ID A0A287A3N7_PIG Unreviewed; 2799 AA.
AC A0A287A3N7;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=LPS responsive beige-like anchor protein {ECO:0000313|Ensembl:ENSSSCP00000038505.1};
GN Name=LRBA {ECO:0000313|Ensembl:ENSSSCP00000038505.1,
GN ECO:0000313|VGNC:VGNC:98074};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000038505.1, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000038505.1, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000038505.1,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000038505.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSSSCT00000046874.3; ENSSSCP00000038505.1; ENSSSCG00000009021.5.
DR VGNC; VGNC:98074; LRBA.
DR GeneTree; ENSGT00940000154778; -.
DR ChiTaRS; LRBA; pig.
DR Proteomes; UP000008227; Chromosome 8.
DR Bgee; ENSSSCG00000009021; Expressed in penis and 44 other cell types or tissues.
DR ExpressionAtlas; A0A287A3N7; baseline and differential.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR046851; NBCH_WD40.
DR InterPro; IPR010508; NBEA-like_DUF1088.
DR InterPro; IPR031570; NBEA/BDCP_DUF4704.
DR InterPro; IPR046852; Neurobeachin_a-sol.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF64; LIPOPOLYSACCHARIDE-RESPONSIVE AND BEIGE-LIKE ANCHOR PROTEIN; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF06469; DUF1088; 1.
DR Pfam; PF15787; DUF4704; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF20426; NBCH_WD40; 1.
DR Pfam; PF20425; Neurobeachin; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A287A3N7};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 2065..2173
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2192..2490
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 2711..2752
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 943..1024
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1074..1218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1258..1298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1463..1487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1557..1635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1761..1781
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 952..986
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 996..1024
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1074..1088
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1117..1141
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1143..1173
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1176..1202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1264..1286
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1463..1483
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1567..1598
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1613..1628
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2799 AA; 311202 MW; 1AABE535CDF74D89 CRC64;
MASEDNNVPS PPPTGDDEGG GGKEETPAEG GALSLKPGLP IRGIRMKFAV LTGLVEVGEV
SNRDIVETIF NLLVGGQFDL EMNFIIQEGE SIICMVDLLE KCDVTCQAEV WSMFTAILKK
