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Database: UniProt
Entry: A0A286ZN24_PIG
LinkDB: A0A286ZN24_PIG
Original site: A0A286ZN24_PIG 
ID   A0A286ZN24_PIG          Unreviewed;       921 AA.
AC   A0A286ZN24;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2019, sequence version 2.
DT   24-JAN-2024, entry version 28.
DE   SubName: Full=Inter-alpha-trypsin inhibitor heavy chain 4 {ECO:0000313|Ensembl:ENSSSCP00000033031.2};
GN   Name=ITIH4 {ECO:0000313|Ensembl:ENSSSCP00000033031.2,
GN   ECO:0000313|VGNC:VGNC:109459};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000033031.2, ECO:0000313|Proteomes:UP000008227};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000033031.2, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000033031.2,
RC   ECO:0000313|Proteomes:UP000008227};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSSCP00000033031.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the ITIH family.
CC       {ECO:0000256|ARBA:ARBA00010158}.
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DR   AlphaFoldDB; A0A286ZN24; -.
DR   Ensembl; ENSSSCT00000038206.3; ENSSSCP00000033031.2; ENSSSCG00000011453.5.
DR   VGNC; VGNC:109459; ITIH4.
DR   GeneTree; ENSGT00940000161039; -.
DR   Proteomes; UP000008227; Chromosome 13.
DR   Bgee; ENSSSCG00000011453; Expressed in liver and 35 other cell types or tissues.
DR   ExpressionAtlas; A0A286ZN24; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0030212; P:hyaluronan metabolic process; IEA:InterPro.
DR   CDD; cd01461; vWA_interalpha_trypsin_inhibitor; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR010600; ITI_HC_C.
DR   InterPro; IPR013694; VIT.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10338; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER; 1.
DR   PANTHER; PTHR10338:SF119; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H4; 1.
DR   Pfam; PF06668; ITI_HC_C; 1.
DR   Pfam; PF08487; VIT; 1.
DR   Pfam; PF00092; VWA; 1.
DR   SMART; SM00609; VIT; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS51468; VIT; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   1: Evidence at protein level;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:A0A286ZN24};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW   Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          11..140
FT                   /note="VIT"
FT                   /evidence="ECO:0000259|PROSITE:PS51468"
FT   DOMAIN          266..449
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          587..642
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        587..634
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   921 AA;  102118 MW;  66868AB4A0E3A84C CRC64;
     AQTPLPTPYL WNNQTIPPSL VQNDINIYSL TVDSKVSSRF AHTVVTSRVV NKGSAVQEAT
     FQMELPKKAF ITNFSMIIDG VTYPGNIKEK AAAQEQYSAA VARGESAGLV RATGRKTEQF
     QVAVSVAPAA KVTFELVYEE LLARHLGVYE LLLKIQPQQL VKHLQMDIHI FEPQGISFLE
     TESTFMTNEL AEALTISQNK TKAHIRFKPT LSQQQKSPEQ QETVLDGNFI VRYDVNRTVT
     GGSIQIENGY FVHYFAPEGL SAIPKNVVFV IDTSGSMRGR KIQQTREALI KILGDLGSRD
     QFNLVSFSGE ATQWKKGLLP ASAENVEEAK SYAAEIHAQG GTNINDAMLM AVQLLERANR
     EELLPARSVT LIILLTDGDP TVGETNPSKI QKNVREAIDG QHSLFCLGFG FDVSYAFLEK
     MALENGGLAR RIYEDSDSAL QLEDFYQEVA NPLLRLVAFE YPSNAVEAVT QDNFRLFFKG
     SELVVAGKLR DQSPDVLSAK VRGQLHMENV TFVMESRVAE QEAEFLSPKY IFHSFMERLW
     AYLTIQQLLA QTVSASDAEK KALEARALSL SLNYSFVTPL TSMVITKPEG QEQSQVAEKP
     VENGNRQGNT HSGHSSFQFH SVGDRTSRLT GGSSVDPVFS HRRGWKGQAQ GFEKMSYLPP
     RLGPPGPLQP TRFSHPFSRI TLDRVLPEVL SVPDETSHDM DSRIIGTARP ETIPVVPARI
     QAPSVILPLP GQSVDQLCVD LKHSQGPVKL LSDPGQGVEV TGHYEREKAR FSWIEVTFKH
     PPLQVRASLE HIVVIRNRQS SAYKWKETLY SVMPGLKITM DKAGLLLLSS PNRVTIGLLS
     WDGPGKGLRL LLRDTDHFSS QISGTFGQFY QDVVWGPPAA ADDSKRTVTV QGHDHSATRE
     LKLDYQEGSP GKEISCWTVV L
//
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