ID A0A286ZQM3_PIG Unreviewed; 430 AA.
AC A0A286ZQM3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Cell adhesion molecule 3 {ECO:0000313|EMBL:HDA68965.1, ECO:0000313|Ensembl:ENSSSCP00000033904.1};
GN Name=CADM3 {ECO:0000313|Ensembl:ENSSSCP00000033904.1,
GN ECO:0000313|VGNC:VGNC:86135};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000033904.1, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000033904.1, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000033904.1,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HDA68965.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000033904.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the nectin family.
CC {ECO:0000256|ARBA:ARBA00007810}.
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DR EMBL; DQIR01113489; HDA68965.1; -; Transcribed_RNA.
DR EMBL; DQIR01267058; HDC22536.1; -; Transcribed_RNA.
DR STRING; 9823.ENSSSCP00000033904; -.
DR Ensembl; ENSSSCT00000042275.3; ENSSSCP00000033904.1; ENSSSCG00000006415.5.
DR VGNC; VGNC:86135; CADM3.
DR GeneTree; ENSGT00940000159779; -.
DR OrthoDB; 3039994at2759; -.
DR Reactome; R-SSC-418990; Adherens junctions interactions.
DR Reactome; R-SSC-420597; Nectin/Necl trans heterodimerization.
DR Proteomes; UP000008227; Chromosome 4.
DR Bgee; ENSSSCG00000006415; Expressed in prefrontal cortex and 33 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IBA:GO_Central.
DR CDD; cd07705; IgI_2_Necl-1; 1.
DR CDD; cd05882; IgV_1_Necl-1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR003585; Neurexin-like.
DR PANTHER; PTHR45889:SF5; CELL ADHESION MOLECULE 3; 1.
DR PANTHER; PTHR45889; IG-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00294; 4.1m; 1.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 1: Evidence at protein level;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A286ZQM3};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..430
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041060264"
FT TRANSMEM 361..388
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 55..144
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 162..260
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 265..347
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 399..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 430 AA; 46859 MW; 5BBADD30CCC7736A CRC64;
MGAPSALPLL LLFACCWAPG GANLSQDGYW QEQNLELGTL ASLDEAISST VWSSPDMLAS
QDSQPWTSDE TVVAGGTVVL KCQVKEHEDS SLQWSNPAQQ TLYFGEKRAL RDNRIQLVRS
TPHELSISIS NVALADEGEY TCSIFTMPVR TAKSLVTVLG IPQKPIITGY KSSLREKDTT
TLNCQSSGSK PAAQLTWRKG DQELHGEPTR VQEDPNGKTF TVSSSVTFQV TQEDDGADIV
CSVNHESLKG ADRSTSQRIE VLYKPTAKIR PDPPHPREGQ KLLLHCEGRG NPVPQQYLWE
KEGSVPPLKM TQDSALIFPF LNKSDSGTYG CTATSNMGSY KAYYTLNVND PSPVPSSSST
YHAIIGGIVA FIVFLLLILL IFLGHYLIRH KGTYLTHEAK GSDDAPDADT AIINAEGGQS
GGDDKKEYFI
//