SIRNLQICTE VGLVEKVLGQ IEKADSMIAD LLVDMLGVLA SYNLTVRELK LFFSKLQGDK
GQWPPHAGKL LSVLKHMPQK YGPDAFFNFP GKSAAAIALP PIAKWPYQNG FTFHTWLRMD
PVNNINVDKD KPYLYCFRTS KGLGYSAHFV GGCLIITSIK SKGKGFQHCV KFDFKPQKWY
MVTIVHIYNR WKNSELRCYV NGELASYGEI TWFVNTSDTF DKCFLGSSET ADANRVFCGQ
MAAVYLFSEA LNAAQIFAIY QLGLGYKGTF KFKAESDLFL AEHHKLLLYD GKLSSAIAFT
YNPRATDAQL CLESSPKDNP SIFVHSPHAL MLQDVKAVLT HSIQSAMHSI GGVQVLFPLF
AQLDYKQYLS DEVDLTICST LLAFIMELLK NSIAMQEQML ACKGFLVIGY SLEKSSKAHV
SRAVLELCLA FSKYLSNLHN GMPLLKQLCD HILLNPAIWI HTPAKVQMTL YTYLSTEFIG
TVNIYNAIRR VGTVLLIMHT LKYYYWAVNP QDRSGITPKG LDGPRPNQKE MLSLRAFLLM
FIKQLVMKDS GVKEDELQAI LNYLLTMHED DNLMDVLQLL VALMAEHPNS MIPAFDERNG
LRVMYKLMAS TSEGIRVQAL KAMGYFLKHL APKRKAEIML GHGLFSLLAE RLMLQTNLIT
MTTYNVLFEI LIEQICTQVI HKQHPDPDSS VKIQNPQILK VIATLLRNSP QCPESIEVRR
AFLSDMIKLF NNSRENRRSL LQCSVWQEWM LSLCYFNPKN SDEQKITEMV YAIFRILLYH
AVKYEWGGWR VWVDTLSITH SKVTFEIHKE NLASVFREHQ GKVDEEIGPC SSSPDQAVSG
ISGDVNVGSQ QSDTKDSPVP SHITRNSDEK SSLEKTSSVE SASSAELQTC GTSNEERKTG
QNNQEFLDEV PLEETLTNET INAGSLEVSS DMTEAMAISS NSFKTTDKDV MTVSEVTASI
NSPSEEDSSE VPEVLDKSMV EEEDDDDYVE LKVESSPSEE ASPSTELQDN SLSTAASEAS
ERLDMFNNEH KLVFQEEEPA SKKQTDAETH DPKDSGILTM TASGSSATSP GTPASQATGP
SDIGQVLKEG EETTSFAGET KVISDSHGDI FESPTTSEQR IARLDVSSVA TDTERLELKA
STNMEAPQPH QPVLEMSRQQ EQPGRGTAPD AVNGQRRDSR SMFRIPEFRW SQMHQRLLTD
LLFSIETDIQ MWRSHSTKTV MDFVNSSDNV IFVHNTIHLI SQVMDSMIMA CGGILPLLSA
ATSATHELEN IEPTQGLSIE ASVTFLQRLI SLVDVLIFAS SLGFTEIEAE KNMSSGGILR
QCLRLVCAVA VRNCLECQQH SQLKNKGDTG KGQKTTHSLI SMGKSGAKSP VDIITGGISP
VRDFDRLLQD MDINRLRAVV FRDIEDSKQA QFLALAVVYF ISVLMVSKYR DILEPQNERP
GQSFKERGSE SENLSVPDVE SSSAALSPLT PPSVEESEST SSARRRDSGI GEETATGSGS
NVDITPPVAS PSVSAGPDAI SEVLCTLSLE VNKSQESKND GGHESDNKAA ASVSVSKNVN
VKDILRSLVN IPADGVTVDP ALLPPTCLGV LGDLSVEQPV QFRSFDRSVI IATKKSTVLP
STLTTSIPTN AVSVVSSVDS AQASDAGRES PGGRSSSAKL PAVPAVGSVP QDQVSNMSIT
ERLEHALEKA APLLREIFVD FAPFLSRTLL GSHGQELLIE GTSLVCMKSS SSVVELVMLL
CSQEWQNSIQ KNAGLAFIEL VNEGRLLSQT MKDHLVRVAN EAEFILSRQR AEDIHRHAEF
ESLCAQYSAD KREDEKMCDH LIRAAKYRDH VTATQLIQKI INILTDKHGA WGNSTVSRPR
EFWRLDYWED DLRRRRRFVR NPLGSTHPEA TLKTAVEHAA DEDILAKGKQ SIKSHALGNQ
NLENEILLEG DDDTLSSVEE KDLENLTGPV SLSTPAQLVA PSAVVKGTLS VTSSELYFEV
DEEDPNFRKM DPKILAYTEG LHGKWLFTEI RSVFSRRYLL QNTALEIFMA NRVAVMFNFP
DSATVKKVVN YLPRVGIGTS FGLPQTRRIS LASPRQLFKA SNMTQRWQHR EISNFEYLMF
LNTIAGRSYN DLNQYPVFPW VITNYESEEL DLTLPSNFRD LSKPIGALNP KRAAFFAERY
ESWEDDQVPK FHYGTHYSTA SFVLAWLLRI EPFTTYFLNL QGGKFDHADR TFSSISRAWR
NSQRDTSDIK ELIPEFYYLP EMFVNFNDYN LGVMDDGTVV SDVELPPWAR TSEEFVRINR
LAVESQIRSF GQTPSQLLIE PHPPRGSAMQ ASPLMFTDQA QQDVIMVLKF PSNSPVTHVA
ANTQPGLAIP AVITVTANRL FAVNKWHNLP AHQGAVQDQP YQLPVEIDPL IASNTGMHRR
QITDLLDQSI QVHSQCFVIT SDNRYILICG FWDKSFRVYS TDTGKLIQVV FGHWDVVTCL
TRSESYIGGN CYILSGSRDA TLLLWYWNGK SSGIGDNPGS ETTTPRAILT GHDYEVTCAA
VCAELGLVLS GSKEGPCLIH SMNGDLLRTL EGPENCLRPK LIQASREGHC VIFYENGFFC
TFSVNGKLQA TMETDDNIRA IQLSRDGQYL LTGGDNGVVM VWQVSDLKQL FAYPGCDAGI
RAMALSHDQR CIISGMASGS IVLFYNDFNR WHHEYQTRY
//
