; A0A286YF60; -.
DR Ensembl; ENST00000642029.1; ENSP00000493170.1; ENSG00000284704.1.
DR MANE-Select; ENST00000642029.1; ENSP00000493170.1; NM_001395404.1; NP_001382333.1.
DR AGR; HGNC:34222; -.
DR GeneCards; SCYGR3; -.
DR HGNC; HGNC:34222; SCYGR3.
DR HPA; ENSG00000284704; Not detected.
DR neXtProt; NX_A0A286YF60; -.
DR VEuPathDB; HostDB:ENSG00000284704; -.
DR GeneTree; ENSGT00950000183380; -.
DR InParanoid; A0A286YF60; -.
DR OMA; CRKGCCQ; -.
DR Pharos; A0A286YF60; Tdark.
DR PRO; PR:A0A286YF60; -.
DR Proteomes; UP000005640; Chromosome 2.
DR Bgee; ENSG00000284704; Expressed in skin of abdomen and 23 other cell types or tissues.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..100
FT /note="Small cysteine and glycine repeat-containing protein
FT 3"
FT /id="PRO_0000445143"
FT REGION 4..82
FT /note="13 X 2 AA repeats of CG"
FT /evidence="ECO:0000305"
SQ SEQUENCE 100 AA; 9511 MW; 7785E95F5067EBD5 CRC64;
MGCCGCGSCG GCGGGCGGCG GGCGGGCGGG CGGVCGSCTT CRCYRVGCCS SCCPCCRGCC
GGCCSTPVIC CCRRTCRSCG CGCRKGCCQQ KCCCQKQCCC
//
