ID A0A286ZQZ3_PIG Unreviewed; 268 AA.
AC A0A286ZQZ3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=COP9 signalosome subunit 7A {ECO:0000313|Ensembl:ENSSSCP00000033891.1};
GN Name=COPS7A {ECO:0000313|Ensembl:ENSSSCP00000033891.1,
GN ECO:0000313|VGNC:VGNC:86902};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000033891.1, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000033891.1, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000033891.1,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000033891.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the COP9 signalosome complex (CSN), a complex
CC involved in various cellular and developmental processes. The CSN
CC complex is an essential regulator of the ubiquitin (Ubl) conjugation
CC pathway by mediating the deneddylation of the cullin subunits of SCF-
CC type E3 ligase complexes, leading to decrease the Ubl ligase activity
CC of SCF-type complexes such as SCF, CSA or DDB2. The complex is also
CC involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA,
CC ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD
CC kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and
CC protects degradation by the Ubl system, respectively.
CC {ECO:0000256|ARBA:ARBA00025037}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
CC {ECO:0000256|ARBA:ARBA00008482}.
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DR AlphaFoldDB; A0A286ZQZ3; -.
DR Ensembl; ENSSSCT00000049774.3; ENSSSCP00000033891.1; ENSSSCG00000000691.5.
DR VGNC; VGNC:86902; COPS7A.
DR GeneTree; ENSGT00940000159873; -.
DR Proteomes; UP000008227; Chromosome 5.
DR Bgee; ENSSSCG00000000691; Expressed in longissimus lumborum muscle and 45 other cell types or tissues.
DR ExpressionAtlas; A0A286ZQZ3; baseline and differential.
DR GO; GO:0008180; C:COP9 signalosome; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0010387; P:COP9 signalosome assembly; IEA:InterPro.
DR InterPro; IPR045237; COPS7/eIF3m.
DR InterPro; IPR041481; CSN7_helixI.
DR InterPro; IPR000717; PCI_dom.
DR PANTHER; PTHR15350; COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17; 1.
DR PANTHER; PTHR15350:SF7; COP9 SIGNALOSOME COMPLEX SUBUNIT 7A; 1.
DR Pfam; PF18392; CSN7a_helixI; 1.
DR Pfam; PF01399; PCI; 1.
DR SMART; SM00088; PINT; 1.
DR PROSITE; PS50250; PCI; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A286ZQZ3};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT DOMAIN 1..138
FT /note="PCI"
FT /evidence="ECO:0000259|PROSITE:PS50250"
FT REGION 208..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 178..205
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 268 AA; 29498 MW; 43255A3DDF8F0299 CRC64;
MSAEVKVTGQ NQEQFLLLAK SAKGAALATL IHQLAESDFA STFRLLTVFA YGTYADYLAE
ARNLPPLTEA QKNKLRHLSV VTLAAKVKCI PYAVLLEALA LRNVRQLEDL VIEAVYADVL
RGSLDQRNQR LEVDYSIGRD IQRQDLSAIA RTLQEWCVGC EVVLSGIEEQ VSRANQHKEQ
QLGLKQQIES EVANLKKTIK VTTAAAAAAT SQDPEQHLTE LREPAPGTNQ RQPSKKASKG
KGHCVDPFSH CVDPLTLALH LQQPVKQA
//
