ID   A0A287AM91_PIG          Unreviewed;      1047 AA.
AC   A0A287AM91;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2022, sequence version 3.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Unc-13 homolog D {ECO:0000313|Ensembl:ENSSSCP00000045003.3};
GN   Name=UNC13D {ECO:0000313|Ensembl:ENSSSCP00000045003.3,
GN   ECO:0000313|VGNC:VGNC:94703};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000045003.3, ECO:0000313|Proteomes:UP000008227};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000045003.3, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000045003.3,
RC   ECO:0000313|Proteomes:UP000008227};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSSCP00000045003.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the unc-13 family.
CC       {ECO:0000256|ARBA:ARBA00005823}.
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DR   AlphaFoldDB; A0A287AM91; -.
DR   Ensembl; ENSSSCT00000043027.3; ENSSSCP00000045003.3; ENSSSCG00000017200.5.
DR   VGNC; VGNC:94703; UNC13D.
DR   GeneTree; ENSGT00730000110939; -.
DR   Proteomes; UP000008227; Chromosome 12.
DR   Bgee; ENSSSCG00000017200; Expressed in blood and 36 other cell types or tissues.
DR   ExpressionAtlas; A0A287AM91; baseline and differential.
DR   GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR   GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR   CDD; cd08676; C2A_Munc13-like; 1.
DR   CDD; cd04009; C2B_Munc13-like; 1.
DR   Gene3D; 1.10.357.50; -; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 2.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR010439; MUN_dom.
DR   InterPro; IPR014770; Munc13_1.
DR   InterPro; IPR014772; Munc13_dom-2.
DR   PANTHER; PTHR45999:SF3; PROTEIN UNC-13 HOMOLOG D; 1.
DR   PANTHER; PTHR45999; UNC-13-4A, ISOFORM B; 1.
DR   Pfam; PF00168; C2; 2.
DR   Pfam; PF06292; MUN; 1.
DR   SMART; SM00239; C2; 2.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR   PROSITE; PS50004; C2; 2.
DR   PROSITE; PS51258; MHD1; 1.
DR   PROSITE; PS51259; MHD2; 1.
PE   3: Inferred from homology;
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT   DOMAIN          93..240
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          558..678
FT                   /note="MHD1"
FT                   /evidence="ECO:0000259|PROSITE:PS51258"
FT   DOMAIN          746..853
FT                   /note="MHD2"
FT                   /evidence="ECO:0000259|PROSITE:PS51259"
FT   DOMAIN          868..993
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
SQ   SEQUENCE   1047 AA;  118488 MW;  E230E41DD188C084 CRC64;
     MATLFPHSQR RPPLLRQAIK IRRRRVRDLQ DPLPPRAQEV ETPSHHFSSE ERALLYEEAL
     YTVLYRLGQP EPNHVGESSE LLRYLQEAFH MEPEEHLQML QQVQELEKPV FCLKATVKQA
     KGILGKDVSG FSDPYCLLAI IEQGAAVPGG SPGPRRRQKA VVRHTIPEEQ THRTQVITQT
     LNPVWDETFI LEFGDINNAS FHLDMWDLDT VESVRQKLGE LTDLHGLRRI FKEARKDKGQ
     DDFLGNVVLR LQDLHCREDQ WYPLEPCTET YPDRGQCHLQ FQFIHKRRAT VASRSQPSYT
     VHLHLLQQLV SHEVTQHQAG STSWDGSLSA HAATILFLHA TQKDLSDFHR SLAQWLAYSR
     LYQSLEFPSS CLLYPITSIE YQWIQGRLKA EQLEELATSF NSLLAYGLSL IRRFRSVFPL
     SVSDSPARLQ SLLRVLVQMC KMKAFGELCP DSTPLPQLVT EALRTGTVEW FHLKQQHHQP
     MVQGLLEAAK ALLSLVQDIT GDLHQCQRTW NKIFHNVLKI DLFSVAFQEL QWLVAKRVQD
     HTAAMGDAVT PEIGESLFQL YVSLKDLCRL GPVPSERDGV LALDGFHRWF QPAIPSWLQK
     TYSVALARVQ RAVQMDKLVP LGELTKHSTS AVDLSTCFAQ ISHTARQLDW PDPEEAFMIT
     VKFVEDTCRL ALVYCSLIKA RARELSAGQK DQGQAANMLC VVVNNMEQLR LVKIRTGVRT
     LAEQLEVGIA KHIQKLVGIK ESVLPEDAIL PLMKFLEVEL CYMNTNLVQE NFSSLLTLLW
     THTLMVLAEV AASQRSCPLA SRRLKIALQN LEICFYAEGC GLPPEALHTA TFQALQRDLE
     LQAASSRELI QKYFCSRIQQ QAETASEELG AVTVKASYRA SEQKLRVELL SASSLLPLDS
     NGSSDPFVQL TLEPRHVFPE LAPRETQKHK KDLHPLFDET FEFLVPAEPC RKDGACLLLT
     VLDHDTLGAD DLEGEAFLPL HSVPGLTGTE EPGEVPQTRL PLTYPAPNGD PVLQLLESRK
     GDREAQGFVR LRRQRAKQAS QHPPPGR
//