ID A0A287A2M3_PIG Unreviewed; 7776 AA.
AC A0A287A2M3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Dystonin {ECO:0000313|Ensembl:ENSSSCP00000038187.2};
GN Name=DST {ECO:0000313|Ensembl:ENSSSCP00000038187.2};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000038187.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000038187.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000038187.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000038187.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR Ensembl; ENSSSCT00000061305.3; ENSSSCP00000038187.2; ENSSSCG00000001499.5.
DR GeneTree; ENSGT00940000155008; -.
DR Proteomes; UP000008227; Chromosome 7.
DR Bgee; ENSSSCG00000001499; Expressed in dorsal plus ventral thalamus and 42 other cell types or tissues.
DR ExpressionAtlas; A0A287A2M3; baseline and differential.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR CDD; cd21239; CH_DYST_rpt2; 1.
DR CDD; cd00051; EFh; 1.
DR CDD; cd00176; SPEC; 17.
DR Gene3D; 1.20.58.1060; -; 1.
DR Gene3D; 1.20.58.60; -; 31.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.920.20; Gas2-like domain; 1.
DR Gene3D; 3.90.1290.10; Plakin repeat; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR041615; Desmoplakin_SH3.
DR InterPro; IPR041573; Desmoplakin_Spectrin-like.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR003108; GAR_dom.
DR InterPro; IPR036534; GAR_dom_sf.
DR InterPro; IPR049538; PCN-like_spectrin-like_rpt.
DR InterPro; IPR043197; Plakin.
DR InterPro; IPR035915; Plakin_repeat_sf.
DR InterPro; IPR001101; Plectin_repeat.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR23169; ENVOPLAKIN; 1.
DR PANTHER; PTHR23169:SF21; EPIPLAKIN; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF02187; GAS2; 1.
DR Pfam; PF00681; Plectin; 1.
DR Pfam; PF17902; SH3_10; 1.
DR Pfam; PF00435; Spectrin; 20.
DR Pfam; PF18373; Spectrin_2; 1.
DR Pfam; PF21019; Spectrin_3; 1.
DR Pfam; PF21020; Spectrin_4; 1.
DR Pfam; PF21097; SR_plectin_7; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM01129; DELLA; 1.
DR SMART; SM00054; EFh; 2.
DR SMART; SM00243; GAS2; 1.
DR SMART; SM00250; PLEC; 10.
DR SMART; SM00150; SPEC; 33.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF143575; GAS2 domain-like; 1.
DR SUPFAM; SSF75399; Plakin repeat; 2.
DR SUPFAM; SSF46966; Spectrin repeat; 28.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS51460; GAR; 1.
DR PROSITE; PS50002; SH3; 1.
PE 1: Evidence at protein level;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A287A2M3};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 339..443
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 1067..1124
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 7364..7399
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 7400..7435
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 7440..7520
FT /note="GAR"
FT /evidence="ECO:0000259|PROSITE:PS51460"
