ID A0A287AJD5_PIG Unreviewed; 382 AA.
AC A0A287AJD5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=G protein subunit alpha 12 {ECO:0000313|Ensembl:ENSSSCP00000076609.1};
GN Name=GNA12 {ECO:0000313|Ensembl:ENSSSCP00000076609.1};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000076609.1, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000076609.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000076609.1};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000076609.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the G-alpha family. G(12) subfamily.
CC {ECO:0000256|ARBA:ARBA00010405}.
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DR AlphaFoldDB; A0A287AJD5; -.
DR SMR; A0A287AJD5; -.
DR STRING; 9823.ENSSSCP00000043999; -.
DR PaxDb; 9823-ENSSSCP00000024668; -.
DR Ensembl; ENSSSCT00000098545.1; ENSSSCP00000076609.1; ENSSSCG00000055213.1.
DR GeneTree; ENSGT00940000157636; -.
DR InParanoid; A0A287AJD5; -.
DR OMA; FLEYCPA; -.
DR OrthoDB; 2897309at2759; -.
DR Reactome; R-SSC-416482; G alpha (12/13) signalling events.
DR Reactome; R-SSC-456926; Thrombin signalling through proteinase activated receptors (PARs).
DR Proteomes; UP000008227; Chromosome 3.
DR Bgee; ENSSSCG00000032549; Expressed in oocyte and 43 other cell types or tissues.
DR ExpressionAtlas; A0A287AJD5; baseline and differential.
DR GO; GO:0031526; C:brush border membrane; IBA:GO_Central.
DR GO; GO:0005834; C:heterotrimeric G-protein complex; IBA:GO_Central.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:Ensembl.
DR GO; GO:0043005; C:neuron projection; IEA:Ensembl.
DR GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR GO; GO:0031752; F:D5 dopamine receptor binding; IBA:GO_Central.
DR GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0051721; F:protein phosphatase 2A binding; IEA:Ensembl.
DR GO; GO:0019888; F:protein phosphatase regulator activity; IEA:Ensembl.
DR GO; GO:0007188; P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IEA:Ensembl.
DR GO; GO:0042733; P:embryonic digit morphogenesis; IEA:Ensembl.
DR GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
DR GO; GO:0008217; P:regulation of blood pressure; IEA:Ensembl.
DR GO; GO:0008360; P:regulation of cell shape; IEA:Ensembl.
DR GO; GO:0010762; P:regulation of fibroblast migration; IEA:Ensembl.
DR GO; GO:0032434; P:regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR GO; GO:0032006; P:regulation of TOR signaling; IEA:Ensembl.
DR GO; GO:0007266; P:Rho protein signal transduction; IBA:GO_Central.
DR CDD; cd00066; G-alpha; 1.
DR Gene3D; 1.10.400.10; GI Alpha 1, domain 2-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR000469; Gprotein_alpha_12/13.
DR InterPro; IPR001019; Gprotein_alpha_su.
DR InterPro; IPR011025; GproteinA_insert.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10218; GTP-BINDING PROTEIN ALPHA SUBUNIT; 1.
DR PANTHER; PTHR10218:SF130; GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-12; 1.
DR Pfam; PF00503; G-alpha; 1.
DR PRINTS; PR00318; GPROTEINA.
DR PRINTS; PR00440; GPROTEINA12.
DR SMART; SM00275; G_alpha; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47895; Transducin (alpha subunit), insertion domain; 1.
DR PROSITE; PS51882; G_ALPHA; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
SQ SEQUENCE 382 AA; 44168 MW; 9C61A3F685477B13 CRC64;
MSGVVRTLSR CLLPAEAGGA RERRAGGGGA RDAEREARRR SRDIDAGLAR ERRAVRRLVK
ILLLGAGESG KSTFLKQMRI IHGREFDQKA LLEFRDTIFD NILKGSRVLV DAREKLGIPW
QYSENEKHGM FLMAFESRAG LPVEPATFQL YVPALSALWR DSGIREAFSR RSEFQLGESV
KYFLDNLDRI GQLNYFPSKQ DILLARKATK GIVEHDFVIK KIPFKMVDVG GQRSQRQKWF
QCFDGITSIL FMVSSSEYDQ VLMEDRCTNR LVESMNIFET IVNNKLFFNV SIILFLNKMD
LLVEKVKAVS IKKHFPDFKG DPHRLEDVQR YLVQCFDRKR RNRSKPLFHH FTTAIDTENI
RFVFHAVKDT ILQENLKDIM LQ
//
