ID A0A286ZLP7_PIG Unreviewed; 223 AA.
AC A0A286ZLP7;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=26S proteasome non-ATPase regulatory subunit 9 {ECO:0000256|ARBA:ARBA00014937};
DE AltName: Full=26S proteasome regulatory subunit p27 {ECO:0000256|ARBA:ARBA00030007};
GN Name=PSMD9 {ECO:0000313|Ensembl:ENSSSCP00000032484.1,
GN ECO:0000313|VGNC:VGNC:111131};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000032484.1, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000032484.1, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000032484.1,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000032484.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the proteasome subunit p27 family.
CC {ECO:0000256|ARBA:ARBA00005256}.
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DR RefSeq; XP_003132922.1; XM_003132874.4.
DR AlphaFoldDB; A0A286ZLP7; -.
DR SMR; A0A286ZLP7; -.
DR STRING; 9823.ENSSSCP00000032484; -.
DR PaxDb; 9823-ENSSSCP00000010466; -.
DR Ensembl; ENSSSCT00000051138.3; ENSSSCP00000032484.1; ENSSSCG00000036483.3.
DR GeneID; 100525255; -.
DR KEGG; ssc:100525255; -.
DR CTD; 5715; -.
DR VGNC; VGNC:111131; PSMD9.
DR eggNOG; KOG3129; Eukaryota.
DR GeneTree; ENSGT00390000004147; -.
DR InParanoid; A0A286ZLP7; -.
DR OMA; DWGGRGM; -.
DR OrthoDB; 20876at2759; -.
DR Reactome; R-SSC-1169091; Activation of NF-kappaB in B cells.
DR Reactome; R-SSC-1234176; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
DR Reactome; R-SSC-1236978; Cross-presentation of soluble exogenous antigens (endosomes).
DR Reactome; R-SSC-174084; Autodegradation of Cdh1 by Cdh1:APC/C.
DR Reactome; R-SSC-174154; APC/C:Cdc20 mediated degradation of Securin.
DR Reactome; R-SSC-174178; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
DR Reactome; R-SSC-174184; Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
DR Reactome; R-SSC-187577; SCF(Skp2)-mediated degradation of p27/p21.
DR Reactome; R-SSC-195253; Degradation of beta-catenin by the destruction complex.
DR Reactome; R-SSC-202424; Downstream TCR signaling.
DR Reactome; R-SSC-2467813; Separation of Sister Chromatids.
DR Reactome; R-SSC-2871837; FCERI mediated NF-kB activation.
DR Reactome; R-SSC-349425; Autodegradation of the E3 ubiquitin ligase COP1.
DR Reactome; R-SSC-350562; Regulation of ornithine decarboxylase (ODC).
DR Reactome; R-SSC-382556; ABC-family proteins mediated transport.
DR Reactome; R-SSC-450408; AUF1 (hnRNP D0) binds and destabilizes mRNA.
DR Reactome; R-SSC-4608870; Asymmetric localization of PCP proteins.
DR Reactome; R-SSC-4641257; Degradation of AXIN.
DR Reactome; R-SSC-4641258; Degradation of DVL.
DR Reactome; R-SSC-5358346; Hedgehog ligand biogenesis.
DR Reactome; R-SSC-5607761; Dectin-1 mediated noncanonical NF-kB signaling.
DR Reactome; R-SSC-5607764; CLEC7A (Dectin-1) signaling.
DR Reactome; R-SSC-5610780; Degradation of GLI1 by the proteasome.
DR Reactome; R-SSC-5610785; GLI3 is processed to GLI3R by the proteasome.
DR Reactome; R-SSC-5632684; Hedgehog 'on' state.
DR Reactome; R-SSC-5658442; Regulation of RAS by GAPs.
DR Reactome; R-SSC-5668541; TNFR2 non-canonical NF-kB pathway.
DR Reactome; R-SSC-5676590; NIK-->noncanonical NF-kB signaling.
DR Reactome; R-SSC-5687128; MAPK6/MAPK4 signaling.
DR Reactome; R-SSC-5689603; UCH proteinases.
DR Reactome; R-SSC-5689880; Ub-specific processing proteases.
DR Reactome; R-SSC-68867; Assembly of the pre-replicative complex.
DR Reactome; R-SSC-68949; Orc1 removal from chromatin.
DR Reactome; R-SSC-69017; CDK-mediated phosphorylation and removal of Cdc6.
DR Reactome; R-SSC-69481; G2/M Checkpoints.
DR Reactome; R-SSC-69601; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
DR Reactome; R-SSC-75815; Ubiquitin-dependent degradation of Cyclin D.
DR Reactome; R-SSC-8852276; The role of GTSE1 in G2/M progression after G2 checkpoint.
DR Reactome; R-SSC-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
DR Reactome; R-SSC-8939236; RUNX1 regulates transcription of genes involved in differentiation of HSCs.
DR Reactome; R-SSC-8939902; Regulation of RUNX2 expression and activity.
DR Reactome; R-SSC-8941858; Regulation of RUNX3 expression and activity.
DR Reactome; R-SSC-8948751; Regulation of PTEN stability and activity.
DR Reactome; R-SSC-8951664; Neddylation.
DR Reactome; R-SSC-9020702; Interleukin-1 signaling.
DR Reactome; R-SSC-9755511; KEAP1-NFE2L2 pathway.
DR Reactome; R-SSC-9762114; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2.
DR Reactome; R-SSC-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR ChiTaRS; PSMD9; pig.
DR Proteomes; UP000008227; Chromosome 14.
DR Bgee; ENSSSCG00000036483; Expressed in adult mammalian kidney and 46 other cell types or tissues.
DR ExpressionAtlas; A0A286ZLP7; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0008540; C:proteasome regulatory particle, base subcomplex; IEA:Ensembl.
DR GO; GO:0070682; P:proteasome regulatory particle assembly; IBA:GO_Central.
DR CDD; cd00989; PDZ_metalloprotease; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 6.10.140.1710; -; 1.
DR InterPro; IPR040815; Nas2_N.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR035269; PSMD9.
DR PANTHER; PTHR12651; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9; 1.
DR PANTHER; PTHR12651:SF1; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9; 1.
DR Pfam; PF18265; Nas2_N; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
PE 1: Evidence at protein level;
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A286ZLP7};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT DOMAIN 120..196
FT /note="PDZ"
FT /evidence="ECO:0000259|SMART:SM00228"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 223 AA; 24416 MW; 92FA9ED652EB47EE CRC64;
MSEQEARQSG GSPEASGVTV SDIQALIRRK EEIEAQIKAN YDVLESQKGV GMNEPLVDCE
GYPRSDVDLY QVRTARHNIV CLQNDHKAVM KQVEEALHQL HARDKEKQAQ DLAEAHREAL
SLGLGQSQGL SLPQAFAKVN SISPGSPASI AGLQVDDEIV EFGSVNTQNF QSLQNIGSVV
QHSEGKPLNV TVIRRGEKHQ LRLVPTRWAG KGLLGCNIIP LQR
//
