ID A0A286ZJM0_PIG Unreviewed; 351 AA.
AC A0A286ZJM0;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 2.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Fibronectin type-III domain-containing protein {ECO:0000259|PROSITE:PS50853};
GN Name=LOC102161330 {ECO:0000313|Ensembl:ENSSSCP00000031653.2};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000031653.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000031653.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000031653.2};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000031653.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; A0A286ZJM0; -.
DR STRING; 9823.ENSSSCP00000031653; -.
DR PaxDb; 9823-ENSSSCP00000020470; -.
DR Ensembl; ENSSSCT00000051718.3; ENSSSCP00000031653.2; ENSSSCG00000036851.3.
DR eggNOG; ENOG502RZVR; Eukaryota.
DR GeneTree; ENSGT00520000055993; -.
DR InParanoid; A0A286ZJM0; -.
DR OrthoDB; 5353959at2759; -.
DR Proteomes; UP000008227; Unplaced.
DR Bgee; ENSSSCG00000036851; Expressed in blood and 7 other cell types or tissues.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR GO; GO:0019955; F:cytokine binding; IBA:GO_Central.
DR GO; GO:0004896; F:cytokine receptor activity; IBA:GO_Central.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR040907; IL3Ra_N.
DR InterPro; IPR003532; Short_hematopoietin_rcpt_2_CS.
DR InterPro; IPR015321; TypeI_recpt_CBD.
DR PANTHER; PTHR23037; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23037:SF28; ERYTHROPOIETIN RECEPTOR; 1.
DR Pfam; PF18611; IL3Ra_N; 1.
DR Pfam; PF09240; IL6Ra-bind; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS01356; HEMATOPO_REC_S_F2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..351
FT /note="Fibronectin type-III domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5036481395"
FT TRANSMEM 326..349
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 223..321
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
SQ SEQUENCE 351 AA; 39584 MW; 8DC8302AA90F4E37 CRC64;
MVSPLNFVSL LVLVNSACFV DSQLAQKESP IINTKLDKRK KILTWNSRRN VTQQECIIDI
PFEDPIRPTV EVSDDNSYAC TFVNHLVHRG ANLTVNVTAD GQVYQEFLTI PNPGKEGSGG
TNLSCLIYNI RFMNCSWMPG PAAPADVSYH LYMWASLHGN VSECSWYILD STGTRVGCHF
ENLDEPHNTD NYFFLLNGTS NETAIQFLDS IPFVGKDIEK YNPPANVSVT YNVSYYIIRW
DNPKIRFHLS HHILCYEVDV QRKGSVSKGE PVFQRGEDEN KYLLPGATVT GEHTLRVRVR
HAYGTMWSDW SAACSFGFPE KDFGRFLVIL VGLLVGAVAL FSMGLMFLCK R
//
