ID A0A286ZST8_PIG Unreviewed; 478 AA.
AC A0A286ZST8;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=DENN domain containing 2D {ECO:0000313|Ensembl:ENSSSCP00000034706.1};
DE SubName: Full=DENN domain-containing protein 2D isoform a {ECO:0000313|EMBL:HDC48127.1};
GN Name=DENND2D {ECO:0000313|Ensembl:ENSSSCP00000034706.1,
GN ECO:0000313|VGNC:VGNC:87249};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000034706.1, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000034706.1, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000034706.1,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HDC48127.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000034706.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DQIR01292649; HDC48127.1; -; Transcribed_RNA.
DR STRING; 9823.ENSSSCP00000034706; -.
DR PaxDb; 9823-ENSSSCP00000007250; -.
DR Ensembl; ENSSSCT00000057937.3; ENSSSCP00000034706.1; ENSSSCG00000025704.4.
DR VGNC; VGNC:87249; DENND2D.
DR eggNOG; KOG3569; Eukaryota.
DR GeneTree; ENSGT00950000182931; -.
DR OrthoDB; 5398783at2759; -.
DR Reactome; R-SSC-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR Proteomes; UP000008227; Chromosome 4.
DR Bgee; ENSSSCG00000025704; Expressed in blood and 37 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR15288; DENN DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR15288:SF2; DENN DOMAIN-CONTAINING PROTEIN 2D; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00800; uDENN; 1.
DR PROSITE; PS50211; DENN; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT DOMAIN 62..452
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
SQ SEQUENCE 478 AA; 54461 MW; 95914FEE5294EB70 CRC64;
MPYAPQKMDR QAVARLLGRF GQWLPRHGAG SPQDHLGEGV KEPERTQEHC LPNFAGGQHF
FEYLLVVSLK KKHSGPDYEP TITYQFPKRE NLLRGQQEEE ERLLGAIPLF CFPDGNEWAP
LTEYPRETFS FVLTNVDGSR KIGYCRRLLP AGRGPRLPEV YCIISCIGCF GLFSKILDEV
EKRHQISVAV IYPFMQGLRE AAFPAPGKTV TLKSFIPDSG TEFISLTRPL DSHLEHVDFS
SLLHCLSFEQ ILQIFASAVL ERRIIFLAEG LSTLSQCIHA AAALLYPFSW AHTYIPVVPE
SLLDTVCCPT PFMVGVQMRF REKVMESPME EVLLVDLCEG TFLMSVGDEK HILPPKLQDD
ILDSLGHKIK ELQTSEQINE HVSGPFVQFF VKTVGHYASY IKREANGQGH FQERAFYKAL
PSKANRRFVK KFVKTQLFSL FIQEAEKSKN PPAGYFQKKI LEYEEQKKQK KSKEKTVK
//
