ID A0A287A597_PIG Unreviewed; 855 AA.
AC A0A287A597;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 3.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Leucine rich repeats and death domain containing 1 {ECO:0000313|Ensembl:ENSSSCP00000039119.3};
GN Name=LRRD1 {ECO:0000313|Ensembl:ENSSSCP00000039119.3,
GN ECO:0000313|VGNC:VGNC:98090};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000039119.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000039119.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000039119.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000039119.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A287A597; -.
DR STRING; 9823.ENSSSCP00000039119; -.
DR PaxDb; 9823-ENSSSCP00000019733; -.
DR Ensembl; ENSSSCT00000048489.3; ENSSSCP00000039119.3; ENSSSCG00000029092.4.
DR VGNC; VGNC:98090; LRRD1.
DR GeneTree; ENSGT00940000161427; -.
DR InParanoid; A0A287A597; -.
DR Proteomes; UP000008227; Chromosome 9.
DR Bgee; ENSSSCG00000029092; Expressed in testis and 36 other cell types or tissues.
DR ExpressionAtlas; A0A287A597; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR CDD; cd01670; Death; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 6.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF1; ZGC:77287; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF00560; LRR_1; 2.
DR Pfam; PF12799; LRR_4; 1.
DR Pfam; PF13855; LRR_8; 4.
DR SMART; SM00364; LRR_BAC; 11.
DR SMART; SM00365; LRR_SD22; 10.
DR SMART; SM00369; LRR_TYP; 15.
DR SUPFAM; SSF52058; L domain-like; 2.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51450; LRR; 8.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 778..847
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 1..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..84
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 855 AA; 97426 MW; 557E14974B4D6797 CRC64;
MSEKESTPEE IEDVTSQLRE ESTSWSVEES GFIKESSSSL KEASDGTPSN QISEMRPRKN
MLGIHDDTST SSSGSKAKRF SEIITRPDSL QSKTEISPSS SLSITGMTAE YQAFLETLEK
ISPQLSEESQ KGFALGLDNF TVNLKAKGLQ EFPKDILKTN YVKYLNLDEN KIKSFKGVDP
SDLLGLEILS MKENGLSSLP SEIQLLHNLK TLNVSHNQIS HIPKELSQLG NIRQLFLNNN
CIEGSPSGLE SLGNLEILNL AKNKLRHIPD TLSSLKKLRG LNLEYNQLTI FPKALCFLPK
LISLNLTGNL ISSLPKEIKE LKNLEKLLLD HNKLTFLAVE IFRLLRMKEL QLTDNKLEVI
SHKIENFREL RILVLDKNLL KDVPENISHC VMLEFLSLSD NKLTELPKNI HKLKNLRKLH
INRNNIIKIP EDISHLNNMF SLEFAGNIIT DFPIEIKNCR KITKVELSYN KIIYFPLGLC
ALESLYYLSF NGNYISEIPE DISFSKQLLH LEFNENKLLI FSEHLCSLIN LEYLDLGKNK
IKKIPPSISN MVSLHVLILC CNKLETFPIE VCTLENLQVL DLSENQIQNI PPEICNLKGI
QKLNISSNQF IYFPIELCQL QSLEELNISQ INGRKLTRLP EELCNMIQLK ELDISNNAIR
EMPRSIGELR SLVSLKAYNN QIRYLPPSFL SLNALQQLNL SGNNLTALPS GIYNLFSLKE
INFDDNPLLR PPMEICKGKQ LYTIARYLQR ADERDEKILE KIFKIVATNI TETNFEFLCQ
KLNLTISETD KSTMSTVSLR EKVHQLLDRW KMENNLSVTA AALRDQLTRA LTMIGAYEIM
DKITALKLFT RAIKF
//
