ID A0A287ANN1_PIG Unreviewed; 1062 AA.
AC A0A287ANN1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=ADAMTS like 4 {ECO:0000313|Ensembl:ENSSSCP00000045620.2};
GN Name=ADAMTSL4 {ECO:0000313|Ensembl:ENSSSCP00000045620.2,
GN ECO:0000313|VGNC:VGNC:85093};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000045620.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000045620.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000045620.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000045620.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A287ANN1; -.
DR Ensembl; ENSSSCT00000037797.3; ENSSSCP00000045620.2; ENSSSCG00000006651.5.
DR VGNC; VGNC:85093; ADAMTSL4.
DR GeneTree; ENSGT00940000161136; -.
DR Proteomes; UP000008227; Chromosome 4.
DR Bgee; ENSSSCG00000006651; Expressed in endocardial endothelium and 33 other cell types or tissues.
DR ExpressionAtlas; A0A287ANN1; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005614; C:interstitial matrix; IEA:Ensembl.
DR GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR GO; GO:0002064; P:epithelial cell development; IEA:Ensembl.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:Ensembl.
DR GO; GO:0070285; P:pigment cell development; IEA:Ensembl.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR Gene3D; 2.60.120.830; -; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 6.
DR InterPro; IPR045371; ADAMTS_CR_3.
DR InterPro; IPR010294; ADAMTS_spacer1.
DR InterPro; IPR010909; PLAC.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR13723; ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE; 1.
DR PANTHER; PTHR13723:SF144; ADAMTS-LIKE PROTEIN 4; 1.
DR Pfam; PF19236; ADAMTS_CR_3; 1.
DR Pfam; PF05986; ADAMTS_spacer1; 1.
DR Pfam; PF08686; PLAC; 1.
DR Pfam; PF19030; TSP1_ADAMTS; 6.
DR Pfam; PF00090; TSP_1; 1.
DR SMART; SM00209; TSP1; 7.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 6.
DR PROSITE; PS50900; PLAC; 1.
DR PROSITE; PS50092; TSP1; 6.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1062
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023853621"
FT DOMAIN 1017..1054
FT /note="PLAC"
FT /evidence="ECO:0000259|PROSITE:PS50900"
FT REGION 74..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 998..1025
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..146
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..217
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..247
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..317
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1004..1019
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1062 AA; 115177 MW; 4A1BD99AAD6F6F2C CRC64;
MEKQAIRPGL CLMLLLSLPQ LCLDQEVLSG HSLQTPPEES QGPEGVWGPW DQWASCSQPC
GVGVQRRSRK CQLPAAHLHQ GRPPRHPEGL LPRGQGPRPQ TSRETLPLYR PPPRGRGGPF
RGPASQLGRE EARETQGARR SRVRDPIKPG MFGYGRVPFA LPLHRNRRHP RRPLRSELSQ
TTPSLMPRAV PSSANHTPQT ELPPTAPSAP ARSPPADSPS PEAAQTEVPS RTEPAPTGPH
PSTRASVTGP SSPPPPGEGR SFHASPQPRR PGSQGGASPQ LAERHPHPFL SVPPGRGQQS
PERWRPGGDR LRSLTESAPH HPHGWLPLLS TGPHSSSLWS LFAPSSPVPR CSGESEQLRA
CSQAPCPPEQ PDPRALQCAA FDSQEFMGQL YQWEPFTEVQ GSQRCELNCR PRGFRFYVRH
TEKVQDGTLC QPGALDICVA GRCLSPGCDG ILGSGRRPDG CGVCGGDDST CRLVSGNLTD
PGGSLGYQKI LVIPAGASRL HIAQLRPSSN YIALRGPGGQ SIINGNWAVD PPGSYTAGGT
VFRYNRPPRE EGAGESLSAE GPTTQPVDVY MIFQEESPGV FYQYVISSPP PDLENPTPEP
HLPQLQPEIF RVEPPPASAS RPARTPGTLQ RQVRIPQMPA PSHPRTHLGS PTGYWKRVGH
SECSASCGKG VWRPIFLCVS RESGEELDER SCAMGARPPA SQEPCHGPPC PPYWETGEWT
SCSRSCGPGT QHRQLRCRQE FGGGGSSVPP ERCGHLPRPN ITQPCQLRLC GHWEVRSPWS
QCSVRCGRGQ RSRQVRCVGN NGDEVSEQEC ASGPPRPPSR EACDMGPCTT AWFHSDWSSK
CSAECGTGIQ RRSVVCLGSG EAHGVGQEEA GAGASEQTCA PGSRPPDMRA CSLGPCEVTW
CWYTGPWAEC SSECGSGTQR RDIICVSKLG TEFNVTSPSN CSHLPRPPAL QPCQGQNCQD
RWFSTPWSPC SRSCQGGVQT REVQCLTANQ TLSTRCPPHL RPSRKRSCNS QPCSQRPDDQ
CKDSSPHCPL VVQARLCVYP YYTSTCCRSC AHVLERSPPE PA
//
