ID A0A287A3P1_PIG Unreviewed; 1352 AA.
AC A0A287A3P1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Crumbs cell polarity complex component 1 {ECO:0000313|Ensembl:ENSSSCP00000038584.1};
GN Name=CRB1 {ECO:0000313|Ensembl:ENSSSCP00000038584.1,
GN ECO:0000313|VGNC:VGNC:96002};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000038584.1, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000038584.1, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000038584.1,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000038584.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR PaxDb; 9823-ENSSSCP00000026273; -.
DR Ensembl; ENSSSCT00000060692.2; ENSSSCP00000038584.1; ENSSSCG00000021897.4.
DR VGNC; VGNC:96002; CRB1.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00940000155152; -.
DR Proteomes; UP000008227; Chromosome 10.
DR ExpressionAtlas; A0A287A3P1; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 9.
DR CDD; cd00110; LamG; 3.
DR Gene3D; 2.60.120.200; -; 3.
DR Gene3D; 2.10.25.10; Laminin; 14.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24049; CRUMBS FAMILY MEMBER; 1.
DR PANTHER; PTHR24049:SF22; DROSOPHILA CRUMBS HOMOLOG; 1.
DR Pfam; PF00008; EGF; 9.
DR Pfam; PF12661; hEGF; 3.
DR Pfam; PF02210; Laminin_G_2; 3.
DR PRINTS; PR00010; EGFBLOOD.
DR SMART; SM00181; EGF; 15.
DR SMART; SM00179; EGF_CA; 13.
DR SMART; SM00282; LamG; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 9.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 7.
DR PROSITE; PS00022; EGF_1; 12.
DR PROSITE; PS01186; EGF_2; 8.
DR PROSITE; PS50026; EGF_3; 15.
DR PROSITE; PS01187; EGF_CA; 3.
DR PROSITE; PS50025; LAM_G_DOMAIN; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1290..1314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 135..173
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 175..211
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 213..249
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 251..290
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 292..346
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 348..390
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 392..432
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 434..617
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 619..655
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 661..832
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 834..870
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 871..907
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 897..1084
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1086..1122
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1124..1159
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1161..1197
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1202..1241
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1243..1279
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 24..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 144..161
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 163..172
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 201..210
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 239..248
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 336..345
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 422..431
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 645..654
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 860..869
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1112..1121
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1128..1138
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1149..1158
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1187..1196
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1231..1240
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1269..1278
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1352 AA; 146171 MW; 976E3395F00086AB CRC64;
MLRDTTALGI VVGVPVVLHE ELPEKKGQRW PRGSRRHTPL SEQAGWGARR DQTTSSRSEH
VRCETMALRT ALHLLTVCLS LSLLISIKNS FCNRNDTKCR SNSCPNNSTC KNFSKDNSCH
CSDTAINLDK DCDDEKDPCF SSPCPGNATC VSTPGERRFL CTCPPGYSGA TCDTVVSFCG
TNSCQHGGIC GQDPVHPVCI CPAGYAGRFC ELDHDECGSS PCRNGAMCQD GINGYSCFCV
PGYQGRHCDL EVDECVSDPC KNEATCLNEI GRYTCLCPHN YSGYTGAQCE SHVDTCSSNP
CLPDGECVEL SSEQGRLVQP LSPSSRPEAS GYICICPPGR TGIHCEEDLD ECSSSPCKNG
GTCENLTGNY TCRCLFDSHS GAFFGGRDCS DALLGCTDHP CLSSGLCIPH LRNGQHGFSC
LCPPGYTGSL CETVTTLSFE GNGFVWVPSG SVAAKDSGCD VALRFQTVQP TALLLFRGDG
DTFLALELLS GYVHVSVQVG HQPKVVLFIA QNASDGEWHS VEVTFAEAVT VALRDDSCTG
SCISKAPSPF GSDRSACALQ NSFLGGLPEG TIRSLPVDTL PSTPSLVGCL QDIEIGSNPI
TPESISSGWS LNVKAGCVRK DWCESHPCHH RGRCLNLWLG YQCACYRPYQ GRNCRREYVA
GRFGQDDALG YAAFHLDKSY GEAFSLSLFV RTRRPTGLLV ALENSTFQYV RVWLERGRLA
MLTPGSPKLV VNFVLSDGNA HLITLKIKPK KIELQQSSQN LGFISAPTWK LQRGDGIYVG
GLPDRQETEA SGGFFKGCIQ DIRLNNEHLE FFPNSTSRAA HSAVLVNVSQ GCPGDNMCEA
TPCHNGGVCY SLWDDFFCSC PAHTAGKACD EVRWCELSPC PPSAQCQEVP RGFECIANAV
FTGQSSEIVF RSNGNITRDL TNITFGFRTR DANMTILQAE KEPEFLHVSI RESRLLFHLQ
SGNGVHMLSL ASLQPVNDGL WHHVTLSMTD PRAQASRWQM EVDHPAPLVT SAVAAGSLDF
LKDDIDIHVG GQATDNTQGL RGCLSTIDIS GIHLSYFENV PGFMNKPQEE QFLKISKNPV
VTGCLPFNAC NSNPCSHGGR CEDMYRSYHC TCPGGWSGTH CELDVDECLS NPCFHGNCSD
SVAAYHCTCE PGYTGVHCEA VTDNCQNHQC ANGATCISDD KGYSCHCPGN VTGTLCRRAS
SPSAVCGKEK NFTCYNGGNC TESQGELQCT CRPGFTGEWC ERDVDECASN PCLHGGQCHD
LPNKFQCVCD VAFAGARCEL DLAEDLLSEV FAAIGAVTLA LLLILFLAVV ASVVTANKRA
TQGSYSPSRQ EKDGSRVEMW SAMAPPAMER LI
//
