ID A0A287AG11_PIG Unreviewed; 566 AA.
AC A0A287AG11;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Fibroblast growth factor receptor like 1 {ECO:0000313|Ensembl:ENSSSCP00000042909.2};
GN Name=FGFRL1 {ECO:0000313|Ensembl:ENSSSCP00000042909.2,
GN ECO:0000313|VGNC:VGNC:88121};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000042909.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000042909.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000042909.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000042909.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A287AG11; -.
DR SMR; A0A287AG11; -.
DR STRING; 9823.ENSSSCP00000042909; -.
DR Ensembl; ENSSSCT00000059244.3; ENSSSCP00000042909.2; ENSSSCG00000036512.3.
DR VGNC; VGNC:88121; FGFRL1.
DR GeneTree; ENSGT00940000156736; -.
DR InParanoid; A0A287AG11; -.
DR Reactome; R-SSC-5658623; FGFRL1 modulation of FGFR1 signaling.
DR Proteomes; UP000008227; Chromosome 8.
DR Bgee; ENSSSCG00000036512; Expressed in subcutaneous adipose tissue and 34 other cell types or tissues.
DR ExpressionAtlas; A0A287AG11; baseline and differential.
DR GO; GO:0044291; C:cell-cell contact zone; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0030133; C:transport vesicle; IEA:Ensembl.
DR GO; GO:0017134; F:fibroblast growth factor binding; IBA:GO_Central.
DR GO; GO:0005007; F:fibroblast growth factor receptor activity; IBA:GO_Central.
DR GO; GO:0008201; F:heparin binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0098742; P:cell-cell adhesion via plasma-membrane adhesion molecules; IEA:Ensembl.
DR GO; GO:0060539; P:diaphragm development; IEA:Ensembl.
DR GO; GO:0003179; P:heart valve morphogenesis; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0001501; P:skeletal system development; IEA:Ensembl.
DR GO; GO:0060412; P:ventricular septum morphogenesis; IEA:Ensembl.
DR CDD; cd05856; IgI_2_FGFRL1-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR19890; FIBROBLAST GROWTH FACTOR RECEPTOR; 1.
DR PANTHER; PTHR19890:SF10; FIBROBLAST GROWTH FACTOR RECEPTOR-LIKE 1; 1.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 1.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 432..455
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 86..172
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 204..294
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 303..411
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 176..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 465..566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 538..566
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 566 AA; 61072 MW; B790FC978C5ECD43 CRC64;
MPAACPLTPG PGILLPNLGW PGWQEGSPCP GSRPGSMQSI RTHRQARTGP ANTGTQAHRH
TWTTSCLQGA GRGCPRLPVD MGPGPPRMAD KVVPRQVARL GRTVRLQCPV EGDPPPLTMW
TKDGRTIHGG WSRFRVLPQG LKVKEVERED AGAYVCKATN GFGSLSVNYT LIVMDDTSPG
RESPGLDGPS GGQEDPASKQ WARPRFTQPS KMRRRVIARP VGSSVRLKCV ASGHPRPDIM
WMKDDQALTR PEAGEHRKKK WTLSLKNLRP EDSGKYTCRV SNRAGAINAT YKVDVIQRTR
SKPVLTGTHP VNTTVDFGGT TSFQCKVRSD VKPVIQWLKR VEYGAEGRYN STIDVGGQKF
VVLPTGDVWS RPDGSYLNKL LITRARQDDA GMYICLGANT MGYSFRSAFL TVLPDPKPPG
PPVVPSSSST SLPWPVVIGI PAGAVFILGT VLLWLCQAKK KPCAPAPAAP MPVHRPPVVA
RDRDRGGGGG DKDLPAPTAL GTGPGVGLCE DLGPPAPPQH LLGPGSAAGP KLYPKLYTDT
HTHTHTHSHT HSHVEGKVHQ HVHYQC
//
