ID A0A286ZN24_PIG Unreviewed; 921 AA.
AC A0A286ZN24;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Inter-alpha-trypsin inhibitor heavy chain 4 {ECO:0000313|Ensembl:ENSSSCP00000033031.2};
GN Name=ITIH4 {ECO:0000313|Ensembl:ENSSSCP00000033031.2,
GN ECO:0000313|VGNC:VGNC:109459};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000033031.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000033031.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000033031.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000033031.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the ITIH family.
CC {ECO:0000256|ARBA:ARBA00010158}.
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DR AlphaFoldDB; A0A286ZN24; -.
DR Ensembl; ENSSSCT00000038206.3; ENSSSCP00000033031.2; ENSSSCG00000011453.5.
DR VGNC; VGNC:109459; ITIH4.
DR GeneTree; ENSGT00940000161039; -.
DR Proteomes; UP000008227; Chromosome 13.
DR Bgee; ENSSSCG00000011453; Expressed in liver and 35 other cell types or tissues.
DR ExpressionAtlas; A0A286ZN24; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0030212; P:hyaluronan metabolic process; IEA:InterPro.
DR CDD; cd01461; vWA_interalpha_trypsin_inhibitor; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR010600; ITI_HC_C.
DR InterPro; IPR013694; VIT.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10338; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER; 1.
DR PANTHER; PTHR10338:SF119; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H4; 1.
DR Pfam; PF06668; ITI_HC_C; 1.
DR Pfam; PF08487; VIT; 1.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00609; VIT; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51468; VIT; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 1: Evidence at protein level;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A286ZN24};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 11..140
FT /note="VIT"
FT /evidence="ECO:0000259|PROSITE:PS51468"
FT DOMAIN 266..449
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 587..642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..634
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 921 AA; 102118 MW; 66868AB4A0E3A84C CRC64;
AQTPLPTPYL WNNQTIPPSL VQNDINIYSL TVDSKVSSRF AHTVVTSRVV NKGSAVQEAT
FQMELPKKAF ITNFSMIIDG VTYPGNIKEK AAAQEQYSAA VARGESAGLV RATGRKTEQF
QVAVSVAPAA KVTFELVYEE LLARHLGVYE LLLKIQPQQL VKHLQMDIHI FEPQGISFLE
TESTFMTNEL AEALTISQNK TKAHIRFKPT LSQQQKSPEQ QETVLDGNFI VRYDVNRTVT
GGSIQIENGY FVHYFAPEGL SAIPKNVVFV IDTSGSMRGR KIQQTREALI KILGDLGSRD
QFNLVSFSGE ATQWKKGLLP ASAENVEEAK SYAAEIHAQG GTNINDAMLM AVQLLERANR
EELLPARSVT LIILLTDGDP TVGETNPSKI QKNVREAIDG QHSLFCLGFG FDVSYAFLEK
MALENGGLAR RIYEDSDSAL QLEDFYQEVA NPLLRLVAFE YPSNAVEAVT QDNFRLFFKG
SELVVAGKLR DQSPDVLSAK VRGQLHMENV TFVMESRVAE QEAEFLSPKY IFHSFMERLW
AYLTIQQLLA QTVSASDAEK KALEARALSL SLNYSFVTPL TSMVITKPEG QEQSQVAEKP
VENGNRQGNT HSGHSSFQFH SVGDRTSRLT GGSSVDPVFS HRRGWKGQAQ GFEKMSYLPP
RLGPPGPLQP TRFSHPFSRI TLDRVLPEVL SVPDETSHDM DSRIIGTARP ETIPVVPARI
QAPSVILPLP GQSVDQLCVD LKHSQGPVKL LSDPGQGVEV TGHYEREKAR FSWIEVTFKH
PPLQVRASLE HIVVIRNRQS SAYKWKETLY SVMPGLKITM DKAGLLLLSS PNRVTIGLLS
WDGPGKGLRL LLRDTDHFSS QISGTFGQFY QDVVWGPPAA ADDSKRTVTV QGHDHSATRE
LKLDYQEGSP GKEISCWTVV L
//