ID   A0A286ZXZ1_PIG          Unreviewed;       709 AA.
AC   A0A286ZXZ1;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2019, sequence version 2.
DT   27-MAR-2024, entry version 36.
DE   SubName: Full=EMAP like 2 {ECO:0000313|Ensembl:ENSSSCP00000036512.2};
GN   Name=EML2 {ECO:0000313|Ensembl:ENSSSCP00000036512.2,
GN   ECO:0000313|VGNC:VGNC:87683};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000036512.2, ECO:0000313|Proteomes:UP000008227};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000036512.2, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000036512.2,
RC   ECO:0000313|Proteomes:UP000008227};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSSCP00000036512.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000256|ARBA:ARBA00004245}.
CC   -!- SIMILARITY: Belongs to the WD repeat EMAP family.
CC       {ECO:0000256|ARBA:ARBA00006489}.
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DR   AlphaFoldDB; A0A286ZXZ1; -.
DR   Ensembl; ENSSSCT00000063505.2; ENSSSCP00000036512.2; ENSSSCG00000038229.3.
DR   VGNC; VGNC:87683; EML2.
DR   GeneTree; ENSGT00940000153887; -.
DR   Proteomes; UP000008227; Chromosome 6.
DR   Bgee; ENSSSCG00000038229; Expressed in hypothalamus and 43 other cell types or tissues.
DR   ExpressionAtlas; A0A286ZXZ1; baseline and differential.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR005108; HELP.
DR   InterPro; IPR011041; Quinoprot_gluc/sorb_DH.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR13720:SF50; ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 2; 1.
DR   PANTHER; PTHR13720; WD-40 REPEAT PROTEIN; 1.
DR   Pfam; PF03451; HELP; 1.
DR   Pfam; PF00400; WD40; 6.
DR   SMART; SM00320; WD40; 11.
DR   SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR   SUPFAM; SSF50952; Soluble quinoprotein glucose dehydrogenase; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|PeptideAtlas:A0A286ZXZ1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW   WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT   DOMAIN          82..152
FT                   /note="HELP"
FT                   /evidence="ECO:0000259|Pfam:PF03451"
FT   REPEAT          350..381
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          433..474
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          516..557
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          562..603
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          674..709
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ   SEQUENCE   709 AA;  76919 MW;  2BA3151A4E6EFA1B CRC64;
     MGPSHQDAPQ WRGTPTASGR LCHFPILPQK GGDLRAQCPP LLVTRAPRLS APRGPPPAAA
     MSSFGAGKTK EVIFSLEEGA VKMFLRGRPV PMLIPDELAP TYSLDTRSEL PSCRLKLDWV
     YGYRGRDCRA NLYLLPTGEI VYFVASVAVL YSVEEQRQRH YLGHNDDIKC LAVHPDMVTI
     ATGQVAGTTK EGKPLPPHVR IWDSVSLSTL HVLGLGVFDR AVCCVGFSKS NGGNLLCAVD
     ESNDHMLSVW DWAKETKTVD AKCSNEAVLV ATFHPTDPSV LITCGKSHIY FWSLEGGSLS
     KRQGLFEKHE KPKYVLCVTF LEGGDVVTGD SGGNLYVWGK GGNRITQAVL GAHDGGVFGL
     CALRDGTLVS GGGRDRRVVV WGSDYSKLQE VEVPEDFGPV RTVAEGRGDT LYVGTTRNSI
     LQGSVHTGFS LLVQGHVEEL WGLATHPSRA QFVTCGQDKL VHLWSAESHQ PLWSRIIEDP
     ARSAGFHPTG SVLAVGTVTG RWLLLDTETH DLVAIHTDGN EQISVVSFSP DGAYLAVGSH
     DNLVYVYTVD QGGRKVSRLG KCSGHSSFIT HLDWAQDSSC FVTNSGDYEI LYWDPTTCKQ
     ITTADAVRNV EWATATCILG FGVFGIWSEG ADGTDINAVA RSHDGKLLAS ADDFGKVHLF
     SYPCCQPRAL SHKYGGHSSH VTNVAFLWDD SMALTTGGKD TSVLQWRVV
//