ID   A0A286ZU34_PIG          Unreviewed;       741 AA.
AC   A0A286ZU34;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2022, sequence version 3.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=Terpene cyclase/mutase family member {ECO:0000256|RuleBase:RU362003};
DE            EC=5.4.99.- {ECO:0000256|RuleBase:RU362003};
GN   Name=LSS {ECO:0000313|Ensembl:ENSSSCP00000035138.3,
GN   ECO:0000313|VGNC:VGNC:96406};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000035138.3, ECO:0000313|Proteomes:UP000008227};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000035138.3}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000035138.3};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSSCP00000035138.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC       {ECO:0000256|ARBA:ARBA00009755, ECO:0000256|RuleBase:RU362003}.
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DR   AlphaFoldDB; A0A286ZU34; -.
DR   STRING; 9823.ENSSSCP00000035138; -.
DR   PaxDb; 9823-ENSSSCP00000019927; -.
DR   Ensembl; ENSSSCT00000042882.3; ENSSSCP00000035138.3; ENSSSCG00000021418.4.
DR   VGNC; VGNC:96406; LSS.
DR   GeneTree; ENSGT00390000011570; -.
DR   InParanoid; A0A286ZU34; -.
DR   Reactome; R-SSC-191273; Cholesterol biosynthesis.
DR   Proteomes; UP000008227; Unplaced.
DR   Bgee; ENSSSCG00000021418; Expressed in ovary and 44 other cell types or tissues.
DR   ExpressionAtlas; A0A286ZU34; baseline and differential.
DR   GO; GO:0005811; C:lipid droplet; IBA:GO_Central.
DR   GO; GO:0000250; F:lanosterol synthase activity; IBA:GO_Central.
DR   GO; GO:0006695; P:cholesterol biosynthetic process; IBA:GO_Central.
DR   GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR   CDD; cd02892; SQCY_1; 1.
DR   Gene3D; 1.50.10.20; -; 2.
DR   Gene3D; 6.20.120.20; -; 1.
DR   InterPro; IPR032696; SQ_cyclase_C.
DR   InterPro; IPR032697; SQ_cyclase_N.
DR   InterPro; IPR018333; Squalene_cyclase.
DR   InterPro; IPR002365; Terpene_synthase_CS.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   NCBIfam; TIGR01787; squalene_cyclas; 1.
DR   PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR   PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR   Pfam; PF13243; SQHop_cyclase_C; 1.
DR   Pfam; PF13249; SQHop_cyclase_N; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
DR   PROSITE; PS01074; TERPENE_SYNTHASES; 1.
PE   1: Evidence at protein level;
KW   Isomerase {ECO:0000256|RuleBase:RU362003};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:A0A286ZU34};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          81..321
FT                   /note="Squalene cyclase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13249"
FT   DOMAIN          567..728
FT                   /note="Squalene cyclase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13243"
SQ   SEQUENCE   741 AA;  83819 MW;  D8EAF40834C4B20F CRC64;
     CLRRRRGPVK MEPATDLSRW RLSNEKGRQR WTYLQEEESP SREQSGLEAH LLGLDTRSYF
     KDLPKAHTAR EGALNGMTFY TGLQAEDGHW AGDYGGPLFL TPGLLIVCYT ARIPLPAGYR
     EEMIRFLWSA QLPDGGWGLH IEDKSTVFGT VLNYVSLRIL GVGPDDPNLV RARNVLHAKG
     GALYTPSWGK FWLAVLNVYS WEGLNTLLPE MWLLPTWMPM HPSKLWCHCR QVYLPMAYCY
     STRLSTEEDP LVQSLRQEIY VEDYGLIDWP AHRNSVAADD LYSPHSWLLN ALYAVLNFYE
     RHHSTSLRQR ATQELYEHIA ADDHFSKCIS IGPISKTINM LVRWYVDGPA SSVFQEHVSR
     IPDYLWLGID GMKMQVRAVG PQLLAGAQHR PEFLTCLQKA HEYLRVSQVP DNYPDHQKYY
     RQMSKGGFPF STLDCGWIVA DCTAEALKSV LLLQENCPCI TQHIPQERLF DAVAVLLSMR
     NADGGFATYE TKRGGHLLEL LNPSEVFGDI MIDYTYVECT SSVMQALKEF HHQFPDHRAG
     EISLSVTLSV PLIPVAAASD AGWCPRETLE QGLDFCRRKQ RADGSWEGSW GVCFTYGTWF
     GLEAFACMGH TYRDGAACTE VSQACDFLLS RQMEDGGWGE DFESCRQRRY VQNARSQIHN
     TCWALMGLLA VRHPDVAALE RAVSFLLGKQ LPNGDWPQDS SAGVFNKTCA ITYTSYSNVF
     PIWALGRFSH LHPESALAGC P
//