ID A0A287AFP2_PIG Unreviewed; 782 AA.
AC A0A287AFP2;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Zinc finger protein 41 {ECO:0000313|EMBL:HDC05215.1, ECO:0000313|Ensembl:ENSSSCP00000032213.1};
GN Name=ZNF41 {ECO:0000313|Ensembl:ENSSSCP00000032213.1};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|EMBL:HDC05215.1};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000032213.1, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000032213.1,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HDC05215.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000032213.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; DQIR01249737; HDC05215.1; -; Transcribed_RNA.
DR STRING; 9823.ENSSSCP00000032213; -.
DR Ensembl; ENSSSCT00000046814.2; ENSSSCP00000032213.1; ENSSSCG00000039997.3.
DR GeneTree; ENSGT00940000163107; -.
DR Proteomes; UP000008227; Chromosome X.
DR Bgee; ENSSSCG00000039997; Expressed in mesenteric lymph node and 42 other cell types or tissues.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0001817; P:regulation of cytokine production; IBA:GO_Central.
DR GO; GO:0002682; P:regulation of immune system process; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 17.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24393; ZINC FINGER PROTEIN; 1.
DR PANTHER; PTHR24393:SF88; ZINC FINGER PROTEIN 485; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 16.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 18.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 10.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 17.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 18.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 27..98
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 244..273
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 274..301
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 330..357
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 358..385
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 386..413
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 414..441
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 442..469
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 470..497
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 498..525
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 526..553
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 554..581
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 582..609
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 610..637
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 638..665
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 666..693
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 694..721
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 722..749
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 750..777
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
SQ SEQUENCE 782 AA; 90184 MW; E577619966CFF116 CRC64;
MPTNRSSPQW SPTRTAVGHG SMCEASVSFE DVTVDFSREE WQHLDPAQRR LYRDVTLENY
SHLRSVGYHV PKPEVICKLE QGEGPWTLEE ETPHQSYSDE NIGQTQQQRI SGEVSFHCEK
FGQSIGKDSL CSILELWQDN DQLERYQENG NNPLSHMKVL IKERGYEYKN IEKIIHVSSR
HVPSIKRLRN CDTFGKNLKH TLNLHNHNKS NATKNFDKIF ENGNNFAHSS SSTKNENAAN
TRANSCELNR CEKHLGHKQI LTHHQKIHTG EKLYECAEYV KTLTQKSHLF EHQRIHAGEK
SHECNKSENI FTQKPQIEVP QSVYTREKPF ICAQCGKAFT LRSNLITHQK IHTGQKPYKC
SECGKAFFHR SYLFRHMRIH TGEKPYECSE CGRGFSQNSD LNIHQKTHTG EKHYACSECG
KAFTRKSALR MHQRIHTGEK PYVCTECGKA FIQKSHFNTH QRIHTGEKPY ECSDCGKSFI
KKSQLHVHQR IHTGEKPYIC TECGKVFTHR TNLTTHQKTH TGEKPYMCAE CGKAFSDQSN
LIKHQKTHTG EKPYKCNGCG KAFIWKSRLK IHQKSHIGER HYECNECGKA FIQKSTLSVH
QRIHTGEKPY ACPECGKAFI QKSHFIAHHR IHTGEKPYEC SDCGKCFTKK SQLRVHQKIH
TGEKPNICAE CGKAFTDRSN LITHQKIHTR EKPYKCSDCG KTFTWKSRLT IHQKSHTGER
HYECSKCGKA FIQKATLSMH QIIHTGKKPY ACTECQKAFT DRSNLIKHQK THSGEKLYKA
SD
//
