ID A0A287A372_PIG Unreviewed; 1178 AA.
AC A0A287A372;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Sorbin and SH3 domain containing 2 {ECO:0000313|Ensembl:ENSSSCP00000038403.2};
GN Name=SORBS2 {ECO:0000313|Ensembl:ENSSSCP00000038403.2,
GN ECO:0000313|VGNC:VGNC:96030};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000038403.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000038403.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000038403.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000038403.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A287A372; -.
DR Ensembl; ENSSSCT00000047343.3; ENSSSCP00000038403.2; ENSSSCG00000036679.3.
DR VGNC; VGNC:96030; SORBS2.
DR GeneTree; ENSGT00940000157056; -.
DR Proteomes; UP000008227; Chromosome 15.
DR Bgee; ENSSSCG00000036679; Expressed in heart left ventricle and 44 other cell types or tissues.
DR ExpressionAtlas; A0A287A372; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd11920; SH3_Sorbs2_1; 1.
DR CDD; cd11923; SH3_Sorbs2_2; 1.
DR CDD; cd11917; SH3_Sorbs2_3; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR003127; SoHo_dom.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR14167:SF56; DREBRIN-LIKE PROTEIN-RELATED; 1.
DR PANTHER; PTHR14167; SH3 DOMAIN-CONTAINING; 1.
DR Pfam; PF00018; SH3_1; 2.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 3.
DR SMART; SM00459; Sorb; 1.
DR SUPFAM; SSF50044; SH3-domain; 3.
DR PROSITE; PS50002; SH3; 3.
DR PROSITE; PS50831; SOHO; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A287A372};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 138..197
FT /note="SoHo"
FT /evidence="ECO:0000259|PROSITE:PS50831"
FT DOMAIN 910..969
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 985..1046
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1119..1178
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 35..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 182..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 878..911
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..66
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..213
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..234
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..265
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..298
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 332..358
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 882..897
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1178 AA; 132957 MW; 6DB33415A1CB3924 CRC64;
MYMILCQIIF TGLFISLFRV LISTFLFLLG RDSQSPDSAK GFRSVRPNLQ EKKSPTQSQI
TVNGNSGGTV SPMSYYQRPF SPSAYSLPGS FNSSIIMQHG RSLDSTDTYP QHAQSLDGTM
GSSIPLYRSS EEEKRVTVIK APHYPGIGPV DESGIPTAIR TVGNASARRS GAVHRLHKGL
YNSPYSAQSH PAAKTQTYRP LSKSHSDNGT DAFKDASSPV PPPHVPPPVP PLRPRDRSST
EKHDWDPPDR KVDTRKFRSE PRSIFEYEPG KSSILQHERP ASLYQSSIDR SLERPASSAS
MASDFRKRRK SEPAVGQPRG LGDPSASRTS PGRADLPGSS TTLTKSFISS SPSSPSRAKG
GDDSKMCPSL CSYSGLNGNP SHELDYCNTY RQHLDVPHDS QRAIAFKNGW QMARQNAEVW
SSTEETVSPK IKSRSCDDLL NDDCDSFPDP KTKSESMGSL LCEEDSKESC PIPWASPYIQ
EGRSRLRYRS AHNAPGFLKM YKKMHRINRK DLMNSEVICS VKSRIMQYEK EQQHKGLLHG
WSQSSTEEVP RDMVPTRISE FEKLIQKSKS MPNLGDEMLS PVTLEPQQNG LCPKRRFSIE
SLLEEENQSR HPSQVQRSYT SKTLVPIHIE VTSDEQPRTH MEFSDSDQDG VVSDHSDYIH
VEGSSFCSES DFDHFSFTSS ESFYGSSHHH HHHHHHHHRH LISTCKGRCP ASYTRFTTML
KHERAKHENT EEPRRQEMDP GLSKLAFLVS PVPFRRKKNS TPKKQTEKAK CKASVFEALD
SALKDICDQI KAEKRRGSLP DNSILHRLIS ELLPDIPERN SSLKALKRSP MHQPFHPLPQ
DGAIHCPLYQ NDCGRLPHSA SFPDDTNNNY HQDHDSALSL QDHESPRSYS STLTDLGRST
SRERRVTPEK EKLPAKAVYD FKAQTSKELS FKKGDTVYIL RKIDQNWYEG EHHGRVGIFP
ISYVEKLTPP EKAQPARPPP PAQLGEIGEA VAKYNFSADT NVELSLRKGD RVILLKRVDQ
NWYEGKIPGT NRQGIFPVSY VEVVKKNTTK GAEEYPDPPI PHSYSSDRIH SLSSNKILVL
MLSLKRKETL LRVQCTGNFY QYFSSKPQRP VFTHENIQGG GEPFQALYNY TPRNEDELEL
RESDVIDVME KCDDGWFVGT SRRTKFFGTF PGNYVKRL
//
