ID A0A287AGJ6_PIG Unreviewed; 178 AA.
AC A0A287AGJ6;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Troponin I, fast skeletal muscle {ECO:0000256|ARBA:ARBA00039349};
DE AltName: Full=Troponin I, fast-twitch isoform {ECO:0000256|ARBA:ARBA00042462};
GN Name=TNNI2 {ECO:0000313|Ensembl:ENSSSCP00000042975.1,
GN ECO:0000313|VGNC:VGNC:94283};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000042975.1, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000042975.1, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000042975.1,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000042975.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Troponin I is the inhibitory subunit of troponin, the thin
CC filament regulatory complex which confers calcium-sensitivity to
CC striated muscle actomyosin ATPase activity.
CC {ECO:0000256|ARBA:ARBA00001988}.
CC -!- SUBUNIT: Binds to actin and tropomyosin.
CC {ECO:0000256|ARBA:ARBA00038767}.
CC -!- SIMILARITY: Belongs to the troponin I family.
CC {ECO:0000256|ARBA:ARBA00009930}.
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DR AlphaFoldDB; A0A287AGJ6; -.
DR SMR; A0A287AGJ6; -.
DR Ensembl; ENSSSCT00000049867.1; ENSSSCP00000042975.1; ENSSSCG00000033260.3.
DR VGNC; VGNC:94283; TNNI2.
DR GeneTree; ENSGT01030000234588; -.
DR OMA; KRHRAIT; -.
DR Proteomes; UP000008227; Chromosome 2.
DR Bgee; ENSSSCG00000033260; Expressed in longissimus lumborum muscle and 29 other cell types or tissues.
DR ExpressionAtlas; A0A287AGJ6; baseline and differential.
DR GO; GO:0005861; C:troponin complex; IEA:InterPro.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.350; -; 1.
DR Gene3D; 6.10.250.180; -; 1.
DR InterPro; IPR001978; Troponin.
DR InterPro; IPR038077; Troponin_sf.
DR PANTHER; PTHR13738; TROPONIN I; 1.
DR PANTHER; PTHR13738:SF15; TROPONIN I, FAST SKELETAL MUSCLE; 1.
DR Pfam; PF00992; Troponin; 1.
DR SUPFAM; SSF90250; Troponin coil-coiled subunits; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Muscle protein {ECO:0000256|ARBA:ARBA00023179};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT COILED 23..102
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 178 AA; 20900 MW; 02CC5E0DC9208449 CRC64;
QKRHRAITAR RQHLKSVMLQ IAATELEKEV GRRESEKQNY LSEHCPPLHL PGSMSEVQEL
CKQLHAKIDA AEEEKYDMEI KVQKSTKELE DMNQKLFDLR GKFKRPPLRR VRMSADAMLK
ALLGSKHKVC MDLRANLKQV KKEDTEKERD LRDVGDWRKN IEEKSGMEGR KKMFETES
//
