ID A0A287AKN3_PIG Unreviewed; 196 AA.
AC A0A287AKN3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Calcineurin like EF-hand protein 2 {ECO:0000313|Ensembl:ENSSSCP00000044450.1};
GN Name=CHP2 {ECO:0000313|Ensembl:ENSSSCP00000044450.1,
GN ECO:0000313|VGNC:VGNC:86658};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000044450.1, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000044450.1, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000044450.1,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000044450.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the calcineurin regulatory subunit family. CHP
CC subfamily. {ECO:0000256|ARBA:ARBA00038164}.
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DR RefSeq; XP_013847634.1; XM_013992180.1.
DR AlphaFoldDB; A0A287AKN3; -.
DR SMR; A0A287AKN3; -.
DR STRING; 9823.ENSSSCP00000044450; -.
DR Ensembl; ENSSSCT00000062165.2; ENSSSCP00000044450.1; ENSSSCG00000034827.2.
DR VGNC; VGNC:86658; CHP2.
DR GeneTree; ENSGT00940000161957; -.
DR InParanoid; A0A287AKN3; -.
DR OMA; YHRFQAL; -.
DR OrthoDB; 339700at2759; -.
DR Proteomes; UP000008227; Chromosome 3.
DR Bgee; ENSSSCG00000034827; Expressed in ileum and 30 other cell types or tissues.
DR ExpressionAtlas; A0A287AKN3; baseline.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
DR GO; GO:0071277; P:cellular response to calcium ion; IEA:Ensembl.
DR GO; GO:0070886; P:positive regulation of calcineurin-NFAT signaling cascade; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0042307; P:positive regulation of protein import into nucleus; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR PANTHER; PTHR46002:SF6; CALCINEURIN B HOMOLOGOUS PROTEIN 2; 1.
DR PANTHER; PTHR46002; EG:114D9.1 PROTEIN-RELATED; 1.
DR Pfam; PF13202; EF-hand_5; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR SMART; SM00054; EFh; 3.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Myristate {ECO:0000256|ARBA:ARBA00022707};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
FT DOMAIN 111..146
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 152..187
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
SQ SEQUENCE 196 AA; 22461 MW; 646145CFB7D4EF43 CRC64;
MGSRSSHAAR IPDVDSIRRE TGFSQASLLR LYHRFQALDR NEKGYLSRMD LQQIGALAVN
PLGDRIIESF FPDGSMRVDF PGFVRVLAHF RPVDDEDEGN RDPKEPEPLN SRMNKLRFAF
QLYDLDRDGK ISRLEMLQVL RLMVGVQVTE EQLESIADRT VQEADEDGDG AVSFLEFAKS
LEKMNIEQKM SIRILK
//
