ID A0A287AIX7_PIG Unreviewed; 1207 AA.
AC A0A287AIX7;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Patched 2 {ECO:0000313|Ensembl:ENSSSCP00000043845.2};
GN Name=PTCH2 {ECO:0000313|Ensembl:ENSSSCP00000043845.2,
GN ECO:0000313|VGNC:VGNC:91941};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000043845.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000043845.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000043845.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000043845.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
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DR AlphaFoldDB; A0A287AIX7; -.
DR SMR; A0A287AIX7; -.
DR STRING; 9823.ENSSSCP00000043845; -.
DR Ensembl; ENSSSCT00000046917.2; ENSSSCP00000043845.2; ENSSSCG00000031977.2.
DR VGNC; VGNC:91941; PTCH2.
DR GeneTree; ENSGT00940000159901; -.
DR InParanoid; A0A287AIX7; -.
DR Proteomes; UP000008227; Chromosome 6.
DR Bgee; ENSSSCG00000031977; Expressed in oocyte and 27 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0097108; F:hedgehog family protein binding; IBA:GO_Central.
DR GO; GO:0008158; F:hedgehog receptor activity; IBA:GO_Central.
DR GO; GO:0005119; F:smoothened binding; IBA:GO_Central.
DR GO; GO:0001709; P:cell fate determination; IEA:Ensembl.
DR GO; GO:0009957; P:epidermal cell fate specification; IEA:Ensembl.
DR GO; GO:0042633; P:hair cycle; IEA:Ensembl.
DR GO; GO:0045879; P:negative regulation of smoothened signaling pathway; IBA:GO_Central.
DR GO; GO:0045606; P:positive regulation of epidermal cell differentiation; IEA:Ensembl.
DR GO; GO:0001558; P:regulation of cell growth; IEA:Ensembl.
DR GO; GO:0043588; P:skin development; IEA:Ensembl.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR InterPro; IPR004766; TM_rcpt_patched.
DR NCBIfam; TIGR00918; 2A060602; 1.
DR PANTHER; PTHR46022; PROTEIN PATCHED; 1.
DR PANTHER; PTHR46022:SF3; PROTEIN PATCHED HOMOLOG 2; 1.
DR Pfam; PF02460; Patched; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 399..416
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 428..451
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 457..478
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 499..521
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 527..552
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 964..984
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 991..1010
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1016..1041
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1062..1081
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1087..1114
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 394..552
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 1184..1207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1188..1207
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1207 AA; 130093 MW; DA8EAE57BEA9AB51 CRC64;
MAGPPPLGEL PPGYASPDGS AAPQILAGSL KAPLWLRASF QGLLFSLGCA VQRHCGKVLF
LGLLAFGALA LGLRVAVIET DLEQLWVEAG SRVSQELQYT KEKLGEEAAY TSQMLIQTPR
QEGENVLTPE ALGLHLQAAL TASKVQVSLY GKSWDLNKIC YKSGVPLIEN GMIERMVEKL
FPCVILTPLD CFWEGAKLQG GSAYLPGRPD IQWTNLDPEH LLEELGPFAS LEGFRELLDK
AQVGQAYVGR PCLHPDDLHC PPSAPNHHSR QAPNVAQELS GGCHGFSHKF MHWQEELLLG
GMARDPQGQL LRAEALQSTF LLMSPRQLYE HFRGDYQTHD IGWSEEQAGT VLQAWQRRFV
QLAQEALPGN ASQQIHAFSA ATLDDILHAF SEVSATRVVG GYLLMLAYAC VTMLRWDCAQ
SQGAVGLAGV LLVALAVASG LGLCALLGIA FNAATTQVLP FLALGIGVDD IFLLAHAFTE
APPGTPLQER TGECLQRTGT SVALTSINNM VAFFMAALVP IPALRAFSLQ AAIVVGCNFA
AVMLVFPAVL SLDLHRRHCQ RLDVLCCFAS PCSARVIQIL PQELGDGTVP VGIARLTATV
QAFAHCEASS QHVVTILPPQ THLVPPPSDP LGSELFSPGG STRDLLGQEE GTRQKAACKS
LSCAHWNLAH FARSQFAPLL LQPHAKAMVL VLFGALLGLS LYGATLVQDG LALTDVVPRG
TKEHAFLSAQ LRYFSLYEVA LVTQGGFDYA HSQRALFDLH QRFSSLKAVL PPPATQAPRT
WLHYYRNWLQ EIQAAFDQDW ASGRITRHSY RNGSEDGALA YKLLIQTGDA QEPLDFSQLT
TRKLVDQEGL IPPELFYVGL TVWVSSDPLG LAAAQANFYP PPPEWLHDKY DTTGENLRIP
AAQPLEFAQF PFLLRGLQKT ADFVEAIEGA RAACAEAGRA GVRAYPSGSP FLFWEQYLGL
RRCFLLAICL LLAGTFFVCA LLLLSPWTAA LIVLVLAMMT VELFGIMGFL GIKLSAIPVV
ILVASVGIGV EFTVHVALGF LTAQGSQNLR AARALEHTFA PVTDGAVSTL LGLLMLAGSN
FDFIVRYFFV VLTVLALLGL LHGLVLLPVL LSILGPPPEV VQMYKESPEV TSPPAPRAGG
LRWELPPTLP ESFARVTTSM TVALRPPPLP GAYIHAASEE PAWSPAATPA ASGSSNLSSR
GPCAATG
//
