ID A0A287AFL5_PIG Unreviewed; 1456 AA.
AC A0A287AFL5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 2.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Myosin-binding protein C, cardiac-type {ECO:0000256|ARBA:ARBA00044086};
DE AltName: Full=C-protein, cardiac muscle isoform {ECO:0000256|ARBA:ARBA00044215};
GN Name=MYBPC3 {ECO:0000313|Ensembl:ENSSSCP00000042773.2,
GN ECO:0000313|VGNC:VGNC:90501};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000042773.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000042773.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000042773.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000042773.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. MyBP family.
CC {ECO:0000256|ARBA:ARBA00038352}.
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DR Ensembl; ENSSSCT00000039375.3; ENSSSCP00000042773.2; ENSSSCG00000013236.5.
DR VGNC; VGNC:90501; MYBPC3.
DR GeneTree; ENSGT00940000157698; -.
DR Proteomes; UP000008227; Chromosome 2.
DR Bgee; ENSSSCG00000013236; Expressed in heart left ventricle and 19 other cell types or tissues.
DR ExpressionAtlas; A0A287AFL5; baseline and differential.
DR CDD; cd00063; FN3; 3.
DR CDD; cd00096; Ig; 1.
DR CDD; cd05894; Ig_C5_MyBP-C; 1.
DR CDD; cd05748; Ig_Titin_like; 1.
DR CDD; cd20962; IgI_C1_MyBP-C_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 12.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR040849; MyBP-C_THB.
DR PANTHER; PTHR13817:SF20; MYOSIN-BINDING PROTEIN C, CARDIAC-TYPE; 1.
DR PANTHER; PTHR13817; TITIN; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF07679; I-set; 7.
DR Pfam; PF18362; THB; 1.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 8.
DR SMART; SM00408; IGc2; 4.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 8.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 4.
PE 1: Evidence at protein level;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Muscle protein {ECO:0000256|ARBA:ARBA00023179};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A287AFL5};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Thick filament {ECO:0000256|ARBA:ARBA00022433}.
FT DOMAIN 604..677
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 825..947
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 956..1052
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1054..1149
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1153..1241
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1250..1345
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1363..1451
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 175..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1456 AA; 159976 MW; 28C1F000D8256090 CRC64;
MGEGPGASQA QWGPTFSWRA LDLWNLSIFS RWLGRVQIRR AWGGGSPLYS RGTGACSDSL
WGACACSVPG DLSEMPEPGK KPVSAFSKKP RSVEVAAGSP AVFEAETERA GVKVRWQRAG
SDISPSDKYG LAVEGTRHTL TVRDVGPADQ GSYAVIAGSS KVKFDLKVLE AGKAEPVPGP
ASAPTEAPGA PGEALASATE VEGGSPSPEG SSSAAPDGPS APDDPIGLFV MRPQDGEVTV
GGSITFSARV AGASLLKPPV VKWFKGKWVD LSSKVGQHLQ LHDTYDRASK VYLFELHITD
AQTTFAGGYR CEVSTKDKFD SCNFNLIVHE AIGPGDLDLR STFRRTSLAG GGRRISDSHE
DAGTLDFSSL LRKSSFRTPR DPKLEAPVEE DVWEILRHAP PSEYERIAFQ HGITDLRGML
KRLKGIKRDE KKSTAFQKKL QPAYQVSKGH KIRLMVELAD PDAEVKWLKN GQEIQMSGRC
GGSRASSGDA GEAGLLPTHL PCLSTHALLV RPALIPSLHL LPFLSQCNSP SFCFFPAPPL
LIFCGSHFLP SDQWPLLLHS KYIFESIGTK RMLTISQCSL ADDAAYQCVV GGEKCSTELF
VKEPPVLITR PLEDQLVMVG QRVEFECEVS EEGAQVKWLK DGVELTREET FKYRFKKDGQ
KHHLIINEAT LEDAGHYALH TSGGQALAEL IVQEKKLEVY QSIADLTVGA KDQAVFKCEV
SDENVRGVWL KNGKELVPDS RIKVSHIGRV HKLTIDDVTP ADEADYSFVP EGFACNLSAK
LHFMGEEVLW GMGPLSLGPA FTVVPIALPS LAEVKIDFVP RQEPPKIHLD CPGRKPDTIV
VVAGNKLRLD VPISGDPAPT VIWQKTITKG NKIPAGPAPD ADAAGDSGAS DEWVFDRKLL
CETEGRVRVE TTKDRSIFTV EGAEKEDEGV YVVTVKNPVG EDQVNLTVKV IDVPDAPAAP
KISNVGEDSC TVQWEPPAYD GGQPVLGYIL ERKKKKSYRW MRLNFDLLRE LSLEARRMIE
GVVYEMRVYA VNAVGMSRPS PASQPFMPIG PPSEPTHLAV EDVSDTTVSL KWRPPERVGA
GGLDGYSLEY CREGCSEWVD ALQGLTERTT MLVKDLPTGA RLLFRVRAHN VAGPGAPVTT
KEPVTVQEIL QRPRLQLPRH LRQTIQRKVG EPVNLLIPFQ GKPRPQVTWT KEGQPLAGEE
VSIRNSPTDT ILFIRAARRA HSGTYQVTLR IENMEDKAEL VLQVIDKPSP PQDIRVIETW
GFNVALEWKP PQDDGNTELW GYTVQKADKR TMEWFTVLEH YRRTHCVVSE LVIGNGYYFR
VFSHNTVGPS DRASTTKEPV FIPRPAIKYE PPSYKALDFS EAPSFTRPLV NRSVIAGYNT
TLCCAVRGSP KPQISWFKNG LDLGKDARFR MFSKQGVLTL EIRKPCPFDG GVYVCRATNL
QGEAQCECRL EVRGEE
//
