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Database: UniProt
Entry: A0A287A263_PIG
LinkDB: A0A287A263_PIG
Original site: A0A287A263_PIG 
ID   A0A287A263_PIG          Unreviewed;      1868 AA.
AC   A0A287A263;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   31-JUL-2019, entry version 16.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSSCP00000038025};
GN   Name=DICER1 {ECO:0000313|Ensembl:ENSSSCP00000038025};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
OC   Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000038025, ECO:0000313|Proteomes:UP000008227};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000038025, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000038025,
RC   ECO:0000313|Proteomes:UP000008227};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSSCP00000038025}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2017) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the helicase family. Dicer subfamily.
CC       {ECO:0000256|PROSITE-ProRule:PRU00657}.
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DR   EMBL; AEMK02000061; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSSSCT00000039889; ENSSSCP00000038025; ENSSSCG00000028225.
DR   GeneTree; ENSGT00940000156287; -.
DR   OMA; FLNDCNI; -.
DR   Proteomes; UP000008227; Chromosome 7.
DR   ExpressionAtlas; A0A287A263; baseline.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004525; F:ribonuclease III activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   CDD; cd00048; DSRM; 1.
DR   CDD; cd00593; RIBOc; 2.
DR   Gene3D; 1.10.1520.10; -; 1.
DR   Gene3D; 3.30.160.380; -; 1.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR038248; Dicer_dimer_sf.
DR   InterPro; IPR005034; Dicer_dimerisation_dom.
DR   InterPro; IPR014720; dsRBD_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR003100; PAZ_dom.
DR   InterPro; IPR036085; PAZ_dom_sf.
DR   InterPro; IPR000999; RNase_III_dom.
DR   InterPro; IPR036389; RNase_III_sf.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF03368; Dicer_dimer; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF02170; PAZ; 1.
DR   Pfam; PF00636; Ribonuclease_3; 2.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00358; DSRM; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SMART; SM00949; PAZ; 1.
DR   SMART; SM00535; RIBOc; 2.
DR   SUPFAM; SSF101690; SSF101690; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF69065; SSF69065; 2.
DR   PROSITE; PS51327; DICER_DSRBF; 1.
DR   PROSITE; PS50137; DS_RBD; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS50821; PAZ; 1.
DR   PROSITE; PS00517; RNASE_3_1; 1.
DR   PROSITE; PS50142; RNASE_3_2; 2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008227};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266};
KW   RNA-mediated gene silencing {ECO:0000256|SAAS:SAAS00703041}.
FT   DOMAIN       51    227       Helicase ATP-binding.
FT                                {ECO:0000259|PROSITE:PS51192}.
FT   DOMAIN      433    602       Helicase C-terminal.
FT                                {ECO:0000259|PROSITE:PS51194}.
FT   DOMAIN      630    722       Dicer dsRNA-binding fold.
FT                                {ECO:0000259|PROSITE:PS51327}.
FT   DOMAIN      891   1042       PAZ. {ECO:0000259|PROSITE:PS50821}.
FT   DOMAIN     1281   1354       RNase III. {ECO:0000259|PROSITE:PS50142}.
FT   DOMAIN     1606   1764       RNase III. {ECO:0000259|PROSITE:PS50142}.
FT   DOMAIN     1789   1854       DRBM. {ECO:0000259|PROSITE:PS50137}.
