ID A0A286ZMU2_PIG Unreviewed; 980 AA.
AC A0A286ZMU2;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 3.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Myocardin {ECO:0000313|Ensembl:ENSSSCP00000032776.3};
GN Name=MYOCD {ECO:0000313|Ensembl:ENSSSCP00000032776.3,
GN ECO:0000313|VGNC:VGNC:90536};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000032776.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000032776.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000032776.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000032776.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A286ZMU2; -.
DR Ensembl; ENSSSCT00000046825.3; ENSSSCP00000032776.3; ENSSSCG00000031988.3.
DR VGNC; VGNC:90536; MYOCD.
DR GeneTree; ENSGT00950000182979; -.
DR ChiTaRS; MYOCD; pig.
DR Proteomes; UP000008227; Chromosome 12.
DR Bgee; ENSSSCG00000031988; Expressed in heart left ventricle and 14 other cell types or tissues.
DR ExpressionAtlas; A0A286ZMU2; baseline and differential.
DR GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0035035; F:histone acetyltransferase binding; IEA:Ensembl.
DR GO; GO:0042826; F:histone deacetylase binding; IEA:Ensembl.
DR GO; GO:0070412; F:R-SMAD binding; IEA:Ensembl.
DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IEA:Ensembl.
DR GO; GO:0003713; F:transcription coactivator activity; IEA:Ensembl.
DR GO; GO:0010659; P:cardiac muscle cell apoptotic process; IEA:Ensembl.
DR GO; GO:0060379; P:cardiac muscle cell myoblast differentiation; IEA:Ensembl.
DR GO; GO:0003231; P:cardiac ventricle development; IEA:Ensembl.
DR GO; GO:0043954; P:cellular component maintenance; IEA:Ensembl.
DR GO; GO:0048565; P:digestive tract development; IEA:Ensembl.
DR GO; GO:0097070; P:ductus arteriosus closure; IEA:Ensembl.
DR GO; GO:0048286; P:lung alveolus development; IEA:Ensembl.
DR GO; GO:1900222; P:negative regulation of amyloid-beta clearance; IEA:Ensembl.
DR GO; GO:0010667; P:negative regulation of cardiac muscle cell apoptotic process; IEA:Ensembl.
DR GO; GO:0060354; P:negative regulation of cell adhesion molecule production; IEA:Ensembl.
DR GO; GO:0010832; P:negative regulation of myotube differentiation; IEA:Ensembl.
DR GO; GO:2000587; P:negative regulation of platelet-derived growth factor receptor-beta signaling pathway; IEA:Ensembl.
DR GO; GO:2001015; P:negative regulation of skeletal muscle cell differentiation; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:1904753; P:negative regulation of vascular associated smooth muscle cell migration; IEA:Ensembl.
DR GO; GO:1904706; P:negative regulation of vascular associated smooth muscle cell proliferation; IEA:Ensembl.
DR GO; GO:2000727; P:positive regulation of cardiac muscle cell differentiation; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:1902895; P:positive regulation of miRNA transcription; IEA:Ensembl.
DR GO; GO:0051152; P:positive regulation of smooth muscle cell differentiation; IEA:Ensembl.
DR GO; GO:0045987; P:positive regulation of smooth muscle contraction; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0001560; P:regulation of cell growth by extracellular stimulus; IEA:Ensembl.
DR GO; GO:0045661; P:regulation of myoblast differentiation; IEA:Ensembl.
DR GO; GO:1900239; P:regulation of phenotypic switching; IEA:Ensembl.
DR GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR GO; GO:0045815; P:transcription initiation-coupled chromatin remodeling; IEA:Ensembl.
DR GO; GO:0060157; P:urinary bladder development; IEA:Ensembl.
DR GO; GO:0060065; P:uterus development; IEA:Ensembl.
DR GO; GO:0035886; P:vascular associated smooth muscle cell differentiation; IEA:Ensembl.
DR GO; GO:0001570; P:vasculogenesis; IEA:Ensembl.
