ID A0A287AH94_PIG Unreviewed; 964 AA.
AC A0A287AH94;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 2.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=SH3 domain binding protein 4 {ECO:0000313|Ensembl:ENSSSCP00000043278.2};
GN Name=SH3BP4 {ECO:0000313|Ensembl:ENSSSCP00000043278.2,
GN ECO:0000313|VGNC:VGNC:95495};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000043278.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000043278.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000043278.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000043278.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, clathrin-coated vesicle
CC {ECO:0000256|ARBA:ARBA00004132}. Membrane, clathrin-coated pit
CC {ECO:0000256|ARBA:ARBA00004600}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}. Vesicle
CC {ECO:0000256|ARBA:ARBA00004373}.
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DR AlphaFoldDB; A0A287AH94; -.
DR STRING; 9823.ENSSSCP00000043278; -.
DR Ensembl; ENSSSCT00000037439.3; ENSSSCP00000043278.2; ENSSSCG00000034692.3.
DR VGNC; VGNC:95495; SH3BP4.
DR GeneTree; ENSGT00390000013151; -.
DR InParanoid; A0A287AH94; -.
DR OMA; HRIRANN; -.
DR Reactome; R-SSC-9639288; Amino acids regulate mTORC1.
DR Proteomes; UP000008227; Chromosome 15.
DR Bgee; ENSSSCG00000034692; Expressed in endocardial endothelium and 37 other cell types or tissues.
DR ExpressionAtlas; A0A287AH94; baseline and differential.
DR GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
DR GO; GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005092; F:GDP-dissociation inhibitor activity; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0071230; P:cellular response to amino acid stimulus; IEA:Ensembl.
DR GO; GO:0030308; P:negative regulation of cell growth; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0032007; P:negative regulation of TOR signaling; IEA:Ensembl.
DR GO; GO:0010508; P:positive regulation of autophagy; IEA:Ensembl.
DR GO; GO:0061462; P:protein localization to lysosome; IEA:Ensembl.
DR CDD; cd11757; SH3_SH3BP4; 1.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR035456; SH3BP4_SH3.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR15603:SF3; SH3 DOMAIN-BINDING PROTEIN 4; 1.
DR PANTHER; PTHR15603; SH3 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF00791; ZU5; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 2.
DR PROSITE; PS51145; ZU5; 1.
PE 4: Predicted;
KW Coated pit {ECO:0000256|ARBA:ARBA00023176};
KW Membrane {ECO:0000256|ARBA:ARBA00023176};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 55..114
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 318..455
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 655..725
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
SQ SEQUENCE 964 AA; 106688 MW; DC9EB82A2673B8AD CRC64;
MAAQRIRAAN SSGLPRCKSE GTLIDLSEGF SETSFNDVKV PSPSALLADN PTPFGNAKEV
IAIKDYCPTN FTTLKFSKGD HLYVLDTSGG EWWYAHNTTE MGYIPSSYVQ PLNYRNSTLS
DSGMIDNLPD SPDEVAKALD LLGGWAEDKK GSSKPSSNNP FWNGVQTNPF LNGNVPAVMP
SVDALTPKST VDLLLFDAGP SSFTESGSAT TSSTGNVFDE LPATGRLHAE PPVKRDNPFF
RSKRSYSLSE LSVLQAKSDA PASSGFFSGL KSPAPEQFQS REDFRAAWLS HRKLARSCHD
LDLLGQSPGW GQTQAVETNI VCKLDSSGGS VQLPDTAISI HVPEGHVAPG ETQQISMKAL
LDPPLELNSD RCSSISPVLE VKLSTLEVNT HVVLEMKVSA EVKSDVFSKS TVGLQCLRSD
AKEGPYVPIP LSYSYGDTVQ VQLDNLEPCM YLAVVAHGPN ILYPSTVWDF IHKKVTVGLY
GPKHIHPSFK TVVTIFGHDC APKTLLVSEV TRQAPGPAPV ALQLWGKHQF VLSRPQDLQV
CMFSNMTNYE VKASEQAKAV RGFQVKLGKV SRLIFPIICQ NPGELSDFTL RVQVKDDQEA
ILTQFCVQTP QPPPKSAIKP SGQRRFLKKN EVGKIILSPF AATTKYPTFQ DRPVSSLKFG
KLLKTVVRQS KNHYLLEYKK GDAIALLSEE KIRLKGQLWT KEWYIGYHQG KVGLVHAKNV
LVVGRARPSP LAGPELSTSA LLEQILRPCK FLTYIYASVR TLLMENIGSW RSFADALGYG
NLPLTFFCRA ELDSEPERVA SVLEKLKEDC NNADNKERKS FQKELMMALL KMDCQGLVVR
LIQDFVLLTT AVEVAQRWRE LAEKLAKVSK QQMDAYESPH RDRNGVVDSE AMWKPAYDFL
LTWSHQIGDS YRDVIQELHT GLDKMKNPIT KRWKHLTGTL ILVNSLDVLR AAAFSPMDQD
DYVI
//
