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Database: UniProt
Entry: A0A287A3A8_PIG
LinkDB: A0A287A3A8_PIG
Original site: A0A287A3A8_PIG 
ID   A0A287A3A8_PIG          Unreviewed;       470 AA.
AC   A0A287A3A8;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   16-OCT-2019, entry version 15.
DE   RecName: Full=Protein C-ets-2 {ECO:0000256|PIRNR:PIRNR001698};
GN   Name=ETS2 {ECO:0000313|Ensembl:ENSSSCP00000038432};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
OC   Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000038432, ECO:0000313|Proteomes:UP000008227};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000038432, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000038432,
RC   ECO:0000313|Proteomes:UP000008227};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSSCP00000038432}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2017) to UniProtKB.
CC   -!- FUNCTION: Transcription factor. {ECO:0000256|PIRNR:PIRNR001698}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR001698,
CC       ECO:0000256|RuleBase:RU004019, ECO:0000256|SAAS:SAAS00594387}.
CC   -!- SIMILARITY: Belongs to the ETS family.
CC       {ECO:0000256|PIRNR:PIRNR001698, ECO:0000256|RuleBase:RU004019,
CC       ECO:0000256|SAAS:SAAS00594391}.
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DR   EMBL; AEMK02000093; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSSSCT00000052410; ENSSSCP00000038432; ENSSSCG00000038948.
DR   GeneTree; ENSGT00940000160202; -.
DR   OMA; RSWNSQS; -.
DR   Reactome; R-SSC-2559585; Oncogene Induced Senescence.
DR   Proteomes; UP000008227; Chromosome 13.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR   GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0001712; P:ectodermal cell fate commitment; IEA:Ensembl.
DR   GO; GO:0007498; P:mesoderm development; IEA:Ensembl.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:Ensembl.
DR   GO; GO:0090009; P:primitive streak formation; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR016311; Transform_prot_C-ets.
DR   InterPro; IPR027276; Transform_prot_C-ets-2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PIRSF; PIRSF501032; C-ets-2; 1.
DR   PIRSF; PIRSF001698; Transforming_factor_C-ets; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008227};
KW   DNA-binding {ECO:0000256|PIRNR:PIRNR001698,
KW   ECO:0000256|RuleBase:RU004019, ECO:0000256|SAAS:SAAS00594397};
KW   Nucleus {ECO:0000256|PIRNR:PIRNR001698, ECO:0000256|RuleBase:RU004019,
KW   ECO:0000256|SAAS:SAAS00594400};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW   Transcription {ECO:0000256|PIRNR:PIRNR001698};
KW   Transcription regulation {ECO:0000256|PIRNR:PIRNR001698}.
FT   DOMAIN       85    170       PNT. {ECO:0000259|PROSITE:PS51433}.
FT   DOMAIN      364    444       ETS. {ECO:0000259|PROSITE:PS50061}.
FT   REGION      270    290       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   470 AA;  52748 MW;  4F6F667082C71F1A CRC64;
     MNDFGIKNMD QVAPVSNSYR ATLKRQPAFD TLDGSLLSVF PPLNEEQTLQ EVPTGLDSIS
     HDSTNCELPL LTPCSKAVMS QALKATFSGF KKEQCRLGIP KNPWLWTEQQ VCQWLLWATN
     EFSLVDVNLQ RFGMTGQVLC NLGKERFLEL APDFVGDILW EHLEQMIKEN QEKTEEQYEE
     NSPLNSVPQW INSNSLGFGV EQTPYGVQTQ NYPKGSLLDS LCPASSAPST LGPEQDFQMF
     PKARLSTVSV NYCSVSQDFA GSSLNLLSSS AGKPGDHDAP ENGADSFESS ESLLQSWTSQ
     SSLLDVQRVP SFESFEDDCS QSLCLNKPTM SFKDYIQERS DPVEQGKPVI PAAVLAGFTG
     SGPIQLWQFL LELLSDKSCQ SFISWTGDGW EFKLADPDEV ARRWGKRKNK PKMNYEKLSR
     GLRYYYDKNI IHKTSGKRYV YRFVCDLQNL LGFTPEELHA ILGVQPDTED
//
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