ID A0A287AJ01_PIG Unreviewed; 2060 AA.
AC A0A287AJ01;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Dedicator of cytokinesis 9 {ECO:0000313|Ensembl:ENSSSCP00000043869.2};
GN Name=DOCK9 {ECO:0000313|Ensembl:ENSSSCP00000043869.2,
GN ECO:0000313|VGNC:VGNC:87399};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000043869.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000043869.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000043869.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000043869.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR Ensembl; ENSSSCT00000065653.2; ENSSSCP00000043869.2; ENSSSCG00000022112.4.
DR VGNC; VGNC:87399; DOCK9.
DR GeneTree; ENSGT00940000155972; -.
DR Proteomes; UP000008227; Chromosome 11.
DR ExpressionAtlas; A0A287AJ01; baseline and differential.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08697; C2_Dock-D; 1.
DR CDD; cd11698; DHR2_DOCK9; 1.
DR CDD; cd13267; PH_DOCK-D; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037809; C2_Dock-D.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF77; DEDICATOR OF CYTOKINESIS PROTEIN 9; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A287AJ01};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT DOMAIN 173..280
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 639..816
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1595..2022
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 289..311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1244..1285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1905..1932
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 289..305
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2060 AA; 234694 MW; 8DF870382907094C CRC64;
MQADKCRTSG RSVKKELVIE SPLQCKDAAQ GEVEAESPGP VPAKPKLIEP LDYENVIVQK
KTQILNDCLR EMLLFPYDDF QTAILRRQGR YLRSTVPAKA QEEAQSLFVT ECIKTYNSDW
HLVNYKYEDY SGEFRQLPNK VAKLDKLPVH VYEVDEEVDK DEDAASLGSQ KGGITKHGWL
YKGNVNSAIS VTMRSFKRRF FHLIQLGDGS YNLNFYKDEK ISKEPKGSIF LDSCMGVVQN
NKVRRFAFEL KMQDKSSYLL AADSEVEMEE WITTLNKILQ LNFEAAMQEK RNGDAHEDDD
QSRLEGSGSG LDSYLPELAK SAREAEIKLK SESRVKLFYL DPDAQKLDFS SAEPEVKPFE
EKFGKRILVK CNDLSFNLQC CVAENEEGPT TNVEPFFVTL SLFDIKYNRK ISADFHVDLN
HFSVRQMLAT TSPSVMNGGR QSSPALQDNP HEAAMQYPKQ GIFSVTCPHP DIFLVARIEK
VLQGSITHGA EPYMKSSDSS KVAQKVLKNA KQACQRLGQY RMPFAWAART LFKDASGNLD
KNARFSALYK QDSNKLSNED MLKFLADFRK PEKMAKLPVI LGNLDITIDN VSSDVPNYVN
SSYIPMKQFE TCAKTPITFE VEEFVPCIPR HTQPHTIYNN HLYVYPKYLK YDSQKTFAKA
RNIAICIEFK DSDEEDSLPL KCIYGRPGGP LFTRSAFAAV LHHHQNPEFY DEIKIELPTQ
LHEKHHLLFT FFHVSCDNSS KGSTKKKDVE TQVGYSWLPL LKDGRVVTSE QHIPVSANLP
PGYLGYQELG MGRHHGPEIK WVDGSKPLLK VSTHLVSTVY TQDQHLHNFF QYCQKTESGA
QALGSELVKY LKSLHAMEGH VMIAFLPTIL NQLFRVLTRA TQEEVAVNVT RVIIHVVAQC
HEEGLESHLR SYVKYAYKAE PYVASEYKTV HEELTKTMTT ILKPSADFLT SNKLLKYSWF
FFEVLIKSMA QHLIENSKVK LLRNQRFPAS YHHAVETVVN MLMPHITQKF RDNPEASKNA
NHSLAVFIKR CFTFMDRGFV FKQINNYISC FAPGDPKVRA QVVFCVCVCV CVYTMCACLP
RPFSVMSFLT DVISVLISDL QLDYALTDEF CRNHFLVGLL LREVGTALQE FREVRLIAIS
VLKNLLIKHS FDDRYASRSH QARIATLYLP LFGLLIENVQ RINVRDVSPF PVNPGSTVKE
ESLALPAVNP LVTPQKSGAT LDASLHKDLF GAISGIASPY TNSTPNINSV RNADSRGSLI
STDSGNSLPE RNSEKSNSLD KHQQGGTLGN SVVRCDKLDQ SEIKNLLMCF LYILKSMSDD
ALFTYWNKAS TSELMDFFTI SEVCLHQFQY MGKRYIARYR GGLSLRSRYG HSDADVLHQS
LLEANIATEV CLTALDTLSL FTLAFKNQLL ADHGHNPLMK KVFDVYLCFL QKHQSETALK
NVFTALRSLI YKFPSTFYEG RADMCSALCY EILKYCNSKL SAIRTEASQL LYFLMRNNFD
YTGKKSFVRT HLQVIISVSQ LIADVVGIGG TRFQQSLSII NNCANSDRLI KHTTFSSDVK
DLTKRIRTVL MATAQMKEHE NDPEMLVDLQ YSLAKSYAST PELRKTWLDS MARIHVKNGD
LSEAAMCYVH VTALVAEYLT RKGVFRQGCT AFRVITPNID EEASMMEDVG MQDVHFNEDV
LMELLEQCAD GLWKAERYEL IADIYKLIIP IYEKRRDFER LAHLYDTLHR AYSKVTEVMH
SGRRLLGTYF RVAFFGQGFF EDEDGKEYIY KEPKLTPLSE ISQRLLKLYS DKFGSENVKM
IQDSGKVNPK DLDSKYAYIQ VTHVVPFFDE KELQERKTEF ERSHNIRRFM FEMPFTQTGK
RQGGVEEQCK RRTILTAIHC FPYVKKRIPV MYQHHTDLNP IEVAIDEMSK KVAELRQLCA
SAEVDMIKLQ LKLQGSVSVQ VNAGPLAYAR AFLDDTNTKR YPDNKVKLLK EVFRQFVEAC
GQALAVNERL IKEDQLEYQE EMKANYREMA RELSEIMHEQ ICPLEEKTSV LPNSLHIFNA
ISGTPTSTMV HGMTSSSSVV
//