FT REGION 16..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 184..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2230..2262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2286..2307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2413..2433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2474..2644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2681..2866
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2887..3023
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3100..3137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3153..3265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3352..3374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3456..3517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7527..7550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7564..7658
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7683..7776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 914..948
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1289..1316
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1388..1422
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1598..1628
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3886..3920
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4006..4073
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4473..4540
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4725..4752
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4939..4973
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 5224..5258
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 5374..5442
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 6361..6388
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 6613..6651
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 7122..7149
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 16..45
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2230..2249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2484..2498
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2586..2607
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2726..2745
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2761..2775
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2803..2817
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2824..2838
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2839..2853
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2887..2907
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2977..2991
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3104..3121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3171..3209
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3245..3263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3461..3475
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3476..3490
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3491..3514
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7530..7547
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7580..7605
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 7776 AA; 871187 MW; 0F9968FAEF7624A6 CRC64;
MGNVCGCVRA EKEEQFLDPA KTPLRPEKCS AGRRKYFRRD PTKESGTDPQ SGGAKHEQEK
RSAPRLPGAG VAPWPRALLR EGHACPSLAL EEGVRQGCGG SSFTPEEGVQ QGCVSPSLAL
EEGVQQGCGS PSLALEEGVR QGRGGPSLAL EEGVRQGCGG SSLALEEGVQ QGCGGSSFTL
EEGVQHRKVS SQSHLGGPSP AQGCETEVRV NELEEGISED STPHCAKGME PLDDANAGEI
TFQRNRDGSA FQTAASLPRM HGGPERSLEK CEFLEDPAKN DSSVQEKQGT ERFCPHATEH
FQFEEKSCRS LCTNVFLSSK DADGKEISDI HVTGESEDMS AKERLLLWTQ QATEGYAGIR
CENFTTCWRD GKLFNAIIHK YRPDLIDMNT VAVQSNLANL EHAFYVAEKI GVIRLLDPED
VDVSSPDEKS VITYVSSLYD AFPKVPEGGE GISANDVEVK WIEYQNMVNY LIQWIRHHVT
TMSERTFPNN PVELKALYNQ YLQFKETEIP PKETEKSKIK RLYKLLEIWI EFGRIKLLQG
YHPNDVEKEW GKLIIAMLER EKALRPEVER LEMLQQIASR VQRDSVVCED KLLLARNALQ
ADSKRLESGV QFQNEAEVAG YILECENLLR QHVIDVQILT DGKYYQADQL VQRVAKLRDD
IMALRNECSS MYSKGRVLTT EQTRLMISGI TQSLNSGFAQ TMNSSLNSGL TPSLTPPSVT
SGLTSRLTPS VTPAYTPGFP SGVLPNFSSG VETNSLQTLK LMQIRKPLMK SSLLDQNLTE
EEINMKFVQD LLNWVDEMQV QLDRTEWGSD LPSVESHLEN HKNVHRAIEE FEASLKEAKI
SEIQMTAPLK LTYTEKLHRL ESQYAKLLNT SRNQERHLDT LHNFVTRATN ELIWLNEKEE
EEVAYDWSER NTNIARKSEY HAELMRELDQ KEENIKAVQE IAEQLLLENH PARLTIEAYR
AAMQTQWSWV LQLCQCVEQH IKDNSAYFEF FNDAKEAADY LRNLKDAIQR KYSCDRSSSL
HKLEDLLQES MEEKEELLQY KSTVASLMGR AKTIIQLKPR NPDCSLKTSI PIKAICDYRQ
IEITIFKDDE CVLANNSHRA KWKVISPTGN EAMVPAVCFT IPPPNKEAVD FANRIEQQYQ
NVLTLWHESH INMKSVVSWH YLVSEIDRIR ASNVASVKTM LPGEHQQVLS NLQSRFEDFL
EDSQESQIFS GSDITQLEKE VNVCKQYYQE LLKSAEREEQ EESAYNLYIS EVRNLRLRLE
SCEDRLIRQI RTPLERDDLQ ESVFRLGEQE KLKKELERLK DDLATITNKC EDFFSQAAAS
SSAPTLRSEL SVVVQSMNHV YSMSSTYIEK LKTVNLVLKN TQAAEALVKL YETKLCEEEA
VIADKNNIEN LISTLKRWRS EVDEKREVFH ALEDELQRAK TISDEMFKTY KERDLDLDWH
KEKADQLVER WQNVHIQIDN KLRDLEGLGK SLKQYRDSYH PLDDWIQQVE TTQRKIQENQ
PENSKTLATQ LNQQKMLVSE IEMKQSKMDE CQKFAEQYSV AVKDYELQTM TYRAMVDSQQ
KSPVKRRRVQ SSADLVIQEF MDLRTRYTAL VTLMTQYIKF AGDSLKRLEE EEKSLDEEKK
EHVEKAKELQ KWVSSISKTL RDGEKAGRSS LSRPKISSEE ISVKKEQLSE ALQTMQLFLA
KHGDKMTDEE RMELEKQVKT LQESYSVFFS ESLKQLQQLQ TSAEIKVEEK LDKVIAGTVD
RSTGEVLSIF QAVLRGLVDY DTGIRLLETQ LLISGLISPA LRKCFDLKDA QSHGLIDEQV
LSHLQELNEA KAVMSAVSPA TVPVLDALAK GVISEPTAIR VLEILLSTGS LVIPATGEQL
TLQKAFQQHW ISSALFSKIL ERQNTCKDLI DPSTSEKVSL LDLLQRSVLQ ENTGVRLLPV
RPQEGGRITL KGGRSISILR AAHEGLVDRE TMFRLLGAQL LSGGLIDATS GRRLTVEEAV
AEGVMDRDTA NSILTYQVET GGIIHSNPAR RLTVDEAVQC DLITSSSALL VLEAQRGYVG
LIWPHSGEIF PTSSSLQQEL ITNELACKIL NGRQKIAALY MPETSQVVGL ELAAQLGIID
NNTASILKNI VLPDKMPDLR DLEACKNARR WLSFCKFQPS TAHDYRPEED VFDEEEPVAT
QSSEQTKKLF LSYLMINSYM DANTGQRLLL YDGALGEAVE MLHEGCGAEL GEDTPGKEGL
GVLGLPGVFP SHTSSTETGE STASPSSWET CHGREPKHKE VPENRKQAFD EMCQDMGTDV
PRSEIRPSGN PAGRLAAGPQ VSSSSVCLPG SPARLTQPGL AEVLGQESTN RLENGEHQKQ
IETKDRADEC RPSVNLLNLA SGLIPDPLVK SKTGRICDMN EAECEDGVSR RSALFDYSPR
LSALLSHDKL RTHPGGREHV HPAESNGHPR EASALPVSDQ TMPLGQRMGA GFQDQFLGIA
AINISLQGEH AVQKPSHVGC DRPQMQNQDH KDSSDACGGD EEMLASAWQK PEDKPRASPG
