ID A0A286ZXA0_PIG Unreviewed; 250 AA.
AC A0A286ZXA0;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Insulin like growth factor binding protein 7 {ECO:0000313|Ensembl:ENSSSCP00000036250.2};
DE SubName: Full=Insulin-like growth factor-binding protein 7 isoform 2 {ECO:0000313|EMBL:HDA97028.1};
GN Name=IGFBP7 {ECO:0000313|Ensembl:ENSSSCP00000036250.2,
GN ECO:0000313|VGNC:VGNC:89060};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000036250.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000036250.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000036250.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HDA97028.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000036250.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DQIR01141552; HDA97028.1; -; Transcribed_RNA.
DR Ensembl; ENSSSCT00000040094.3; ENSSSCP00000036250.2; ENSSSCG00000008913.5.
DR VGNC; VGNC:89060; IGFBP7.
DR eggNOG; ENOG502RACD; Eukaryota.
DR GeneTree; ENSGT00530000063555; -.
DR Proteomes; UP000008227; Chromosome 8.
DR Bgee; ENSSSCG00000008913; Expressed in ovary and 42 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005520; F:insulin-like growth factor binding; IEA:InterPro.
DR GO; GO:0001558; P:regulation of cell growth; IEA:InterPro.
DR CDD; cd00104; KAZAL_FS; 1.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 4.10.40.20; -; 1.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR011390; IGFBP_rP_mac25.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR PANTHER; PTHR14186; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR14186:SF15; INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 7; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR SMART; SM00121; IB; 1.
DR SMART; SM00280; KAZAL; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 1: Evidence at protein level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A286ZXA0};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..250
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041162344"
FT DOMAIN 28..114
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 105..158
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 160..195
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 250 AA; 25816 MW; 432760720414441B CRC64;
MERPPLPALL LGAAGLLLLL LPLSSSSSSD ACGPCEPATC PPLPPRGCPL GETRDACGCC
PVCARGEGEP CGGGGAGRGH CAPGMECVKS RKRRKGKAGA AAGGPGVSGV CVCKSRYPVC
GSDGVTYPSG CQLRAASLRA ESRGEKAVTQ VSKGTCEQGP SIVTPPKDIW NVTGAQVYLS
CEVIGIPTPA LIWNKVQRGH YGVQRTELLP GDRDNLAIQT RGGPEKHEVT GWVLVKVLSC
KPAEYISLRS
//