DR GO; GO:0055012; P:ventricular cardiac muscle cell differentiation; IEA:Ensembl.
DR Gene3D; 6.10.140.2040; -; 1.
DR Gene3D; 6.10.150.10; -; 1.
DR Gene3D; 1.10.720.30; SAP domain; 1.
DR InterPro; IPR043451; Myocardin-like.
DR InterPro; IPR004018; RPEL_repeat.
DR InterPro; IPR003034; SAP_dom.
DR InterPro; IPR036361; SAP_dom_sf.
DR PANTHER; PTHR22793:SF11; MYOCARDIN; 1.
DR PANTHER; PTHR22793; MYOCARDIN-RELATED TRANSCRIPTION FACTOR-RELATED; 1.
DR Pfam; PF02755; RPEL; 1.
DR Pfam; PF02037; SAP; 1.
DR SMART; SM00707; RPEL; 3.
DR SMART; SM00513; SAP; 1.
DR SUPFAM; SSF68906; SAP domain; 1.
DR PROSITE; PS51073; RPEL; 1.
DR PROSITE; PS50800; SAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT REPEAT 106..131
FT /note="RPEL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00401"
FT DOMAIN 368..402
FT /note="SAP"
FT /evidence="ECO:0000259|PROSITE:PS50800"
FT REGION 154..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 240..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 324..363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 581..601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 660..720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 808..832
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 515..549
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 159..173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..361
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 669..718
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 818..832
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 980 AA; 105254 MW; 4C33EF154E0D40DA CRC64;
MTLLGSEHSL LIRSKFRSVL QLRLQQRRTQ EQLANEGIIP PLRSPPAFHE QRRHLESDKA
ADTLKHKVRN RSDRGNVVKM HILQASSAER PVPAAQMKLK RARLADDLNE KIALRPGPLE
LVEKNILPVD CAVKEAIKGN QVSLSKSADA FAFEEDSSSD GLSPDQTRSE DLPGSAGSPL
DTKAAETPLA GPRGTVQDLT LGSENERNDS APQSGNQSDL GKQGLGPLGS PLPVHAAVKS
KSLSDGKNRH KKPKDPKPKV KKLKYHQYIP PDQKAEKSPP PMDSAYARLL QQQQLFLQLQ
ILSQQQQHRF SYPGIHQAQL KEPNEQMARN PNSSSAPLSS TPLSPAKNSF SGQTGVSSLK
PGPLPSNLDD LKVSELRQQL RIRGLPVSGT KTALMDRLRP FQDCSGNPVP NFGDITTVTF
PVTPSNALPS YQSSPSTSAF YHFGSTSSSP PISPASSDLS VAGSLPDTFN DASPSFGLHP
SPVHACAEES LMSSLNGGSL PPELDGLDSE KDKMLVEKQK VINELTWKLQ QEQRQVEELR
MQLQKQKRGT CPEKKPLPFL AAPIKQEDAG SSCPFAPLPR AVKRQSNSSE EQPAAGDAAR
LRPLGNTHCA ESSGQTNVLS STFLSPQCSP QHSPFGAVKS PQHISLPPSP NNPYFLPASS
GAPGEEHRVS SPVSSQVCTA QTSGAHEGHS PSFSNQPSSL HPPFSGAQAD NSQGAGGNPC
PKSPGVQQKM VGLHSSDKAG PKFSNPSPTF SKSASAVSEI TQPPSYEDAV KQQMTRSQQM
DELLDVLIES GEMPADARED HSCLQKVPKI PGSSRSPTAA LPKPSATFDQ ASSGGQLAFD
HYSNDSDEHL EVLLNSQSPL GKVSEVALLK IGSEEPAFDG MADGFSGKAA EELFNAHEIL
PGPLSPMHTQ FSPSSVDSSG LPLGFTESPW ESMEWLDLTP PSSPGFSSLS TGGPSIFNID
FLDVTDLNLN SPMDLHLQQW
//