EGRACASSLR GTGAQAPPAD AHSPVFEEPA GAGAGDYETS LLDHGQSDTE TDTESSEDFY
DTPLSEDDDH DSLLLQGDDR DCLQPEDCDS LPEEEDRAAP PGEVFYDVSK EGAPGAPADG
FSVGGEAESL QGFLVGSETP ELSSGGGLHF SALGSYEGGG PWTETAWEMD GPDHLDSDES
DSLSDGDLGG GEEGFRTALE PDDTGSWGGR EGERAAGREL KPKAGHLDPT QNGDSCGDSV
CDSGGDDDDG DAEEEGAGSE GGKPMTQGEA EDAGVGAGVA AVHEAESHRE TQESNQMILP
DEKHSPSPSE KQQDVHVLRL ESSSESSLVA ERNNLPEPTM ECVQKSKGHV LRHEMALKDV
LQPVVKGTES GNTLGPVRVS PNPDVSSASE LEYELKNMGG ELIQGPGSAD AVEGGHPYCE
NVTLQADSSS EKEEPDAVGT PGRECQSSTP VSAVDQGDRG RRGEQVEERA VGGRVPPEGG
TSGRQACADE GEVPTEGPAE GDACRQLLPS ERTREHLGLA NSQLPVPHIA VSEHPQEGSL
HRAAVTLTEE ARSPPAMVSK SPVQFEDLEE IFDSPVCQVM GGDATSGLTL SEGNTRTQRE
PVTPGPEREP PLLTHLKPCA PNVKAKDVLK LNGDAPSSVL PASLPRKEHL QSGVKNAEDE
ARLALEESPL MEGAQRDDIP AKESDSEGGT EGPEFALENG ETPPASPLRR VGGLGKHTDS
VQSELCADGI RSDSSSGPLS PDFSSLEINH KEDILKQPPQ KAQASFPGLR EKEVQVPGVS
QVCAEDVKDA LKGRLEECHR TPQEAEEPST CADAKISIQN LIKSVSASLL VPEASGGHSD
SETGDRPGAS PLINSPELQA EDRADPFCIA NLKSELPPHT LRQNQPSQKI TGALELMKEL
TRMGCELEKG GVTSEGLPGQ LGSIFSKLFA DGYSEKVEQG GNLGPESSTA SEQVDEQPHV
PDDLKSKEGN HCSLHVQTAN DSGPENSPTS ASASPRDGRL EELFTKSPNH LECISRSKEM
ASGDSTMGQF SNEMQQCLQH RSKMCEYLAL LQDMKPPLDN WESPENNLEA LKNQLKQLEM
FELGLTPIAV ILRKDMELAE EFLKSLPADF PRGPLEDLHL SLQSLRSAFS SLSTASSERM
THITWAINSE TSKLAVSHEE FLHRLQSFSC WVSEKSRSVK GMEAVKVQDT EHVRQSLEFL
KNVLKDLGHT KTQLEATAFD VQFFISEHAQ DLSPTQSRQL LNLLNTTQKG ILDAQGSVAA
QVERLEAQLQ LEQELDHQKV VAERQQEYRE KLQGICDLLT QTENRLIGHQ EAFVIGDGTA
DLKKYQSRQE ELQKDMQGSA QALAEIVKNT ENFLKECGEK LSQEDKALIE QKLNEAKIKC
EQLNLKAEQS RKELDKVVTT AIKEETEKVA AVKQLEESKT KIENLLDWLS NVDRDSGRAE
MEQKQVIEQN GTHFQEDDGK SVMGEEDEVN GNLLDTDVDG QVGAPEENLN QQYQRMKAQH
EELAAQHQAV LLATQAAQAL LDKQGHHLSP EEREKLQRKA KELQAHYQTA LAESERRVRL
TRSLREELEK FEADCGEFEL WLQQSEQELV NLEAGADDLA GLRAKLKRQR SFSEDVISHK
GDLRYITISG SRVLEAAKSC SRREGGGRAE PVDTSATHRE VQARLDRATD RFRSLYTKCN
VLGNNLKDLV DKYQHYEDAS CGLLSGLQAY EASASRHLSE PIAVDPENLQ RQLEETKVLQ
GQISSQQVAV EKLKKTAEVL LDARGSLLPA KNDIQKTLDD IVGRYDSLSR SVSERNEKLQ
VTVTRSLSVQ DGLDEMLDWM GGVERSLRED GQVPLNSAAL QDIISKNIML DQDISGRQSR
LKAMTEKVER FTETSDPSTA SSLQARVKDL SLRFSEASHR HKEKLAKMEE LKTKVELFEN
LSEKLQTFLE TKTQALTEAD VPGRDVTELS QYLQESTYEL QECKKDLEVL QNLLKEISNH
GLPGDKALVF EKTNNLSKKF REMEDTVKEK KEAVSSCQEQ MDAFQVLVQS LKSWIKETTE
RVPVVQSSFG AEDLGKSLEE TKKLQEKWSL KTPEIQKVSN SGISLCNLIS AVTTPAKAIA
AVKSGGVILN GDGTATDTQE ILGNKELTSV KKDMTDISHD YEDLGLLLKD KIAELNTKLS
KLQKAQDESS AMMQWLQKMN TTATMWQQAP TPTDTEAVKS QVEQNKLFEA ELKQNVNKVQ
ELKDKLTELV EENPDAPEAP KWKQMLKEID SKWQDLNQFT VERQQKLEES SNNLTQFQTI
EAQLKQWLVE KELMVSVLGP LSIDPNMLNT QRQQVQILLQ EFETRKPQYQ QLTAAGQSIL
NRPGEHPAFH GVVKEQLAAV TQKWDSLTGQ LKDRCERIDQ AILKSTQYQS LLRRLAEKLA
DVDEKLSSKA AGGATPDAMN QQLETAQKVK QEIEQESKQI RVAQALCEEL SALVREEYLK
AELGRQLEGI VKSFKDVEQR AENHVQHLQS ACASSHQFQQ MSRDFQTWLE TKKEEQSKAP
PISAKLEILE SLIKDQKDFR RTLTAQSHIY EKTIAEGETL LFKTQGAEKV ALQSQLNTMK
TNWDGFNKLV REREDRVKDS LEKALKYKEH VESLRPWIDR CQNSLEEIKF GLDPAEMETS
