ID A0A286ZVH7_PIG Unreviewed; 464 AA.
AC A0A286ZVH7;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Tumor necrosis factor receptor superfamily member 1A {ECO:0000256|ARBA:ARBA00016302};
DE AltName: Full=Tumor necrosis factor receptor 1 {ECO:0000256|ARBA:ARBA00031785};
DE AltName: Full=Tumor necrosis factor receptor type I {ECO:0000256|ARBA:ARBA00030825};
DE AltName: Full=p55 {ECO:0000256|ARBA:ARBA00031535};
DE AltName: Full=p60 {ECO:0000256|ARBA:ARBA00031548};
GN Name=TNFRSF1A {ECO:0000313|Ensembl:ENSSSCP00000035606.2,
GN ECO:0000313|VGNC:VGNC:109417};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000035606.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000035606.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000035606.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000035606.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004614}; Single-pass
CC type I membrane protein {ECO:0000256|ARBA:ARBA00004614}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR AlphaFoldDB; A0A286ZVH7; -.
DR SMR; A0A286ZVH7; -.
DR Ensembl; ENSSSCT00000052544.3; ENSSSCP00000035606.2; ENSSSCG00000000708.6.
DR VGNC; VGNC:109417; TNFRSF1A.
DR GeneTree; ENSGT00940000159540; -.
DR InParanoid; A0A286ZVH7; -.
DR Reactome; R-SSC-5357786; TNFR1-induced proapoptotic signaling.
DR Reactome; R-SSC-5357905; Regulation of TNFR1 signaling.
DR Reactome; R-SSC-5357956; TNFR1-induced NF-kappa-B signaling pathway.
DR Reactome; R-SSC-5626978; TNFR1-mediated ceramide production.
DR Reactome; R-SSC-5669034; TNFs bind their physiological receptors.
DR Reactome; R-SSC-75893; TNF signaling.
DR Proteomes; UP000008227; Chromosome 5.
DR Bgee; ENSSSCG00000000708; Expressed in blood and 42 other cell types or tissues.
DR ExpressionAtlas; A0A286ZVH7; baseline and differential.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045121; C:membrane raft; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR GO; GO:0043120; F:tumor necrosis factor binding; IBA:GO_Central.
DR GO; GO:0005031; F:tumor necrosis factor receptor activity; IBA:GO_Central.
DR GO; GO:0003176; P:aortic valve development; IEA:Ensembl.
DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR GO; GO:0042742; P:defense response to bacterium; IEA:Ensembl.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IEA:Ensembl.
DR GO; GO:0010614; P:negative regulation of cardiac muscle hypertrophy; IEA:Ensembl.
DR GO; GO:0003332; P:negative regulation of extracellular matrix constituent secretion; IEA:Ensembl.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0034250; P:positive regulation of amide metabolic process; IEA:Ensembl.
DR GO; GO:1902339; P:positive regulation of apoptotic process involved in morphogenesis; IEA:Ensembl.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:1900119; P:positive regulation of execution phase of apoptosis; IEA:Ensembl.
DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0045834; P:positive regulation of lipid metabolic process; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
DR GO; GO:0006693; P:prostaglandin metabolic process; IEA:InterPro.
DR GO; GO:0072659; P:protein localization to plasma membrane; IEA:Ensembl.
DR GO; GO:0003177; P:pulmonary valve development; IEA:Ensembl.
DR GO; GO:1903140; P:regulation of establishment of endothelial barrier; IEA:Ensembl.
DR GO; GO:1905038; P:regulation of membrane lipid metabolic process; IEA:Ensembl.
DR GO; GO:0010803; P:regulation of tumor necrosis factor-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:Ensembl.
DR CDD; cd08313; Death_TNFR1; 1.
DR CDD; cd10576; TNFRSF1A; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR020419; TNFR_1A.
DR InterPro; IPR033994; TNFRSF1A_death.
DR InterPro; IPR033993; TNFRSF1A_N.
DR PANTHER; PTHR46861; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1A; 1.
DR PANTHER; PTHR46861:SF1; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1A; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF00020; TNFR_c6; 2.
DR PRINTS; PR01918; TNFACTORR1A.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00208; TNFR; 4.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF57586; TNF receptor-like; 3.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS00652; TNFR_NGFR_1; 2.
DR PROSITE; PS50050; TNFR_NGFR_2; 2.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00206}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 214..236
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 86..128
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 86..128
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT REPEAT 129..169
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 129..169
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT DOMAIN 365..450
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT DISULFID 87..102
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 464 AA; 51072 MW; 23B7F75600B4A79A CRC64;
SSLTSTPGLL PLTPSQVLRA LLVDVYPAGV HGLVLHPGDR EKRESLCPQG KYSHPQNRSI
CCTKCHKGTY LHNDCLGPGL DTDCRECDNG TFTASENHLT QCLSCSKCRS EMSQVEISPC
TVDRDTVCGC RKNQYRKYWS ETLFQCLNCS LCPNGTVQLP CLEKQDTICN CHSGFFLRDK
ECVSCVNCKN ADCKNLCPAT SETRNDFQDT GTTVLLPLVI FFGLCLAFFL FVGLACRYQR
WKPKLYSISK WAVPSVFQGE PEPLATAPSF GPITTFSPIP SFSPTTTFSP VPSFSPISSP
TFTPCDWSNI KVTSPPKEIA PPPQGAGPIL PMPPASTPVP TPLPKWGGSA HSAHSAPAQL
ADADPATLYA VVDGVPPTRW KEFVRRLGLS EHEIERLELQ NGRCLREAQY SMLAEWRRRT
SRREATLELL GSVLRDMDLL GCLEDIEEAL RGPARLAPAP HLLR
//