FT   REGION      410    433       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1246   1283       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COILED      491    511       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS    412    427       Acidic. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   1868 AA;  211472 MW;  D1ABCD3BF4D72EB7 CRC64;
     MKSPALQPLS MAGLQLMTPA SSPMGPFFGL PWQQEAIHDN IYTPRKYQVE LLEAALDHNT
     IVCLNTGSGK TFIAVLLTKE LSYQIRGDFN RNGKRTVFLV NSANQVAQQV SAVRTHSDLK
     VGEYSNLEVN ASWTKEKWNQ EFTKHQVLVM TCSVALNVLK NGYLALSDIN LLVFDECHLA
     ILDHPYREIM KLCENCPSCP RILGLTASIL NGKCDPEELE EKIQKLEKIL KSNAETATDL
     VVLDRYTSQP CEIVVDCGPF TDRSGLYERL LMELEEALNF INDCNIAVHS KERDSTLISK
     QILSDCRAVL VVLGPWCADK VAGMMVRELQ KYIKHEQEEL HRKFLLFTDT FLRKVHALCE
     GHFSPAALDL RFVTPKVIKL LEILRKYKPY ERQQFESVEW YNNRNQDNYV SWSDSEDDEE
     DEEIEEKEKP ETNFPSPFTN ILCGIIFVER RYTAVVLNRL IKEAGKQDPE LAYISSNFIT
     GHGIGKNQPR NKQMEAEFRK QEEVLRKFRA HETNLLIATS IVEEGVDIPK CNLVVRFDLP
     TEYRSYVQSK GRARAPISNY VMLADTDKIK SFEEDLKTYK AIEKILRNKC SKSVESGETD
     LEPVVDDDDI FPPYVLRPDD GGPRVTINTA IGHINRYCAR LPSDPFTHLA PKCRTRELPD
     GTFYSTLYLP INSPLRASIV GPPMSCIRLA ERVVALICCE KLHKIGELDD HLMPVGKETV
     KYEEELDLHD EEETSVPGRP GSTKRRQCYP KAIPECLRDS YPKPDQPCYL YVIGMVLTTP
     LPDELNFRRR KLYPPEDTTR CFGILTAKPI PQIPHFPVYT RSGEVTISIE LKKSGFTLSL
     QMLELITRLH QYIFSHILRL EKPALEFKPT DADSAYCVLP LNVVNDSSTL DIDFKFMEDI
     EKSEARIGIP STKYSKETPF VFKLEDYQDA VIIPRYRNFD QPHRFYVADV YTDLTPLSKF
     PSPEYETFAE YYKTKYNLDL TNLNQPLLDV DHTSSRLNLL TPRHLNQKGK ALPLSSAEKR
     KAKWESLQNK QILVPELCAI HPIPASLWRK AVCLPSILYR LHCLLTAEEL RAQTASDAGV
     GVRSLPVDFR YPNLDFGWKK SIDSKSFISV ANSSSAENEN YCKHSPLVPE HAAHRGANRP
     SALENHGHTS VTCRALLSES PAKLPIDVAT DLTAVNGLSY NKNLANGSYD LANRDFCQGN
     HLSYYKQEIP VQPTTSYPIQ NLYNYENQPQ PSDECTLLSN KYLDGNANKS TSEGRPTMPG
     TTEAGKALSE RMASAQSPAP GYSPRTLGPN PGLILQALTL SNASDGFNLE RLEMLGDSFL
     KHAITTYLFC TYPDAHEGRL SYMRSKKTKD CVLANGRLDA DLEEEDAAAL MWRPPREEAE
     DDEDLLEYDQ EHIRFIDSML MGSGAFVKKI ALAPFAAADP AYEWKMPKKA PLGSMPFSAD
     FEDFDYSSWD AMCYLDPSKA VEEDDFVVGF WNPSEENCGV DTGKQSISYD LHTEQCIADK
     SIADCVEALL GCYLTSCGER AAQLFLCSLG LKVLPAVKRT DRAQAACPAR ESFTSQQKTL
     SGGRPAAGSR SSGLKDLEYG CLKIPPRCMF DHPDADRTLS HLISGFENFE RKINYSFKNK
     AYLLQAFTHA SYHYNTITDC YQRLEFLGDA ILDYLITKHL YEDPRQHSPG VLTDLRSALV
     NNTIFASLAV KYDYHKYFKA VSPELFHVID DFVQFQLEKN EMQGMDSELR RSEEDEEKEE
     DIEVPKAMGD IFESLAGAIY MDSGMSLEVV WQVYYPMMRP LIEKFSANVP RSPVRELLEM
     EPETAKFSPA ERTYDGKVRV TVEVVGKGKF KGVGRSYRIA KSAAARRALR SLKANQPQSI
     FIWTSTTI
//
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