LGRLKSLQKD MDQHFGMVEQ LEGAASSLLS VCEADREGVA EEKDALVQKV DLVTEQVHKK
KFSLESLAQK FKEFQEVSKE AQRQLQGAKE QLDGLESLGP QAHSSKSLTM LQTQQKALQT
LRPQVDLAQG LAKDLVAGAS DPGGTSEVLL QAESLAQEHS ALSQQVEEKC SFLETKLQGI
GHFQNTIREM FSQFAEFDDE LDSMAPVGRD GETLQKQKEA IEAFLKKLEA LIASNANANK
TCKMMLATEE ACPDLVGIRR DLEALSKQCN KLRDRAQARE EQVLGTVARL EEFYSKLKEF
CTLLQDAEEH EESQGPVGME TEAINQQLEV FKVFQKEEIE PLQVKQQDVN WLGQGLIQSA
AKGTSTQALE HDLDSASTRW KTLNKKVAQR AAELQEALLH CGRFQDALES LLSWMEDTEE
LVAHQKPPSA EFKVVKAQIQ EQKLLQRLLD DRKSTVEVIK REGEKIAATA EPADKVKILK
QLSLLGSRWE ALLSKAESRN RQLEGISVVA QQFHETLEPL NEWLTTVEKR LANCEPIGTQ
ASKLEEQIAQ HKALEDEIIH HSKHLHQAVS VGQSLKVLSS REDRDVVQSQ LDSSQVWYIE
IQEKSHSRSE LLQQALCNAK IFGEDEVELM NWLSEVHGKL SRLSVQDFSL EGLWTQQAEL
RVLQEDILLR KQNVDQALLN GLELLKQTTG DEVLIIQDKL EAIKARYKDI TKLSTDVAET
LEQALQLARR LHTTHEELCT WLDAVESEML SYETQVLKGD AAGQAHARQK ELKKEAKSSR
ALLDSLNEVS AALLELVPWR AREGLEKMVA EDNERFRLVS DTITQRVEEM DAAVLRAQQF
DQAADAELSW ITETEEKLAS LGDIRLEQDQ TSAQLQVQKT FTMEILRHKD LIDELVNSGH
QLMSTCSEEE KQAMKKKLDK VLKNYDAICQ MNSERYLQLE RAQSLVNQFW ETYEELWPWL
MDTQQTISQL PAPALEYETL RQQQEEHRQL RELIAEHKPH IDKMNKTGPQ LLELSPREGF
SIQEKYVAAD TLYSQIKEDV KRRAMALDEA ISQSTQFHDK IDQILESLER IVERLRQPPS
ISAEVEKVKE QISENKNVAV DMEKLQPLYE TLRKRGEEMI ARSQGTDKDI SAKAVQDKLD
RMVFIWENIH TLVEEREAKL LDVMELAEKF WCDHMSLVVT TKDTQDFIRD LEDPGIDPSV
VKQQQEAAEA VREEIDGLQE ELDMVINLGS ELMAACGDPD KPIVKKSIDE LNSAWDSLNK
AWKDRVDRLE EAMQAAVQYQ DGLQAIFDWV DIAGGKLASM SPVGTDLETV KQQMEELKQF
KSEAYQQQIE MERLHHQAEL LLKKVTEESD KHTVLDPLME LKLIWDSLDE RIVNRQHKLE
GALLALGQFQ HALDELLVWL THTEDLLGEQ KPVGGDPKAI EIELAKHHVL QNDVLAHQST
VEAVNKAGND LIASSAGEEA SSLQNKLEVL NQRWQNVLEK TEQRKQQLDG ALRQAKGFHG
EIEDLQQWLS DTERHLLASK PLGGLPETAR EQLNAHLEIC AAFDGKEEIY KSLVQRGQQV
LERCPQSAET NIDQDINNLK EKWESVETKL NERKVKLEEA LALAVDFHNS LQDFINWLTQ
AEQTLNVASR PSLILDTVLF QIDEHKVFAN EVNSHREQII ELDKTGTHLK YFSQKQDVVL
IKNLLISVQS RWEKVVQRLV ERGRSLDDAR KRAKQFHEAW SKLMEWLEES EKSLDAELEI
ANDPDKIKTQ LAQHKEFQKS LGAKHSVYDT THRTGRSLKE KTSLADDNLK LDDMLSELRD
KWDTICGKSV ERQNKLEEAL LFSGQFTDAL QALIDWLYRV EPQLAEDQPV HGDIDLVMNL
IDNHKVFQKE LGKRTSSVQA LKRSARELVE GSRDDSSWVR VQMQELSTRW ETVCALSISK
QTRLEAALRQ AEEFHAVVHA LLEWLAEAEQ TLRFHGVLPD DEDALRTLID QHKEFMKRLE
EKRTALNKAT TMGDAILAIC HPDSITTIKH WITIIRARFE EVLAWAKQHQ QRLASALAGL
IAKQELLEAL LAWLQWAETT LTDKDKEVIP QEIEEVKALI AEHQSFMEEM TRKQPDVDKV
TKTYKRRAAD PSSLQSHIPV LDKGRAGRKR FPASSFYPSG SQTQIETKNP RVNLLVSKWQ
QVWLLALERR RKLNDALDRL EELREFANFD FDIWRKKYMR WMNHKKSRVM DFFRRIDKDQ
DGKITRQEFI DGILSSKFPT SRLEMSAVAD IFDRDGDGYI DYYEFVAALH PNKDAYKPIT
DADKIEDEVT RQVAKCKCAK RFQVEQIGDN KYRGLLSSSP QFGDSQQLRL VRILRSTVMV
RVGGGWMALD EFLVKNDPCR VHHHGSKMLR SESNSSITTT QPTIAKGRTN MELREKFILA
DGASQGMAAF RPRGRRSRPS SRGASPNRST SVSSQAGQAA TPPVPATSTP KILHPLTRNY
GKPWLTNSKV STPCKPAECS DLPMSSPEGT PIQGSKLRLP GYLSGKGFHS GEDSGLITTA
AARVRTQFPD PKKTPSRPGS RAGSKAGSRA SSRRGSDASD FDISEIQSVC SDVEAVPPTH
RPTPRARSRP SSAKPSKIPT PQRRPAASKV DKSSKR
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