ID A0A286ZPX1_PIG Unreviewed; 191 AA.
AC A0A286ZPX1; A0A4X1UBB8;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Potassium voltage-gated channel subfamily E member 4 {ECO:0000313|EMBL:HDC32459.1};
DE SubName: Full=Potassium voltage-gated channel subfamily E regulatory subunit 4 {ECO:0000313|Ensembl:ENSSSCP00000033659.1};
GN Name=KCNE4 {ECO:0000313|Ensembl:ENSSSCP00000033659.1,
GN ECO:0000313|VGNC:VGNC:96387};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000033659.1, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000033659.1, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000033659.1,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HDC32459.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000033659.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the potassium channel KCNE family.
CC {ECO:0000256|ARBA:ARBA00005688}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DQIR01276981; HDC32459.1; -; Transcribed_RNA.
DR EMBL; DQIR01289520; HDC44998.1; -; Transcribed_RNA.
DR RefSeq; XP_005672306.1; XM_005672249.2.
DR STRING; 9823.ENSSSCP00000033659; -.
DR PaxDb; 9823-ENSSSCP00000017185; -.
DR Ensembl; ENSSSCT00000047314.3; ENSSSCP00000033659.1; ENSSSCG00000038149.3.
DR Ensembl; ENSSSCT00005004627.1; ENSSSCP00005002681.1; ENSSSCG00005003110.1.
DR GeneID; 397167; -.
DR KEGG; ssc:397167; -.
DR CTD; 23704; -.
DR VGNC; VGNC:96387; KCNE4.
DR eggNOG; ENOG502RZ36; Eukaryota.
DR GeneTree; ENSGT00390000013776; -.
DR OMA; SPDVHFT; -.
DR OrthoDB; 5355043at2759; -.
DR Reactome; R-SSC-5576890; Phase 3 - rapid repolarisation.
DR Proteomes; UP000008227; Chromosome 15.
DR Bgee; ENSSSCG00000038149; Expressed in stomach and 27 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0015459; F:potassium channel regulator activity; IBA:GO_Central.
DR GO; GO:0044325; F:transmembrane transporter binding; IBA:GO_Central.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR GO; GO:0086011; P:membrane repolarization during action potential; IBA:GO_Central.
DR GO; GO:0098915; P:membrane repolarization during ventricular cardiac muscle cell action potential; IEA:GOC.
DR GO; GO:0097623; P:potassium ion export across plasma membrane; IBA:GO_Central.
DR GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IBA:GO_Central.
DR GO; GO:0060307; P:regulation of ventricular cardiac muscle cell membrane repolarization; IBA:GO_Central.
DR GO; GO:0086005; P:ventricular cardiac muscle cell action potential; IBA:GO_Central.
DR InterPro; IPR000369; K_chnl_KCNE.
DR PANTHER; PTHR15282; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY E MEMBER 1, 3; 1.
DR PANTHER; PTHR15282:SF9; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY E MEMBER 4; 1.
DR Pfam; PF02060; ISK_Channel; 1.
DR PRINTS; PR00168; KCNECHANNEL.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 57..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 29..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 145..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..191
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 191 AA; 20870 MW; CB5897D1E016CFBC CRC64;
MIEEFRTNLP ALDPGCVSRA SMLKMEPLNS THTSTAAPSG PLESHVQSSG SSNGNEYFYV
LVVMSFYGIF LIGIMLGYMK SKRWEKKSSL LLLYKDEERL WGEAMKPLPM VSGLRAVQVP
MVLNVLQESV APALSCTLCS MEGDSVSSES SSPDVHLTIQ EEGADDELEE TSETPLNESS
EGSSENIHQN S
//
