ID A0A287A6Q2_PIG Unreviewed; 699 AA.
AC A0A287A6Q2;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Histone-lysine N-methyltransferase SETDB2 {ECO:0000256|ARBA:ARBA00040299};
DE EC=2.1.1.366 {ECO:0000256|ARBA:ARBA00039052};
DE AltName: Full=SET domain bifurcated 2 {ECO:0000256|ARBA:ARBA00042995};
GN Name=SETDB2 {ECO:0000313|Ensembl:ENSSSCP00000039625.2,
GN ECO:0000313|VGNC:VGNC:92765};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000039625.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000039625.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000039625.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000039625.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-
CC methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3]
CC + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60288, Rhea:RHEA-
CC COMP:15538, Rhea:RHEA-COMP:15541, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961,
CC ChEBI:CHEBI:61976; EC=2.1.1.366;
CC Evidence={ECO:0000256|ARBA:ARBA00036635};
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A287A6Q2; -.
DR Ensembl; ENSSSCT00000050377.3; ENSSSCP00000039625.2; ENSSSCG00000009395.5.
DR VGNC; VGNC:92765; SETDB2.
DR GeneTree; ENSGT00940000158209; -.
DR Proteomes; UP000008227; Chromosome 11.
DR Bgee; ENSSSCG00000009395; Expressed in mesenteric lymph node and 44 other cell types or tissues.
DR ExpressionAtlas; A0A287A6Q2; baseline and differential.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0140938; F:histone H3 methyltransferase activity; IEA:UniProt.
DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:UniProt.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR CDD; cd01395; HMT_MBD; 1.
DR CDD; cd10523; SET_SETDB2; 1.
DR Gene3D; 2.170.270.10; SET domain; 2.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR007728; Pre-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR047232; SETDB1/2-like_MBD.
DR PANTHER; PTHR46024; HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS; 1.
DR PANTHER; PTHR46024:SF3; HISTONE-LYSINE N-METHYLTRANSFERASE SETDB2; 1.
DR Pfam; PF01429; MBD; 1.
DR Pfam; PF05033; Pre-SET; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00391; MBD; 1.
DR SMART; SM00468; PreSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50982; MBD; 1.
DR PROSITE; PS50867; PRE_SET; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Cell cycle {ECO:0000256|ARBA:ARBA00022776};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT DOMAIN 144..216
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT DOMAIN 278..351
FT /note="Pre-SET"
FT /evidence="ECO:0000259|PROSITE:PS50867"
FT DOMAIN 354..674
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 72..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 555..586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..106
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 555..571
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 699 AA; 79923 MW; 5388AFD134041DB9 CRC64;
NEKSSDAKTF WMELEDDGKV DFIFEQVQSV LQSLKQKIKD GSATNKEYIQ AMILVNEATI
NSSSTLIKDH TSVTQNAQEN KSSSWPSTSY KDSFPENLTP LSAENKETPP LENKVADFRE
EESSSKLSYQ RHDCSGACLM KMPLTFKGEN PLQLPIKCHF QRRHAKTNSH SSALHVSYKT
PCGRSLRNVE EVFRYLLETE CNFLFTDNFS FNTYVQLTRN YPKQEEIVSD VDISNGVESV
PISFCNEIDN RKLPQFKYRK TMWPRTYYLN SFPNMFIDSC DCSEGCIDIT KCACLQLTAR
NAKTCPLSSS KITTGYKYKR LQRQIPTGIY ECSLLCKCNR RKCQNRVVQH GPQVRLQVFK
TEKKGWGVRC LDDIDRGTFV CIYSGRLLSR SNTEKPDATD ENRKEEIFMK NMFSKKRKIE
VADCEVEVIP LDLETHPRSS VTEECPPKLH NNPKEPFTEM KCNSISRIQY HSVIRSPQTK
TVIIQRNGKK MGFSSSESLT SEDNGGFKST QVHLNSPAKE MRMDSSSNQV EDSKANPLIE
LDVIDITKCR EETPQGSRYN QAVTLDNPNE VQKQKPQEKK SPACQNQQAF CDKEIPSETK
NASPDSPKKF NKGSMFLLDA TKEGNVGRFL NHSCCPNLLV QNVFVETHDR NFPLVAFFTN
RYVKARTELT WDYGYEAGTM PEKEILCQCG VNKCRKKIL
//
