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Database: UniProt
Entry: A0A286YFB4
LinkDB: A0A286YFB4
Original site: A0A286YFB4 
ID   SCGR2_HUMAN             Reviewed;         120 AA.
AC   A0A286YFB4;
DT   10-OCT-2018, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2017, sequence version 1.
DT   10-APR-2019, entry version 8.
DE   RecName: Full=Small cysteine and glycine repeat-containing protein 2 {ECO:0000305};
DE   AltName: Full=Keratin-associated protein 28-2 {ECO:0000303|PubMed:18721477};
GN   Name=SCYGR2 {ECO:0000312|HGNC:HGNC:34220};
GN   Synonyms=KRTAP28-2 {ECO:0000303|PubMed:18721477};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2]
RP   FAMILY CHARACTERIZATION.
RX   PubMed=18721477; DOI=10.1186/1471-2148-8-241;
RA   Wu D.D., Irwin D.M., Zhang Y.P.;
RT   "Molecular evolution of the keratin associated protein gene family in
RT   mammals, role in the evolution of mammalian hair.";
RL   BMC Evol. Biol. 8:241-241(2008).
CC   -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments
CC       are embedded in an interfilamentous matrix, consisting of hair
CC       keratin-associated proteins (KRTAP), which are essential for the
CC       formation of a rigid and resistant hair shaft through their
CC       extensive disulfide bond cross-linking with abundant cysteine
CC       residues of hair keratins. The matrix proteins include the high-
CC       sulfur and high-glycine-tyrosine keratins. {ECO:0000305}.
CC   -!- MISCELLANEOUS: Human have a similar number of genes as other
CC       primates despite the relative hairlessness of humans.
CC       {ECO:0000303|PubMed:18721477}.
CC   -!- SIMILARITY: Belongs to the KRTAP type 28 family.
CC       {ECO:0000305|PubMed:18721477}.
DR   EMBL; AC064853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   BioMuta; ENSG00000284643; -.
DR   Ensembl; ENST00000641394; ENSP00000493300; ENSG00000284643.
DR   GeneCards; SCYGR2; -.
DR   HGNC; HGNC:34220; SCYGR2.
DR   GeneTree; ENSGT00950000183469; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Complete proteome; Keratin; Reference proteome; Repeat.
FT   CHAIN         1    120       Small cysteine and glycine repeat-
FT                                containing protein 2.
FT                                /FTId=PRO_0000445142.
FT   REGION        4    104       19 X 2 AA repeats of CG.
FT   COMPBIAS      2     56       Gly-rich. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00008}.
FT   COMPBIAS      3    120       Cys-rich. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00005}.
SQ   SEQUENCE   120 AA;  10822 MW;  13E24D235A63C9D8 CRC64;
     MGCCGCGGCG GCGGRCGGCG GGCGGGCGGG CGGGCGGGCG GGCGGGCGGG CGGSCGSCTT
     CRCYRVGCCS SCCPCCRGCC GGCCSTPVIC CCRRTCHSCG CGCGKGCCQQ KCCCQKQCCC
//
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